D131N_human-ACHE

General

Gene Locus : human-ACHE

Mode of mutation : Site directed mutagenesis

Disease :

Summary : Back door hypothesis External charge at the rim of the hypothetical back door,No effect of mutation Shafferman_1992_4th.ChE.Meeting.Eilat__165 Kronman_1994_J.Biol.Chem_269_27819

AAA Change :

Allelic Variant :

Risk Factor :

Inhibitor :

Structure :

Disease by interaction :

Interact Gene Locus :

Xenobiotic sensitivity :

Modification : Back door hypothesis

Torpedo_number : 128

Kinetic Parameter : 3,3-dimethylbutylthioacetate_D131N_human-ACHE, Acetylthiocholine_D131N_human-ACHE, Edrophonium_D131N_human-ACHE

News : No news

Comment :
p.D131N Asp131Asn (p.D152N Asp152Asn in primary sequence with 31 amino-acids signal peptide) Back door hypothesis\;External charge at the rim of the hypothetical back door,No effect of mutation

References (2)

Title : The back door hypothesis for product clearance in acetylcholinesterase challenged by site-directed mutagenesis - Kronman_1994_J.Biol.Chem_269_27819
Author(s) : Kronman C , Ordentlich A , Barak D , Velan B , Shafferman A
Ref : Journal of Biological Chemistry , 269 :27819 , 1994
Abstract :
PubMedSearch : Kronman_1994_J.Biol.Chem_269_27819
PubMedID: 7961709

Title : Acetylcholinesterase Catalysis - Protein Engineering Studies -
Author(s) : Shafferman A , Velan B
Ref : In Multidisciplinary approaches to cholinesterase functions - Proceedings of Fourth International Meeting on Cholinesterases , (Shafferman, A. and Velan, B., Eds) Plenum Press, New York :165 , 1992
PubMedID: