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Inhibitor Report for: tacrine-isatin-Cpd7k

IC50 values of 0.42nM


General
Type anti-Abeta-aggregation, Derivative of Tacrine, Multitarget, Alkyl linked bis-ligand, Indole
Chemical_Nomenclature 3-((3-chlorophenyl)imino)-1-(6-((1,2,3,4-tetrahydroacridin-9-yl)amino)hexyl)indolin-2-one
Canonical SMILES C3CCC2=NC1=[C][C]=[C][C]=C1C(=C2C3)[N]CCCCCCN5C4=[C][C]=[C][C]=C4C(C5=O)=NC6=[C][C]=[C]C(=[C]6)Cl
InChI InChI=1S/C33H33ClN4O/c34-23-12-11-13-24(22-23)36-32-27-16-5-8-19-30(27)38(33(32)39)21-10-2-1-9-20-35-31-25-14-3-6-17-28(25)37-29-18-7-4-15-26(29)31/h3,5-6,8,11-14,16-17,19,22H,1-2,4,7,9-10,15,18,20-21H2,(H,35,37)
InChIKey HJOYCIDPPBFLLR-UHFFFAOYSA-N
Other name(s)
________________________________________________________________________________________________
MW|537.10
Formula|C33H33ClN4O
CAS_number|
PubChem|
UniChem|HJOYCIDPPBFLLR-UHFFFAOYSA-N
IUPHAR|
Wikipedia|

Target
Families | tacrine-isatin-Cpd7k ligand of proteins in family: ACHE
Protein | human-ACHE

References:
Search PubMed for references concerning: tacrine-isatin-Cpd7k
    Title: Design, synthesis and biological activity of novel tacrine-isatin Schiff base hybrid derivatives
    Riazimontazer E, Sadeghpour H, Nadri H, Sakhteman A, Tuylu Kucukkilinc T, Miri R, Edraki N
    Ref: Bioorg Chem, 89:103006, 2019 : PubMed