spiro-b-lactam-pyrroloquinoline-6b
IC50 0.81 +/- 0.04 micoM
General
Type : Azaspiro,beta-Lactam,Pyrrolidine,Quinoline
Chemical_Nomenclature :
Canonical SMILES : C1(=CC=C2C(=C1)C=C3C(=N2)N(C(C34CC(N4CC5=CC=CC=C5)=O)=O)C6CCCCC6)Cl
InChI : InChI=1S\/C26H24ClN3O2\/c27-19-11-12-22-18(13-19)14-21-24(28-22)30(20-9-5-2-6-10-20)25(32)26(21)15-23(31)29(26)16-17-7-3-1-4-8-17\/h1,3-4,7-8,11-14,20H,2,5-6,9-10,15-16H2
InChIKey : HYQVZAGHMGKNFX-UHFFFAOYSA-N
Other name(s) :
MW : 445.94
Formula : C26H24ClN3O2
CAS_number :
PubChem :
UniChem : HYQVZAGHMGKNFX-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
Families : spiro-b-lactam-pyrroloquinoline-6b ligand of proteins in family: S9N_PPCE_Peptidase_S9
Stucture :
Protein : pig-ppce
References (1)
| Title : Substrate-like novel inhibitors of prolyl specific oligo peptidase for neurodegenerative disorders - Khan_2023_J.Biomol.Struct.Dyn__1 |
| Author(s) : Khan M , Halim SA , Waqas M , Golmohammadi F , Balalaie S , Csuk R , Uddin J , Khan A , Al-Harrasi A |
| Ref : J Biomol Struct Dyn , :1 , 2023 |
| Abstract : Khan_2023_J.Biomol.Struct.Dyn__1 |
| ESTHER : Khan_2023_J.Biomol.Struct.Dyn__1 |
| PubMedSearch : Khan_2023_J.Biomol.Struct.Dyn__1 |
| PubMedID: 37608559 |
| Gene_locus related to this paper: pig-ppce |