| Title : Administration of amyloid beta-peptides into the medial septum of rats decreases acetylcholine release from hippocampus in vivo - Abe_1994_Brain.Res_636_162 |
| Author(s) : Abe E , Casamenti F , Giovannelli L , Scali C , Pepeu G |
| Ref : Brain Research , 636 :162 , 1994 |
|
Abstract :
The septum of male Wistar rats was injected with synthetic beta-amyloid fragments, beta 12-28, beta 25-35 and beta 1-40, and hippocampal acetylcholine (ACh) release was evaluated by transversal microdialysis. A marked decrease in basal and K(+)-evoked ACh release was found 7 or 21 days after injection of 5 nmol of beta 12-28 and beta 25-35, or 3 nmol of beta 1-40, respectively. These data indicate that septal injection of beta-amyloid peptides causes hypofunction of the septo-hippocampal cholinergic system. |
| PubMedSearch : Abe_1994_Brain.Res_636_162 |
| PubMedID: 8156403 |
Abe E, Casamenti F, Giovannelli L, Scali C, Pepeu G (1994)
Administration of amyloid beta-peptides into the medial septum of rats decreases acetylcholine release from hippocampus in vivo
Brain Research
636 :162
Abe E, Casamenti F, Giovannelli L, Scali C, Pepeu G (1994)
Brain Research
636 :162