N464Q_human-ACHE

General

Gene Locus : human-ACHE

Mode of mutation : Site directed mutagenesis

Disease :

Summary : N-glycosylation yield of secretion 20-30\% Velan_1992_4th.ChE.Meeting.Eilat__39 Velan_1993_Biochem.J_296_649

AAA Change :

Allelic Variant :

Risk Factor :

Inhibitor :

Structure :

Disease by interaction :

Interact Gene Locus :

Xenobiotic sensitivity :

Modification : N-glycosylation

Torpedo_number : 457

Kinetic Parameter : No kinetic parameter

News : No news

Comment :
p.N464Q Asn464Gln (p.N495Q Asn495Gln in primary sequence with 31 amino-acids signal peptide) N-glycosylation\;yield of secretion 20-30\%

References (2)

Title : N-glycosylation of human acetylcholinesterase: effects on activity, stability and biosynthesis - Velan_1993_Biochem.J_296_649
Author(s) : Velan B , Kronman C , Ordentlich A , Flashner Y , Leitner M , Cohen S , Shafferman A
Ref : Biochemical Journal , 296 :649 , 1993
PubMedID: 8280063

Title : Molecular Organization of Recombinant Human Acetylcholinesterase -
Author(s) : Velan B , Kronman C , Leitner M
Ref : In Multidisciplinary approaches to cholinesterase functions - Proceedings of Fourth International Meeting on Cholinesterases , (Shafferman, A. and Velan, B., Eds) Plenum Press, New York :39 , 1992
PubMedID: