Gene Locus : human-EPHX2
Mode of mutation : Natural mutant
Disease :
Summary :
AAA Change :
Allelic Variant :
Risk Factor : Hypercholesterolemia, familial due to LDLR defect, modifier of
Inhibitor :
Structure :
Disease by interaction :
Interact Gene Locus :
Xenobiotic sensitivity :
Modification :
Torpedo_number : No torpedo number
Kinetic Parameter : No kinetic parameter
News : No news
Comment :
p.R287Q Arg287Gln
| Title : Role of sEH R287Q in LDLR expression, LDL binding to LDLR and LDL internalization in BEL-7402 cells - Tang_2018_Gene_667_95 |
| Author(s) : Tang L , Wang G , Jiang L , Chen P , Wang W , Chen J , Wang L |
| Ref : Gene , 667 :95 , 2018 |
| Abstract : |
| PubMedSearch : Tang_2018_Gene_667_95 |
| PubMedID: 29665449 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Arg287Gln variant of EPHX2 and epoxyeicosatrienoic acids are associated with insulin sensitivity in humans - Ramirez_2014_Prostaglandins.Other.Lipid.Mediat_113-115_38 |
| Author(s) : Ramirez CE , Shuey MM , Milne GL , Gilbert K , Hui N , Yu C , Luther JM , Brown NJ |
| Ref : Prostaglandins Other Lipid Mediat , 113-115 :38 , 2014 |
| Abstract : |
| PubMedSearch : Ramirez_2014_Prostaglandins.Other.Lipid.Mediat_113-115_38 |
| PubMedID: 25173047 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Soluble epoxide hydrolase dimerization is required for hydrolase activity - Nelson_2013_J.Biol.Chem_288_7697 |
| Author(s) : Nelson JW , Subrahmanyan RM , Summers SA , Xiao X , Alkayed NJ |
| Ref : Journal of Biological Chemistry , 288 :7697 , 2013 |
| Abstract : |
| PubMedSearch : Nelson_2013_J.Biol.Chem_288_7697 |
| PubMedID: 23362272 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Polymorphisms in the human soluble epoxide hydrolase gene EPHX2 linked to neuronal survival after ischemic injury - Koerner_2007_J.Neurosci_27_4642 |
| Author(s) : Koerner IP , Jacks R , DeBarber AE , Koop D , Mao P , Grant DF , Alkayed NJ |
| Ref : Journal of Neuroscience , 27 :4642 , 2007 |
| Abstract : |
| PubMedSearch : Koerner_2007_J.Neurosci_27_4642 |
| PubMedID: 17460077 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Soluble epoxide hydrolase variant (Glu287Arg) modifies plasma total cholesterol and triglyceride phenotype in familial hypercholesterolemia: intrafamilial association study in an eight-generation hyperlipidemic kindred - Sato_2004_J.Hum.Genet_49_29 |
| Author(s) : Sato K , Emi M , Ezura Y , Fujita Y , Takada D , Ishigami T , Umemura S , Xin Y , Wu LL , Larrinaga-Shum S , Stephenson SH , Hunt SC , Hopkins PN |
| Ref : J Hum Genet , 49 :29 , 2004 |
| Abstract : |
| PubMedSearch : Sato_2004_J.Hum.Genet_49_29 |
| PubMedID: 14673705 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Polymorphisms in human soluble epoxide hydrolase - Przybyla-Zawislak_2003_Mol.Pharmacol_64_482 |
| Author(s) : Przybyla-Zawislak BD , Srivastava PK , Vazquez-Matias J , Mohrenweiser HW , Maxwell JE , Hammock BD , Bradbury JA , Enayetallah AE , Zeldin DC , Grant DF |
| Ref : Molecular Pharmacology , 64 :482 , 2003 |
| Abstract : |
| PubMedSearch : Przybyla-Zawislak_2003_Mol.Pharmacol_64_482 |
| PubMedID: 12869654 |
| Gene_locus related to this paper: human-EPHX2 |