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Thiazole

General

Thiazole, or 1,3-thiazole, is a five atom heterocyclic compound that contains both sulfur and nitrogen. Building block for many inhibitors of enzymes
Inhibitor Main targeted enzyme families Type Structure
Quinolyl-methylene-hydrazono-thiazol-pyrocatechol-Cpd3i Hydrazide Quinoline Catechol Thiazole Sulfur Compound
Benzothiazol-piperidin-ethoxy-chromen-Cpd13a ACHE Piperidine Coumarin Chromen Thiazole Benzothiazol Sulfur Compound
Benzothiazol-morpholino-ethoxy-chromen-Cpd13m ACHE BCHE Morpholine Coumarin Chromen Thiazole Benzothiazol Sulfur Compound
Benzyl-phenyl-cyclopropylcarbonylamino-thiazole-carboxamide-Cpd6l Carboxamide Thiazole Cyclopropyl Sulfur Compound
Benzyloxy-phenylthiazol-ylidenehydrazonomethyl-chromenone-Cpd5b ACHE Chromen Thiazole Sulfur Compound Coumarin
N-saccharinopentyl-benzylamino-cpd8b Alkyl linked bis-ligand Sulfur Compound Thiazole Benzothiazol Derivative of Saccharin
Arylidene-hydrazinyl-1,3-thiazole-cpd8 ACHE Thiazole Sulfur Compound Hydrazinylidene Hydrazide Multitarget BACE1-inhibitor Organochlorine
Arylidene-hydrazinyl-1,3-thiazole-cpd14 ACHE Thiazole Sulfur Compound Hydrazinylidene Hydrazide Multitarget BACE1-inhibitor Organochlorine
Methoxyphenyl-thiazol-2-aminothiazole-morpholin-Cpd14s Thiazole Sulfur Compound Morpholine Isophthalamide Carboxamide
3-allylrhodanine-hydroxyethoxybenzylidene-hydroisoquinoline-Cpd11 BCHE ACHE Thiazolidine Thiazole Sulfur Compound Isoquinoline
3-allylrhodanine-hydroxymethoxybenzylidene-hydroisoquinoline-Cpd6 BCHE ACHE Thiazolidine Thiazole Sulfur Compound Isoquinoline
Compound-D1f BCHE ACHE Derivative of Donepezil Sulfur Compound Thiazole Hydrazide Cyanide Piperidine
2-Oxoindolin-thiazoline-Cpd3i ACHE BCHE Sulfur Compound Thiazole Trifluoro Multitarget PPARgamma ligand Indole
2-Oxoindolin-thiazoline-Cpd4i ACHE BCHE Thiazolidine Thiazole Sulfur Compound Trifluoro Multitarget PPARgamma ligand Indole Hydrazide
Prenylated-Arylidene-thiazolidine-Cpd22b Pancreatic_lipase Thiazolidine Thiazole Sulfur Compound
FLAP-sEH-dual-inhibitor-Cpd6 Epoxide_hydrolase Urea derivative Multitarget Thiazole Adamantyl 5-Lipoxygenase inhibitor
Diflapolin Epoxide_hydrolase Urea derivative Multitarget Thiazole Benzothiazol Sulfur Compound FLAP inhibitor Organochlorine
Morpholino-phenylthiazolidin-one-Cpd12 ACHE BCHE Thiazolidine Thiazole Sulfur Compound Morpholine Hydrazide
Pyrazoline-Thiazole-Cpd3f Pyrazole Pyrazoline Thiophen Sulfur Compound Thiazole Nitrobenzyl Dimethoxyphenyl
Pyrazoline-Thiazole-Cpd3g Pyrazole Pyrazoline Thiophen Sulfur Compound Thiazole Dimethoxyphenyl Cyanide
LB05 ACHE Piperazine Thiazole Benzothiazol Sulfur Compound Organochlorine
Triazole-tethered-benzothiazole-cpd10f ACHE Triazol Benzothiazol Sulfur Compound Multitarget Thiazole
HaloPROTAC3 Haloalkane_dehalogenase-HLD2 HaloTag-ligand PROTAC Sulfur Compound Thiazole Pyrrolidine Organochlorine
Oxoimidazolidin-trifluoromethyl-thiazole-5-carboxamide-Cpd50 Epoxide_hydrolase Imidazole Trifluoro Thiazole Carboxamide Sulfur Compound Organochlorine
Triazole-thiazolidinedione-benzothiazole-cpd7k ACHE Triazol Thiazolidine Benzothiazol Thiazole Dioxothiazolidine Sulfur Compound
Diethylamino-chromen-thiazol-acetamide ACHE Thiazole Sulfur Compound Coumarin Chromen
CHEMBL513063 ACHE Sulfur Compound Thiazole Pyrrolidine
BDBM243037 ACHE Sulfur Compound Thiazole Piperazine
Dimethoxyphenyl-pyrrolidin-butoxyphenyl-thiazol-acetamide ACHE Sulfur Compound Thiazole Pyrrolidine Dimethoxyphenyl
Dioxothiazolidin-benzothiazol-methoxyphenyl-acrylamide-Cpd49 ACHE Monoamine-oxidase-inhibitor Multitarget BACE1-inhibitor Carboxamide Acrylate Benzothiazol Thiazole Dioxothiazolidine Sulfur Compound
Benzothiazol-carboxamide-benzyl-piperazine-dimethylamine-cpd4f ACHE Monoamine-oxidase-inhibitor Multitarget Piperazine Carboxamide Benzothiazol Thiazole Sulfur Compound
HY-155961 DPP4N_Peptidase_S9 Thiazolidine Sulfur Compound Pyrazole Pyrrolidine Thiazole
Oprea1_491201 ACHE Thiazole Carbonic anhydrase inhibitor Multitarget Sulfur Compound Sulfonamide
SW-17 Epoxide_hydrolase Sulfur Compound Multitarget Thiazole Piperidine Carboxamide Organochlorine
CHEMBL4278686 ACHE GSK-3 kinase inhibitor Derivative of Tacrine Acridine Multitarget Thiazole Carboxamide Pyridine Cyclopropyl Sulfur Compound
2-Amino-6-methylbenzothiazole Epoxide_hydrolase Benzothiazol Sulfur Compound Thiazole
TI45b ACHE Trifluoro Triazol Thiazole Sulfur Compound Indazole
Naphthalen-1-yloxymethyl-triazol-thiazol-cpd35a BCHE Naphthalen Triazol Thiazole Sulfur Compound
Naphthalen-2-yloxymethyl-triazol-thiazol-cpd37a BCHE Naphthalen Triazol Thiazole Sulfur Compound
JNJ-42226314 Monoglyceridelipase_lysophospholip Indole Thiazole Sulfur Compound Azetidin Piperazine
Tosyl-Octyl-2-aminobenzo-thiazole-6-carboxylate-cpd6k BCHE ACHE Monoamine-oxidase-inhibitor Multitarget Urea derivative Benzothiazol Sulfur Compound Sulfonamide Thiazole
Thiazol-abietane-Cpd18 ABHD16 Thiazole Sulfur Compound Phenanthrene
BR102910 DPP4N_Peptidase_S9 Quinoline Carboxamide Pyrrolidine Cyanide Sulfur Compound Thiazole Organochlorine
SBP-7635 Thioesterase Thiazolidine Sulfonamide Sulfur Compound Benzenesulfonamide Thiazole
SBP-7957 Thioesterase Morpholine Thiazolidine Sulfur Compound Sulfonamide Thiazole
Fragment-690 Pectinacetylesterase-Notum Fragment inhibitor of Notum Sulfur Compound Thiazole
Riluzole Pectinacetylesterase-Notum Drug Benzothiazol Trifluoro Sulfur Compound Not AlphaBeta Hydrolase target Fragment inhibitor of Notum Thiazole
T-401 Monoglyceridelipase_lysophospholip Pyrrolidine Piperazine PET probe Pyridine Thiazole Sulfur Compound
ML114 Hydrolase_RBBP9_YdeN Thiazolidine Sulfur Compound Thiazole
CHEMBL3233608-S0J-3WKC Epoxide_hydrolase Thiazolidine Sulfur Compound Thiazole
CHEMBL3233606-S0F-3WK9 Epoxide_hydrolase Thiazolidine Sulfur Compound Thiazole
CHEMBL442384-S0E-3WK8 Epoxide_hydrolase Benzothiazol Not AlphaBeta Hydrolase target Trifluoro Sulfur Compound Thiazole
ZINC527968-S0B-3WK6 Epoxide_hydrolase Sulfur Compound Thiazole
CHEMBL3233604-S0C-3WK5 Epoxide_hydrolase Sulfur Compound Thiazole
Fragment-064-notum-screen Pectinacetylesterase-Notum Urea derivative Fragment inhibitor of Notum Sulfur Compound Thiazole
SPB01403 Monoglyceridelipase_lysophospholip Carbamate FAAH inhibitor Multitarget Sulfur Compound Thiazole
JU5 BCHE Coumarin Piperidine Carboxamide Naphthalen Sulfur Compound Thiazole Chromen
GD29 ACHE GSK-3 kinase inhibitor Multitarget Thiazole Pyridine Piperidine Cyclopropyl Carboxamide Sulfur Compound Derivative of Donepezil
GT15 ACHE Derivative of Tacrine Acridine GSK-3 kinase inhibitor Sulfur Compound Multitarget Carboxamide Pyridine Thiazole Cyclopropyl
sEH-LTA4H-14 Epoxide_hydrolase Urea derivative LTA4-hydrolase-inhibitor Multitarget Sulfur Compound Thiazole Benzothiazol