Gene Locus : human-ACHE
Mode of mutation : Site directed mutagenesis
Disease :
Summary : Back door hypothesis V132K introduce a charge and should block the door, 6X increase of Km for ATc but not for TB through interaction with W86 Kronman_1994_J.Biol.Chem_269_27819
AAA Change :
Allelic Variant :
Risk Factor :
Inhibitor :
Structure :
Disease by interaction :
Interact Gene Locus :
Xenobiotic sensitivity :
Modification : Back door hypothesis
Torpedo_number : 129
Kinetic Parameter : 3,3-dimethylbutylthioacetate_V132K_human-ACHE, Acetylthiocholine_V132K_human-ACHE, Edrophonium_V132K_human-ACHE
News : No news
Comment :
p.V132K Val132Lys (p.V163K Val163Lys in primary sequence with 31 amino-acids signal peptide) Back door hypothesis\;V132K introduce a charge and should block the door, 6X increase of Km for ATc but not for TB through interaction with W86
| Title : The back door hypothesis for product clearance in acetylcholinesterase challenged by site-directed mutagenesis - Kronman_1994_J.Biol.Chem_269_27819 |
| Author(s) : Kronman C , Ordentlich A , Barak D , Velan B , Shafferman A |
| Ref : Journal of Biological Chemistry , 269 :27819 , 1994 |
| Abstract : |
| PubMedSearch : Kronman_1994_J.Biol.Chem_269_27819 |
| PubMedID: 7961709 |