Adedara_2023_J.Biochem.Mol.Toxicol_37_e23332

Reference

Title : Ellagic acid mitigates rotenone-induced damage via modulating mitochondria function in Drosophila melanogaster - Adedara_2023_J.Biochem.Mol.Toxicol_37_e23332
Author(s) : Adedara AO , Otenaike TA , Farodoye OM , Abolaji AO
Ref : J Biochem Mol Toxicol , 37 :e23332 , 2023
Abstract :

Constant, systematic exposure to rotenone has been utilized in animal models to induce Parkinsonism. Ellagic acid is a polyphenol with anti-inflammatory and antioxidative properties which is found in numerous natural fruits. Here, we investigated the therapeutic effects of ellagic acid in rotenone-induced toxicity in Drosophila melanogaster evaluating their antioxidant and mitoprotective properties. Adult flies were treated with rotenone and ellagic acid through their diet for 7 days, thereafter markers of neurotoxicity (acetylcholinesterase, monoamine oxidase, tyrosine hydroxylase), antioxidant and oxidative stress markers (hydrogen peroxide, nitric oxide, lipid peroxidation, protein carbonyl contents, catalase, total thiol, and nonprotein thiol) was measured. Mitochondrial respiration was also evaluated in the flies. Survival assay was carried out with both genders of the flies, and we observed a significant increase in the survival rate of flies exposed to both rotenone and ellagic acid when compared with the increased mortality rate in the groups exposed to rotenone alone. The impaired locomotion, altered redox status, and enzymes of neurotoxicity induced by rotenone were significantly ameliorated by ellagic acid to levels comparable to the control. In addition, rotenone-induced complex 1 inhibition and altered bioenergetic state were restored upon ellagic acid supplementation. These findings show the beneficial properties of ellagic acid against pesticides induced toxicity.

PubMedSearch : Adedara_2023_J.Biochem.Mol.Toxicol_37_e23332
PubMedID: 37294177

Related information

Citations formats

Adedara AO, Otenaike TA, Farodoye OM, Abolaji AO (2023)
Ellagic acid mitigates rotenone-induced damage via modulating mitochondria function in Drosophila melanogaster
J Biochem Mol Toxicol 37 :e23332

Adedara AO, Otenaike TA, Farodoye OM, Abolaji AO (2023)
J Biochem Mol Toxicol 37 :e23332