Title : Polymorphisms in dipeptidyl peptidase IV gene are associated with the risk of myocardial infarction in patients with atherosclerosis - Aghili_2012_Neuropeptides_46_367 |
Author(s) : Aghili N , Devaney JM , Alderman LO , Zukowska Z , Epstein SE , Burnett MS |
Ref : Neuropeptides , 46 :367 , 2012 |
Abstract :
BACKGROUND: Dipeptidyl peptidase IV (DPP-IV) is not only important in pancreatic beta-cell regulation but also has proinflammatory actions that can contribute to atherosclerosis progression. Previously, we showed that DPP-IV is co-localized with CD31 (an endothelial cell marker) in the neovessels within the human atherosclerotic plaques. These characteristics of DPP-IV may predispose patients with coronary artery disease (CAD) to plaque rupture and thus to myocardial infarction. The goal of this investigation was to determine whether genetic alterations in DPP-IV predispose to plaque vulnerability and myocardial infarction (MI). |
PubMedSearch : Aghili_2012_Neuropeptides_46_367 |
PubMedID: 23122333 |
Aghili N, Devaney JM, Alderman LO, Zukowska Z, Epstein SE, Burnett MS (2012)
Polymorphisms in dipeptidyl peptidase IV gene are associated with the risk of myocardial infarction in patients with atherosclerosis
Neuropeptides
46 :367
Aghili N, Devaney JM, Alderman LO, Zukowska Z, Epstein SE, Burnett MS (2012)
Neuropeptides
46 :367