V127D_human-BCHE

General

Gene Locus : human-BCHE

Mode of mutation : Site directed mutagenesis

Disease :

Summary : Back door hypothesis No changes in Km BTCh or Ki of inhibitors tested Loewenstein-Lichtenstein_1996_Mol.Pharmacol_50_1423

AAA Change :

Allelic Variant :

Risk Factor :

Inhibitor :

Structure :

Disease by interaction :

Interact Gene Locus :

Xenobiotic sensitivity :

Modification : Back door hypothesis

Torpedo_number : 129

Kinetic Parameter : Butyrylthiocholine_V127D_human-BCHE, Tacrine_V127D_human-BCHE, Succinylcholine~Suxamethonium_V127D_human-BCHE, Dibucaine_V127D_human-BCHE, Solanine_V127D_human-BCHE, BW284C51_V127D_human-BCHE

News : No news

Comment :
p.V127D Val127Asp (p.V155D Val155Asp in primary sequence with 28 amino-acids signal peptide) Back door hypothesis\; No changes in Km BTCh or Ki of inhibitors tested

References (1)

Title : Overlapping drug interaction sites of human butyrylcholinesterase dissected by site-directed mutagenesis - Loewenstein-Lichtenstein_1996_Mol.Pharmacol_50_1423
Author(s) : Loewenstein-Lichtenstein Y , Glick D , Gluzman N , Sternfeld M , Zakut H , Soreq H
Ref : Molecular Pharmacology , 50 :1423 , 1996
Abstract :
PubMedSearch : Loewenstein-Lichtenstein_1996_Mol.Pharmacol_50_1423
PubMedID: 8967962
Gene_locus related to this paper: human-BCHE