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Imipramine

Imipramine is the prototypical tricyclic antidepressant. It has been used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. It has less sedative effect than some other members of this therapeutic group.

General

Type : Adrenergic Uptake Inhibitors,Not A\/B H target,Drug,Azepine,Benzazepin

Chemical_Nomenclature : 10,11-Dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5propanamine

Canonical SMILES : CN(C)CCCN1C2=CC=CC=C2CCC3=CC=CC=C31

InChI : InChI=1S\/C19H24N2\/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21\/h3-6,8-11H,7,12-15H2,1-2H3

InChIKey : BCGWQEUPMDMJNV-UHFFFAOYSA-N

Other name(s) : Imidobenzyle,Antideprin,Dimipressin,Melipramin,Melipramine,Nelipramin,Berkomine,Impramine,Intalpram,imizin

MW : 280.407

Formula : C19H24N2

CAS_number : 50-49-7

PubChem : 3696

UniChem : BCGWQEUPMDMJNV-UHFFFAOYSA-N

Wikipedia : Imipramine

Target

Families : Imipramine ligand of proteins in family
BCHE

References (4)

Title : Parasympatholytic activity of psychoactive drugs in rat brain mitochondria - Nag_1995_Ind.J.Exp.Biol_33_462
Author(s) : Nag M , Basu PS , Nandi N
Ref : Indian Journal of Experimental Biology , 33 :462 , 1995
Abstract : Nag_1995_Ind.J.Exp.Biol_33_462
ESTHER : Nag_1995_Ind.J.Exp.Biol_33_462
PubMedSearch : Nag_1995_Ind.J.Exp.Biol_33_462
PubMedID: 7590953

Title : Neurochemical and histopathologic alterations characteristic of Pick's disease in a non-demented individual - Sparks_1994_J.Neuropathol.Exp.Neurol_53_37
Author(s) : Sparks DL , Danner FW , Davis DG , Hackney C , Landers T , Coyne CM
Ref : Journal of Neuropathology & Experimental Neurology , 53 :37 , 1994
Abstract : Sparks_1994_J.Neuropathol.Exp.Neurol_53_37
ESTHER : Sparks_1994_J.Neuropathol.Exp.Neurol_53_37
PubMedSearch : Sparks_1994_J.Neuropathol.Exp.Neurol_53_37
PubMedID: 8301318

Title : A peptidase activity exhibited by human serum pseudocholinesterase - Boopathy_1987_Eur.J.Biochem_162_191
Author(s) : Boopathy R , Balasubramanian AS
Ref : European Journal of Biochemistry , 162 :191 , 1987
Abstract : Boopathy_1987_Eur.J.Biochem_162_191
ESTHER : Boopathy_1987_Eur.J.Biochem_162_191
PubMedSearch : Boopathy_1987_Eur.J.Biochem_162_191
PubMedID: 3545820

Title : Chemical modification of the bifunctional human serum pseudocholinesterase. Effect on the pseudocholinesterase and aryl acylamidase activities - Boopathy_1985_Eur.J.Biochem_151_351
Author(s) : Boopathy R , Balasubramanian AS
Ref : European Journal of Biochemistry , 151 :351 , 1985
Abstract : Boopathy_1985_Eur.J.Biochem_151_351
ESTHER : Boopathy_1985_Eur.J.Biochem_151_351
PubMedSearch : Boopathy_1985_Eur.J.Biochem_151_351
PubMedID: 2863142 
Array
(
    [id] => 5223
    [inhibitor] => Imipramine
    [type] => Array
        (
            [0] => Adrenergic Uptake Inhibitors
            [1] => Not A\/B H target
            [2] => Drug
            [3] => Azepine
            [4] => Benzazepin
        )

    [other_name] => Array
        (
            [0] => Imidobenzyle
            [1] => Antideprin
            [2] => Dimipressin
            [3] => Melipramin
            [4] => Melipramine
            [5] => Nelipramin
            [6] => Berkomine
            [7] => Impramine
            [8] => Intalpram
            [9] => imizin
        )

    [chemical_nomenclature] => 10,11-Dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5propanamine
    [formula] => C19H24N2
    [cas_number] => 50-49-7
    [mw] => 280.407
    [pick_me_to_call] => display_script
    [kinetic_parameter] => 
    [paper] => Nag_1995_Ind.J.Exp.Biol_33_462 || Sparks_1994_J.Neuropathol.Exp.Neurol_53_37 || Boopathy_1985_Eur.J.Biochem_151_351 || Boopathy_1987_Eur.J.Biochem_162_191
    [comment] => Imipramine is the prototypical tricyclic antidepressant. It has been used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. It has less sedative effect than some other members of this therapeutic group.
    [gene_locus] => 
    [kin_inhibitor] => 
    [cid] => 3696
    [family] => BCHE
    [inchikey] => BCGWQEUPMDMJNV-UHFFFAOYSA-N
    [canonicalsmiles] => CN(C)CCCN1C2=CC=CC=C2CCC3=CC=CC=C31
    [inchi] => InChI=1S\/C19H24N2\/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21\/h3-6,8-11H,7,12-15H2,1-2H3
    [wikipedia] => Imipramine
    [iupharlig] => 
    [structure] => 
    [substrate] => 
    [interact_gene_locus] => 
    [mutation] => 
    [comment2] => 
    [extoxnet] => 
    [news] => 
    [theoretical_model] => 
)