E197C_human-BCHE

General

Gene Locus : human-BCHE

Mode of mutation : Site directed mutagenesis

Disease :

Summary : OP-resistance Zhang_2012_J.Pharmacol.Exp.Ther_343_673

AAA Change :

Allelic Variant :

Risk Factor :

Inhibitor :

Structure :

Disease by interaction :

Interact Gene Locus :

Xenobiotic sensitivity :

Modification : OP-resistance

Torpedo_number : 199

Kinetic Parameter : No kinetic parameter

News : No news

Comment :
p.E197C Glu197Cys (p.E225C Glu225Cys in primary sequence with 28 amino-acids signal peptide) OP-resistance

References (1)

Title : Identification of Human Butyrylcholinesterase Organophosphate-Resistant Variants through a Novel Mammalian Enzyme Functional Screen - Zhang_2012_J.Pharmacol.Exp.Ther_343_673
Author(s) : Zhang J , Chen S , Ralph EC , Dwyer MA , Cashman JR
Ref : Journal of Pharmacology & Experimental Therapeutics , 343 :673 , 2012
PubMedID: 22956723