| Title : In vitro reactivation of sarin inhibited electric eel acetylcholinesterase by bis-pyridinium oximes bearing methoxy ether linkages - Acharya_2008_Toxicol.In.Vitro_22_525 |
| Author(s) : Acharya J , Gupta AK , Mazumder A , Dubey DK |
| Ref : Toxicol In Vitro , 22 :525 , 2008 |
|
Abstract :
Bis-pyridinium oximes connected by methoxy alkane ether linker were synthesized and their in vitro reactivation efficacy was evaluated for sarin inhibited AChE. Reactivation efficacy of synthesized compounds was compared with 2-PAM and obidoxime. Among the synthesized compounds, 1,2-dimethoxy ethylene bis-[3,3'-(hydroxyiminomethyl) pyridinium] dichloride (3P-2) and 1,3-dimethoxy propylene bis-[3,3'-(hydroxyiminomethyl) pyridinium] dichloride (3P-3) were found to be most potent reactivators for AChE inhibited by nerve agent sarin. 3P-2 and 3P-3, respectively exhibited 80% and 69% regeneration of inhibited AChE, whereas 2-PAM (well known antidote for nerve agent poisoning) showed 42% regeneration. |
| PubMedSearch : Acharya_2008_Toxicol.In.Vitro_22_525 |
| PubMedID: 18061396 |
Acharya J, Gupta AK, Mazumder A, Dubey DK (2008)
In vitro reactivation of sarin inhibited electric eel acetylcholinesterase by bis-pyridinium oximes bearing methoxy ether linkages
Toxicol In Vitro
22 :525
Acharya J, Gupta AK, Mazumder A, Dubey DK (2008)
Toxicol In Vitro
22 :525