Trp2-Tat-(1-9)

DPPIV peptidase activity is inhibited by N-terminal nonapeptide Tat-(1-9) of Tat protein from human immunodeficiency virus (HIV)-1 with amino acid sequence here a mutant with Trp2 MWPVDPNIE

General

Type : Peptide, Sulfur Compound

Chemical_Nomenclature : MWPVDPNIE

Canonical SMILES : CC.CCC(C)C(C(=O)NC(CCC(=O)O)C(=O)O)NC(=O)C(CC(=O)N)NC(=O)C1CCCN1C(=O)C(CC(=O)O)NC(=O)C(C(C)C)NC(=O)C2CCCN2C(=O)C(CC3=CNC4C3CCC=C4)NC(=O)C(CCSC)N

InChI :

InChIKey :

Other name(s) : H-Met-Trp-Pro-Val-Asp-Pro-Asn-Ile-Glu-OH || MWPVDPNIE || HIV-1 Trp2 Tat(1-9) || HIV-1 Trp2 tat Protein (1-9)

MW : 1104.28

Formula : C50H77N11O15S

CAS_number :

PubChem :

UniChem :

Target

Families : Trp2-Tat-(1-9) ligand of proteins in family
DPP4N_Peptidase_S9

Structure :
2BGN

Protein :
human-DPP4

References (1)

Title : Crystal structures of HIV-1 Tat-derived nonapeptides Tat-(1-9) and Trp2-Tat-(1-9) bound to the active site of dipeptidyl-peptidase IV (CD26) - Weihofen_2005_J.Biol.Chem_280_14911

Author(s) : Weihofen WA , Liu J , Reutter W , Saenger W , Fan H

Ref : Journal of Biological Chemistry , 280 :14911 , 2005

Abstract :

PubMedSearch : Weihofen_2005_J.Biol.Chem_280_14911

PubMedID: 15695814

Gene_locus related to this paper: human-DPP4

Trp2-Tat-(1-9)

General

Target

References (1)

1. Crystal structures of HIV-1 Tat-derived nonapeptides Tat-(1-9) and Trp2-Tat-(1-9) bound to the active site of dipeptidyl-peptidase IV (CD26) - Weihofen_2005_J.Biol.Chem_280_14911