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T-82(1)

Not to be confounded with other products called also T82 phenothiazin piperazinyl trimethoxybenzoates which are like Methophenazine calmodulin inhibitors

General

Type : Piperidine,Quinoline

Chemical_Nomenclature : 2-[2-(1-benzylpiperidin-4-yl)ethyl]-9-methoxy-3H-pyrrolo[3,4-b]quinolin-1-one

Canonical SMILES : COC1=C2C(=NC3=CC=CC=C31)CN(C2=O)CCC4CCN(CC4)CC5=CC=CC=C5

InChI : InChI=1S\/C26H29N3O2\/c1-31-25-21-9-5-6-10-22(21)27-23-18-29(26(30)24(23)25)16-13-19-11-14-28(15-12-19)17-20-7-3-2-4-8-20\/h2-10,19H,11-18H2,1H3

InChIKey : UQMVECQBCVBXGA-UHFFFAOYSA-N

Other name(s) : T-82,T 82,(2-[2-(1-benzylpiperidin-4-yl)ethyl]-2,3-dihydro-9-methoxy-1H-pyrrolo [3,4-b]quinolin-1-one hemifumarate,AC1L43OW,SCHEMBL195472,2-[2-(1-benzylpiperidin-4-yl)ethyl]-9-methoxy-3H-pyrrolo[3,4-b]quinolin-1-one,2-[2-(1-Benzylpiperidine-4-yl)ethyl]-9-methoxy-2H-pyrrolo[3,4-b]quinoline-1(3H)-one,ZINC000000604745,142471-56-5,J1.696.325I,DTXSID40162050

MW : 415.53 + 58

Formula : C26H29N3O2 + 1\/2C4H4O4

CAS_number : 142471-56-5

PubChem : 178654

UniChem : UQMVECQBCVBXGA-UHFFFAOYSA-N

Target

Families : T-82(1) ligand of proteins in family
ACHE

References (2)

Title : Effects of T-82, a novel acetylcholinesterase inhibitor, on impaired learning and memory in passive avoidance task in rats - Isomae_2003_Eur.J.Pharmacol_465_97
Author(s) : Isomae K , Morimoto S , Hasegawa H , Morita K , Kamei J
Ref : European Journal of Pharmacology , 465 :97 , 2003
Abstract : Isomae_2003_Eur.J.Pharmacol_465_97
ESTHER : Isomae_2003_Eur.J.Pharmacol_465_97
PubMedSearch : Isomae_2003_Eur.J.Pharmacol_465_97
PubMedID: 12650838

Title : Effects of T-82, a new quinoline derivative, on cholinesterase activity and extracellular acetylcholine concentration in rat brain - Isoma_2002_Jpn.J.Pharmacol_88_206
Author(s) : Isoma K , Ishikawa M , Ohta M , Ogawa Y , Hasegawa H , Kohda T , Kamei J
Ref : Japanese Journal of Pharmacology , 88 :206 , 2002
Abstract : Isoma_2002_Jpn.J.Pharmacol_88_206
ESTHER : Isoma_2002_Jpn.J.Pharmacol_88_206
PubMedSearch : Isoma_2002_Jpn.J.Pharmacol_88_206
PubMedID: 11928722 
Array
(
    [id] => 4482
    [inhibitor] => T-82(1)
    [type] => Array
        (
            [0] => Piperidine
            [1] => Quinoline
        )

    [other_name] => Array
        (
            [0] => T-82
            [1] => T 82
            [2] => (2-[2-(1-benzylpiperidin-4-yl)ethyl]-2,3-dihydro-9-methoxy-1H-pyrrolo [3,4-b]quinolin-1-one hemifumarate
            [3] => AC1L43OW
            [4] => SCHEMBL195472
            [5] => 2-[2-(1-benzylpiperidin-4-yl)ethyl]-9-methoxy-3H-pyrrolo[3,4-b]quinolin-1-one
            [6] => 2-[2-(1-Benzylpiperidine-4-yl)ethyl]-9-methoxy-2H-pyrrolo[3,4-b]quinoline-1(3H)-one
            [7] => ZINC000000604745
            [8] => 142471-56-5
            [9] => J1.696.325I
            [10] => DTXSID40162050
        )

    [chemical_nomenclature] => 2-[2-(1-benzylpiperidin-4-yl)ethyl]-9-methoxy-3H-pyrrolo[3,4-b]quinolin-1-one
    [formula] => C26H29N3O2 + 1\/2C4H4O4
    [cas_number] => 142471-56-5
    [mw] => 415.53 + 58
    [pick_me_to_call] => display_script
    [kinetic_parameter] => 
    [paper] => Isoma_2002_Jpn.J.Pharmacol_88_206 || Isomae_2003_Eur.J.Pharmacol_465_97
    [comment] => Not to be confounded with other products called also T82 phenothiazin piperazinyl trimethoxybenzoates which are like Methophenazine calmodulin inhibitors
    [gene_locus] => 
    [kin_inhibitor] => 
    [cid] => 178654
    [family] => ACHE
    [inchikey] => UQMVECQBCVBXGA-UHFFFAOYSA-N
    [canonicalsmiles] => COC1=C2C(=NC3=CC=CC=C31)CN(C2=O)CCC4CCN(CC4)CC5=CC=CC=C5
    [inchi] => InChI=1S\/C26H29N3O2\/c1-31-25-21-9-5-6-10-22(21)27-23-18-29(26(30)24(23)25)16-13-19-11-14-28(15-12-19)17-20-7-3-2-4-8-20\/h2-10,19H,11-18H2,1H3
    [wikipedia] => 
    [iupharlig] => 
    [structure] => 
    [substrate] => 
    [interact_gene_locus] => 
    [mutation] => 
    [comment2] => 
    [extoxnet] => 
    [news] => 
    [theoretical_model] => 
)