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Mutation Report for: Y440D_human-BCHE

Y440D_human-BCHE
Gene_Locus|human-BCHE
Mode of mutation|Site directed mutagenesis
Amino Acid change|Y440D
Torpedo number|442
Summary|
Comment|p.Y440D Tyr440Asp (p.Y468D Tyr468Asp in primary sequence with 28 amino-acids signal peptide) OP-resistance; increases Km towards BChE and IC50 for iso-OMPA
Kinetic parameters|Butyrylthiocholine_Y440D_human-BCHE,
DFP_Y440D_human-BCHE,
Echothiophate_Y440D_human-BCHE,
Iso-OMPA_Y440D_human-BCHE


References:
    Title: Site-directed mutagenesis of active site residues reveals plasticity of human butyrylcholinesterase in substrate and inhibitor interactions
    Gnatt A, Loewenstein Y, Yaron A, Schwarz M, Soreq H
    Ref: Journal of Neurochemistry, 62:749, 1994 : PubMed

            




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Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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