Gene Locus : human-ACHE
Mode of mutation : Site directed mutagenesis
Disease :
Summary : Electrostatic Electrostatic attraction hypothesis, minor effect on catalysis Shafferman_1994_EMBO.J_13_3448
AAA Change :
Allelic Variant :
Risk Factor :
Inhibitor :
Structure :
Disease by interaction :
Interact Gene Locus :
Xenobiotic sensitivity :
Modification : Electrostatic
Torpedo_number : 383
Kinetic Parameter : Acetylthiocholine_D390N_human-ACHE, 3,3-dimethylbutylthioacetate_D390N_human-ACHE, Edrophonium_D390N_human-ACHE
News : No news
Comment :
p.D390N Asp390Asn (p.D421N Asp421Asn in primary sequence with 31 amino-acids signal peptide) Electrostatic attraction hypothesis, minor effect on catalysis
| Title : Electrostatic attraction by surface charge does not contribute to the catalytic efficiency of acetylcholinesterase - Shafferman_1994_EMBO.J_13_3448 |
| Author(s) : Shafferman A , Ordentlich A , Barak D , Kronman C , Ber R , Bino T , Ariel N , Osman R , Velan B |
| Ref : EMBO Journal , 13 :3448 , 1994 |
| Abstract : |
| PubMedSearch : Shafferman_1994_EMBO.J_13_3448 |
| PubMedID: 8062821 |