Gene Locus : human-ACHE
Mode of mutation : Site directed mutagenesis
Disease :
Summary : Peripheral Anionic Site Peripheral Anionic Site\/signal transduction\/allosteric modulation\/substrate inhibition. Affects conformation of active site and PAS Shafferman_1992_EMBO.J_11_3561 Shafferman_1992_4th.ChE.Meeting.Eilat__165 || Signal transduction Affects conformation of active site and PAS Shafferman_1992_EMBO.J_11_3561 Shafferman_1992_4th.ChE.Meeting.Eilat__165
AAA Change :
Allelic Variant :
Risk Factor :
Inhibitor :
Structure :
Disease by interaction :
Interact Gene Locus :
Xenobiotic sensitivity :
Modification : Peripheral Anionic Site || Substrate inhibition || Signal transduction || Allosteric modulation
Torpedo_number : 72
Kinetic Parameter : BW284C51_D74K_human-ACHE, Decamethonium_D74K_human-ACHE, Propidium_D74K_human-ACHE, Edrophonium_D74K_human-ACHE, Acetylthiocholine_D74K_human-ACHE
News : No news
Comment :
p.D74K Asp74Lys (p.D105K Asp105Lys in primary sequence with 31 amino-acids signal peptide) Peripheral Anionic Site\/signal transduction\/allosteric modulation\/substrate inhibition. Affects conformation of active site and PAS\;
| Title : Substrate inhibition of acetylcholinesterase: residues affecting signal transduction from the surface to the catalytic center - Shafferman_1992_EMBO.J_11_3561 |
| Author(s) : Shafferman A , Velan B , Ordentlich A , Kronman C , Grosfeld H , Leitner M , Flashner Y , Cohen S , Barak D , Ariel N |
| Ref : EMBO Journal , 11 :3561 , 1992 |
| Abstract : |
| PubMedSearch : Shafferman_1992_EMBO.J_11_3561 |
| PubMedID: 1396557 |
| Title : Acetylcholinesterase Catalysis - Protein Engineering Studies - |
| Author(s) : Shafferman A , Velan B |
| Ref : In Multidisciplinary approaches to cholinesterase functions - Proceedings of Fourth International Meeting on Cholinesterases , (Shafferman, A. and Velan, B., Eds) Plenum Press, New York :165 , 1992 |
| PubMedID: |