E358Q_human-ACHE

General

Gene Locus : human-ACHE

Mode of mutation : Site directed mutagenesis

Disease :

Summary : Electrostatic Electrostatic attraction hypothesis, minor effect on catalysis Shafferman_1994_EMBO.J_13_3448

AAA Change :

Allelic Variant :

Risk Factor :

Inhibitor :

Structure :

Disease by interaction :

Interact Gene Locus :

Xenobiotic sensitivity :

Modification : Electrostatic

Torpedo_number : 351

Kinetic Parameter : Acetylthiocholine_E358Q_human-ACHE, 3,3-dimethylbutylthioacetate_E358Q_human-ACHE, Edrophonium_E358Q_human-ACHE

News : No news

Comment :
p.E358Q Glu358Gln (p.E389Q Glu389Gln in primary sequence with 31 amino-acids signal peptide) Electrostatic attraction hypothesis, minor effect on catalysis

References (1)

Title : Electrostatic attraction by surface charge does not contribute to the catalytic efficiency of acetylcholinesterase - Shafferman_1994_EMBO.J_13_3448
Author(s) : Shafferman A , Ordentlich A , Barak D , Kronman C , Ber R , Bino T , Ariel N , Osman R , Velan B
Ref : EMBO Journal , 13 :3448 , 1994
PubMedID: 8062821