| Title : N-[5-(5-fluoropyridin-3-yl)-1H-pyrazol-3-yl]-4-piperidin-1-ylbutyramide (SEN78702, WYE-308775): a medicinal chemistry effort toward an alpha7 nicotinic acetylcholine receptor agonist preclinical candidate - Zanaletti_2012_J.Med.Chem_55_10277 |
| Author(s) : Zanaletti R , Bettinetti L , Castaldo C , Ceccarelli I , Cocconcelli G , Comery TA , Dunlop J , Genesio E , Ghiron C , Haydar SN , Jow F , Maccari L , Micco I , Nencini A , Pratelli C , Scali C , Turlizzi E , Valacchi M |
| Ref : Journal of Medicinal Chemistry , 55 :10277 , 2012 |
| Abstract : |
| PubMedSearch : Zanaletti_2012_J.Med.Chem_55_10277 |
| PubMedID: 23083093 |
| Title : Discovery of a novel alpha-7 nicotinic acetylcholine receptor agonist series and characterization of the potent, selective, and orally efficacious agonist 5-(4-acetyl[1,4]diazepan-1-yl)pentanoic acid [5-(4-methoxyphenyl)-1H-pyrazol-3-yl] amide (SEN15924, WAY-361789) - Zanaletti_2012_J.Med.Chem_55_4806 |
| Author(s) : Zanaletti R , Bettinetti L , Castaldo C , Cocconcelli G , Comery T , Dunlop J , Gaviraghi G , Ghiron C , Haydar SN , Jow F , Maccari L , Micco I , Nencini A , Scali C , Turlizzi E , Valacchi M |
| Ref : Journal of Medicinal Chemistry , 55 :4806 , 2012 |
| Abstract : |
| PubMedSearch : Zanaletti_2012_J.Med.Chem_55_4806 |
| PubMedID: 22468936 |
| Title : Preclinical assessment of an adjunctive treatment approach for cognitive impairment associated with schizophrenia using the alpha7 nicotinic acetylcholine receptor agonist WYE-103914\/SEN34625 - Marquis_2011_Psychopharmacology.(Berl)_218_635 |
| Author(s) : Marquis KL , Comery TA , Jow F , Navarra RL , Grauer SM , Pulicicchio C , Kelley C , Brennan JA , Roncarati R , Scali C , Haydar S , Ghiron C , Terstappen GC , Dunlop J |
| Ref : Psychopharmacology (Berl) , 218 :635 , 2011 |
| Abstract : |
| PubMedSearch : Marquis_2011_Psychopharmacology.(Berl)_218_635 |
| PubMedID: 21643676 |
| Title : Novel alpha-7 nicotinic acetylcholine receptor agonists containing a urea moiety: identification and characterization of the potent, selective, and orally efficacious agonist 1-[6-(4-fluorophenyl)pyridin-3-yl]-3-(4-piperidin-1-ylbutyl) urea (SEN34625\/WYE-103914) - Ghiron_2010_J.Med.Chem_53_4379 |
| Author(s) : Ghiron C , Haydar SN , Aschmies S , Bothmann H , Castaldo C , Cocconcelli G , Comery TA , Di L , Dunlop J , Lock T , Kramer A , Kowal D , Jow F , Grauer S , Harrison B , La Rosa S , Maccari L , Marquis KL , Micco I , Nencini A , Quinn J , Robichaud AJ , Roncarati R , Scali C , Terstappen GC , Turlizzi E , Valacchi M , Varrone M , Zanaletti R , Zanelli U |
| Ref : Journal of Medicinal Chemistry , 53 :4379 , 2010 |
| Abstract : |
| PubMedSearch : Ghiron_2010_J.Med.Chem_53_4379 |
| PubMedID: 20465311 |
| Title : SAR and biological evaluation of SEN12333\/WAY-317538: Novel alpha 7 nicotinic acetylcholine receptor agonist - Haydar_2009_Bioorg.Med.Chem_17_5247 |
| Author(s) : Haydar SN , Ghiron C , Bettinetti L , Bothmann H , Comery TA , Dunlop J , La Rosa S , Micco I , Pollastrini M , Quinn J , Roncarati R , Scali C , Valacchi M , Varrone M , Zanaletti R |
| Ref : Bioorganic & Medicinal Chemistry , 17 :5247 , 2009 |
| Abstract : |
| PubMedSearch : Haydar_2009_Bioorg.Med.Chem_17_5247 |
| PubMedID: 19515567 |
| Title : Poster: In vitro pharmacological characterization and pro-cognitive effects of the selective alpha-7 nicotinic agonist WYE-103914 - |
| Author(s) : Dunlop J , Comery TA , Lock T , Kramer A , Kowal D , Yeola S , Jow F , Aschmies S , Lin Q , Beyer CE , Brennan J , Kelley C , Roncarati R , Scali C , Haydar S , Ghiron C , Marquis KL , Harrison B , Robichaud A , Terstappen GC |
| Ref : Biochemical Pharmacology , 78 :911 , 2009 |
| PubMedID: |
| Title : Procognitive and neuroprotective activity of a novel alpha7 nicotinic acetylcholine receptor agonist for treatment of neurodegenerative and cognitive disorders - Roncarati_2009_J.Pharmacol.Exp.Ther_329_459 |
| Author(s) : Roncarati R , Scali C , Comery TA , Grauer SM , Aschmi S , Bothmann H , Jow B , Kowal D , Gianfriddo M , Kelley C , Zanelli U , Ghiron C , Haydar S , Dunlop J , Terstappen GC |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 329 :459 , 2009 |
| Abstract : |
| PubMedSearch : Roncarati_2009_J.Pharmacol.Exp.Ther_329_459 |
| PubMedID: 19223665 |
| Title : Poster: Characterization of the alpha-7 nicotinic receptor agonist WYE-103914 in models relevant to schizophrenia and interaction with antipsychotics - |
| Author(s) : Marquis KL , Comery TA , Navarra RL , Leiser S , Grauer SM , Pulicicchio C , Kelley C , Roncarati R , Scali C , Haydar S , Ghiron C , Harrison B , Robichaud A , Terstappen GC , Dunlop J |
| Ref : Biochemical Pharmacology , 78 :911 , 2009 |
| PubMedID: |
| Title : Cholinergic dysfunction, neuronal damage and axonal loss in TgCRND8 mice - Bellucci_2006_Neurobiol.Dis_23_260 |
| Author(s) : Bellucci A , Luccarini I , Scali C , Prosperi C , Giovannini MG , Pepeu G , Casamenti F |
| Ref : Neurobiol Dis , 23 :260 , 2006 |
| Abstract : |
| PubMedSearch : Bellucci_2006_Neurobiol.Dis_23_260 |
| PubMedID: 16766197 |
| Title : Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer beta-amyloid peptide in rodent - Greig_2005_Proc.Natl.Acad.Sci.U.S.A_102_17213 |
| Author(s) : Greig NH , Utsuki T , Ingram DK , Wang Y , Pepeu G , Scali C , Yu QS , Mamczarz J , Holloway HW , Giordano T , Chen D , Furukawa K , Sambamurti K , Brossi A , Lahiri DK |
| Ref : Proc Natl Acad Sci U S A , 102 :17213 , 2005 |
| Abstract : |
| PubMedSearch : Greig_2005_Proc.Natl.Acad.Sci.U.S.A_102_17213 |
| PubMedID: 16275899 |
| Title : The selective cyclooxygenase-2 inhibitor rofecoxib suppresses brain inflammation and protects cholinergic neurons from excitotoxic degeneration in vivo - Scali_2003_Neurosci_117_909 |
| Author(s) : Scali C , Giovannini MG , Prosperi C , Bellucci A , Pepeu G , Casamenti F |
| Ref : Neuroscience , 117 :909 , 2003 |
| Abstract : |
| PubMedSearch : Scali_2003_Neurosci_117_909 |
| PubMedID: 12654342 |
| Title : Beta-amyloid-induced inflammation and cholinergic hypofunction in the rat brain in vivo: involvement of the p38MAPK pathway - Giovannini_2002_Neurobiol.Dis_11_257 |
| Author(s) : Giovannini MG , Scali C , Prosperi C , Bellucci A , Vannucchi MG , Rosi S , Pepeu G , Casamenti F |
| Ref : Neurobiol Dis , 11 :257 , 2002 |
| Abstract : |
| PubMedSearch : Giovannini_2002_Neurobiol.Dis_11_257 |
| PubMedID: 12505419 |
| Title : Rivastigmine antagonizes deficits in prepulse inhibition induced by selective immunolesioning of cholinergic neurons in nucleus basalis magnocellularis - Ballmaier_2002_Neurosci_114_91 |
| Author(s) : Ballmaier M , Casamenti F , Scali C , Mazzoncini R , Zoli M , Pepeu G , Spano PF |
| Ref : Neuroscience , 114 :91 , 2002 |
| Abstract : |
| PubMedSearch : Ballmaier_2002_Neurosci_114_91 |
| PubMedID: 12207957 |
| Title : Effect of subchronic administration of metrifonate, rivastigmine and donepezil on brain acetylcholine in aged F344 rats - Scali_2002_J.Neural.Transm_109_1067 |
| Author(s) : Scali C , Casamenti F , Bellucci A , Costagli C , Schmidt B , Pepeu G |
| Ref : J Neural Transm , 109 :1067 , 2002 |
| Abstract : |
| PubMedSearch : Scali_2002_J.Neural.Transm_109_1067 |
| PubMedID: 12111444 |
| Title : Brain inflammatory reaction in an animal model of neuronal degeneration and its modulation by an anti-inflammatory drug: implication in Alzheimer's disease - Scali_2000_Eur.J.Neurosci_12_1900 |
| Author(s) : Scali C , Prosperi C , Vannucchi MG , Pepeu G , Casamenti F |
| Ref : European Journal of Neuroscience , 12 :1900 , 2000 |
| Abstract : |
| PubMedSearch : Scali_2000_Eur.J.Neurosci_12_1900 |
| PubMedID: 10886331 |
| Title : Interleukin-1beta activates forebrain glial cells and increases nitric oxide production and cortical glutamate and GABA release in vivo: implications for Alzheimer's disease - Casamenti_1999_Neurosci_91_831 |
| Author(s) : Casamenti F , Prosperi C , Scali C , Giovannelli L , Colivicchi MA , Faussone-Pellegrini MS , Pepeu G |
| Ref : Neuroscience , 91 :831 , 1999 |
| Abstract : |
| PubMedSearch : Casamenti_1999_Neurosci_91_831 |
| PubMedID: 10391466 |
| Title : Effects of novelty and pain on behavior and hippocampal extracellular ACh levels in male and female rats - Ceccarelli_1999_Brain.Res_815_169 |
| Author(s) : Ceccarelli I , Casamenti F , Massafra C , Pepeu G , Scali C , Aloisi AM |
| Ref : Brain Research , 815 :169 , 1999 |
| Abstract : |
| PubMedSearch : Ceccarelli_1999_Brain.Res_815_169 |
| PubMedID: 9878722 |
| Title : Long-term changes in the aggregation state and toxic effects of beta-amyloid injected into the rat brain - Giovannelli_1998_Neurosci_87_349 |
| Author(s) : Giovannelli L , Scali C , Faussone-Pellegrini MS , Pepeu G , Casamenti F |
| Ref : Neuroscience , 87 :349 , 1998 |
| Abstract : |
| PubMedSearch : Giovannelli_1998_Neurosci_87_349 |
| PubMedID: 9740397 |
| Title : Effect of subchronic treatment with metrifonate and tacrine on brain cholinergic function in aged F344 rats - Giovannini_1998_Eur.J.Pharmacol_354_17 |
| Author(s) : Giovannini MG , Scali C , Bartolini L , Schmidt B , Pepeu G |
| Ref : European Journal of Pharmacology , 354 :17 , 1998 |
| Abstract : |
| PubMedSearch : Giovannini_1998_Eur.J.Pharmacol_354_17 |
| PubMedID: 9726626 |
| Title : Tacrine administration enhances extracellular acetylcholine in vivo and restores the cognitive impairment in aged rats - Scali_1997_Pharmacol.Res_36_463 |
| Author(s) : Scali C , Giovannini MG , Prosperi C , Bartolini L , Pepeu G |
| Ref : Pharmacol Res , 36 :463 , 1997 |
| Abstract : |
| PubMedSearch : Scali_1997_Pharmacol.Res_36_463 |
| PubMedID: 9446713 |
| Title : Effect of metrifonate on extracellular brain acetylcholine and object recognition in aged rats - Scali_1997_Eur.J.Pharmacol_325_173 |
| Author(s) : Scali C , Giovannini MG , Bartolini L , Prosperi C , Hinz V , Schmidt B , Pepeu G |
| Ref : European Journal of Pharmacology , 325 :173 , 1997 |
| Abstract : |
| PubMedSearch : Scali_1997_Eur.J.Pharmacol_325_173 |
| PubMedID: 9163564 |
| Title : Effects of novelty, pain and stress on hippocampal extracellular acetylcholine levels in male rats - Aloisi_1997_Brain.Res_748_219 |
| Author(s) : Aloisi AM , Casamenti F , Scali C , Pepeu G , Carli G |
| Ref : Brain Research , 748 :219 , 1997 |
| Abstract : |
| PubMedSearch : Aloisi_1997_Brain.Res_748_219 |
| PubMedID: 9067465 |
| Title : Selective muscarinic antagonists differentially affect in vivo acetylcholine release and memory performances of young and aged rats - Vannucchi_1997_Neurosci_79_837 |
| Author(s) : Vannucchi MG , Scali C , Kopf SR , Pepeu G , Casamenti F |
| Ref : Neuroscience , 79 :837 , 1997 |
| Abstract : |
| PubMedSearch : Vannucchi_1997_Neurosci_79_837 |
| PubMedID: 9219946 |
| Title : Amyloid beta-peptides injection into the cholinergic nuclei: morphological, neurochemical and behavioral effects - |
| Author(s) : Pepeu G , Giovannelli L , Casamenti F , Scali C , Bartolini L |
| Ref : Prog Brain Res , 109 :273 , 1996 |
| PubMedID: 9009716 |
| Title : Differential effects of amyloid peptides beta-(1-40) and beta-(25-35) injections into the rat nucleus basalis - Giovannelli_1995_Neurosci_66_781 |
| Author(s) : Giovannelli L , Casamenti F , Scali C , Bartolini L , Pepeu G |
| Ref : Neuroscience , 66 :781 , 1995 |
| Abstract : |
| PubMedSearch : Giovannelli_1995_Neurosci_66_781 |
| PubMedID: 7651609 |
| Title : Peripherally injected scopolamine differentially modulates acetylcholine release in vivo in the young and aged rats - Scali_1995_Neurosci.Lett_197_171 |
| Author(s) : Scali C , Vannucchi MG , Pepeu G , Casamenti F |
| Ref : Neuroscience Letters , 197 :171 , 1995 |
| Abstract : |
| PubMedSearch : Scali_1995_Neurosci.Lett_197_171 |
| PubMedID: 8552291 |
| Title : Nerve growth factor increases extracellular acetylcholine levels in the parietal cortex and hippocampus of aged rats and restores object recognition - Scali_1994_Neurosci.Lett_170_117 |
| Author(s) : Scali C , Casamenti F , Pazzagli M , Bartolini L , Pepeu G |
| Ref : Neuroscience Letters , 170 :117 , 1994 |
| Abstract : |
| PubMedSearch : Scali_1994_Neurosci.Lett_170_117 |
| PubMedID: 8041485 |
| Title : Administration of amyloid beta-peptides into the medial septum of rats decreases acetylcholine release from hippocampus in vivo - Abe_1994_Brain.Res_636_162 |
| Author(s) : Abe E , Casamenti F , Giovannelli L , Scali C , Pepeu G |
| Ref : Brain Research , 636 :162 , 1994 |
| Abstract : |
| PubMedSearch : Abe_1994_Brain.Res_636_162 |
| PubMedID: 8156403 |
| Title : The brain cholinergic system in ageing mammals - Pepeu_1993_J.Reprod.Fertil.Suppl_46_155 |
| Author(s) : Pepeu G , Casamenti F , Pepeu IM , Scali C |
| Ref : J Reprod Fertil Suppl , 46 :155 , 1993 |
| Abstract : |
| PubMedSearch : Pepeu_1993_J.Reprod.Fertil.Suppl_46_155 |
| PubMedID: 8315616 |
| Title : Long-term ethanol consumption by rats: effect on acetylcholine release in vivo, choline acetyltransferase activity, and behavior - Casamenti_1993_Neurosci_56_465 |
| Author(s) : Casamenti F , Scali C , Vannucchi MG , Bartolini L , Pepeu G |
| Ref : Neuroscience , 56 :465 , 1993 |
| Abstract : |
| PubMedSearch : Casamenti_1993_Neurosci_56_465 |
| PubMedID: 8247273 |
| Title : Aging of brain cholinergic neurons: pharmacological interventions - |
| Author(s) : Pepeu G , Casamenti F , Scali C , Jeglinski W |
| Ref : Clinical Neuropharmacology , 15 Suppl 1 Pt A :31A , 1992 |
| PubMedID: 1498852 |
| Title : Phosphatidylserine reverses the age-dependent decrease in cortical acetylcholine release: a microdialysis study - Casamenti_1991_Eur.J.Pharmacol_194_11 |
| Author(s) : Casamenti F , Scali C , Pepeu G |
| Ref : European Journal of Pharmacology , 194 :11 , 1991 |
| Abstract : |
| PubMedSearch : Casamenti_1991_Eur.J.Pharmacol_194_11 |
| PubMedID: 2060587 |