| Title : In-vitro regeneration of sarin inhibited electric eel acetylcholinesterase by bis-pyridinium oximes bearing xylene linker - Acharya_2009_Eur.J.Med.Chem_44_1326 |
| Author(s) : Acharya J , Gupta AK , Mazumder A , Dubey DK |
| Ref : Eur Journal of Medicinal Chemistry , 44 :1326 , 2009 |
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Abstract :
A series of bis-pyridinium oximes connected by xylene linker were synthesized and their in-vitro reactivation potential was evaluated against acetylcholinesterase (AChE) inhibited by nerve agent, sarin. Among the synthesized compounds, alpha,alpha'xylene-bis-[3,3'-(hydroxyiminomethyl) pyridinium] dibromide (3b) was found to be most potent reactivator for AChE inhibited by sarin. The oxime 3b exhibits 34% regeneration of inhibited AChE, in comparison to 20 and 15% regeneration by 2-PAM and obidoxime, respectively, at a concentration of 10(-4) M within 10 min. |
| PubMedSearch : Acharya_2009_Eur.J.Med.Chem_44_1326 |
| PubMedID: 18396355 |
Acharya J, Gupta AK, Mazumder A, Dubey DK (2009)
In-vitro regeneration of sarin inhibited electric eel acetylcholinesterase by bis-pyridinium oximes bearing xylene linker
Eur Journal of Medicinal Chemistry
44 :1326
Acharya J, Gupta AK, Mazumder A, Dubey DK (2009)
Eur Journal of Medicinal Chemistry
44 :1326