V132K_human-ACHE

General

Gene Locus : human-ACHE

Mode of mutation : Site directed mutagenesis

Disease :

Summary : Back door hypothesis V132K introduce a charge and should block the door, 6X increase of Km for ATc but not for TB through interaction with W86 Kronman_1994_J.Biol.Chem_269_27819

AAA Change :

Allelic Variant :

Risk Factor :

Inhibitor :

Structure :

Disease by interaction :

Interact Gene Locus :

Xenobiotic sensitivity :

Modification : Back door hypothesis

Torpedo_number : 129

Kinetic Parameter : 3,3-dimethylbutylthioacetate_V132K_human-ACHE, Acetylthiocholine_V132K_human-ACHE, Edrophonium_V132K_human-ACHE

News : No news

Comment :
p.V132K Val132Lys (p.V163K Val163Lys in primary sequence with 31 amino-acids signal peptide) Back door hypothesis\;V132K introduce a charge and should block the door, 6X increase of Km for ATc but not for TB through interaction with W86

References (1)

Title : The back door hypothesis for product clearance in acetylcholinesterase challenged by site-directed mutagenesis - Kronman_1994_J.Biol.Chem_269_27819
Author(s) : Kronman C , Ordentlich A , Barak D , Velan B , Shafferman A
Ref : Journal of Biological Chemistry , 269 :27819 , 1994
PubMedID: 7961709