Y332S_human-BCHE

General

Gene Locus : human-BCHE

Mode of mutation : Site directed mutagenesis

Disease :

Summary : OP-resistance increased resistance to nerve agent retained robust intrinsic catalytic efficiency Dwyer_2014_Biochemistry_53_4476

AAA Change :

Allelic Variant :

Risk Factor :

Inhibitor :

Structure :

Disease by interaction :

Interact Gene Locus :

Xenobiotic sensitivity :

Modification : OP-resistance

Torpedo_number : 334

Kinetic Parameter : No kinetic parameter

News : JUNE-11-2014

Comment :
p.Y332S Tyr332Ser (p.Y360S Tyr360Ser in primary sequence with 28 amino-acids signal peptide) OP-resistance\;increased resistance to nerve agent retained robust intrinsic catalytic efficiency

References (1)

Title : Novel human butyrylcholinesterase variants: toward organophosphonate detoxication - Dwyer_2014_Biochemistry_53_4476
Author(s) : Dwyer M , Javor S , Ryan DA , Smith EM , Wang B , Zhang J , Cashman JR
Ref : Biochemistry , 53 :4476 , 2014
PubMedID: 24902043