Salicylic-acid
Salicylic Acid (SA) is a natural beta hydroxy acid in plants (bark of the white willow and wintergreen leaves).SA is a critical signal for the activation of plant defense responses against pathogen infections. SA can be methylated or conjugated to glucose. SABP2 binds SA with high affinity (Kd of 90 nM). SABP2 has strong esterase activity with methyl salicylate. SA has direct activity as an anti-inflammatory agent and acts as a topical antibacterial agent due to its ability to promote exfoliation.
General
Type : Natural,Salicylic
Chemical_Nomenclature : 2-hydroxybenzoic acid
Canonical SMILES : C1=CC=C(C(=C1)C(=O)O)O
InChI : InChI=1S\/C7H6O3\/c8-6-4-2-1-3-5(6)7(9)10\/h1-4,8H,(H,9,10)
InChIKey : YGSDEFSMJLZEOE-UHFFFAOYSA-N
Other name(s) : Salicylic acid,2-Hydroxybenzoic acid,O-hydroxybenzoic acid,Salonil,O-Carboxyphenol
MW : 138.12
Formula : C7H6O3
CAS_number : 69-72-7
PubChem : 338
UniChem : YGSDEFSMJLZEOE-UHFFFAOYSA-N
IUPHAR :
Wikipedia : Salicylic_acid
Target
Families : Salicylic-acid ligand of proteins in family: Hydroxynitrile_lyase
Stucture : 1Y7I Salicylic Acid-Binding Protein 2 (Sabp2) From Nicotiana Tabacum, A Methylsalicylate Esterase, complex with 2-Hydroxybenzoic acid
Protein : nicta-SABP2
References (1)
| Title : Structural and biochemical studies identify tobacco SABP2 as a methyl salicylate esterase and implicate it in plant innate immunity - Forouhar_2005_Proc.Natl.Acad.Sci.U.S.A_102_1773 |
| Author(s) : Forouhar F , Yang Y , Kumar D , Chen Y , Fridman E , Park SW , Chiang Y , Acton TB , Montelione GT , Pichersky E , Klessig DF , Tong L |
| Ref : Proc Natl Acad Sci U S A , 102 :1773 , 2005 |
| Abstract : Forouhar_2005_Proc.Natl.Acad.Sci.U.S.A_102_1773 |
| ESTHER : Forouhar_2005_Proc.Natl.Acad.Sci.U.S.A_102_1773 |
| PubMedSearch : Forouhar_2005_Proc.Natl.Acad.Sci.U.S.A_102_1773 |
| PubMedID: 15668381 |
| Gene_locus related to this paper: nicta-SABP2 |