Epstein SE

References (8)

Title : Draft Genome Sequence for Ralstonia sp. Strain OR214, a Bacterium with Potential for Bioremediation - Utturkar_2013_Genome.Announc_1_e00321
Author(s) : Utturkar SM , Bollmann A , Brzoska RM , Klingeman DM , Epstein SE , Palumbo AV , Brown SD
Ref : Genome Announc , 1 :e00321 , 2013
Abstract : Ralstonia sp. strain OR214 belongs to the class Betaproteobacteria and was isolated from subsurface sediments in Oak Ridge, TN. A member of this genus has been described as a potential bioremediation agent. Strain OR214 is tolerant to various heavy metals, such as uranium, nickel, cobalt, and cadmium. We present its draft genome sequence here.
ESTHER : Utturkar_2013_Genome.Announc_1_e00321
PubMedSearch : Utturkar_2013_Genome.Announc_1_e00321
PubMedID: 23792748
Gene_locus related to this paper: 9rals-e2t199 , ralpi-r0e2r5 , ralpi-r0e3r3 , ralpi-a0a080w8m5

Title : Draft Genome Sequence for Caulobacter sp. Strain OR37, a Bacterium Tolerant to Heavy Metals - Utturkar_2013_Genome.Announc_1_E00322
Author(s) : Utturkar SM , Bollmann A , Brzoska RM , Klingeman DM , Epstein SE , Palumbo AV , Brown SD
Ref : Genome Announc , 1 :E00322 , 2013
Abstract : Caulobacter sp. strain OR37 belongs to the class Alphaproteobacteria and was isolated from subsurface sediments in Oak Ridge, TN. Strain OR37 is noteworthy due to its tolerance to high concentrations of heavy metals, such as uranium, nickel, cobalt, and cadmium, and we present its draft genome sequence here.
ESTHER : Utturkar_2013_Genome.Announc_1_E00322
PubMedSearch : Utturkar_2013_Genome.Announc_1_E00322
PubMedID: 23792749
Gene_locus related to this paper: cauce-r0d4h5 , cauce-r0czs8 , cauce-r0egx0 , cauce-r0ekv3 , cauce-r0el45 , cauce-r0d077 , cauce-r0d5n4 , cauce-r0d5h3 , cauvi-r0ell8

Title : Polymorphisms in dipeptidyl peptidase IV gene are associated with the risk of myocardial infarction in patients with atherosclerosis - Aghili_2012_Neuropeptides_46_367
Author(s) : Aghili N , Devaney JM , Alderman LO , Zukowska Z , Epstein SE , Burnett MS
Ref : Neuropeptides , 46 :367 , 2012
Abstract : BACKGROUND: Dipeptidyl peptidase IV (DPP-IV) is not only important in pancreatic beta-cell regulation but also has proinflammatory actions that can contribute to atherosclerosis progression. Previously, we showed that DPP-IV is co-localized with CD31 (an endothelial cell marker) in the neovessels within the human atherosclerotic plaques. These characteristics of DPP-IV may predispose patients with coronary artery disease (CAD) to plaque rupture and thus to myocardial infarction. The goal of this investigation was to determine whether genetic alterations in DPP-IV predispose to plaque vulnerability and myocardial infarction (MI).
METHODS: Between Aug 2004, and March 2007, blood samples of patients (age <60) with angiographically documented CAD were collected. Demographic, clinical, risk factor, and angiographic data were recorded. Eight hundred and seventy five patients of European ancestry with angiographic CAD were divided into those with MI (n=421) and those without (n=454). A genome-wide association study was performed using the Affymetrix 6.0 chip to identify loci that predispose to MI. In the current study we only focused on DPP4 gene to assess the association of single nucleotide polymorphisms (SNPs) in the DPP-IV gene and risk of MI in patients with CAD. For genotyped SNPs, association was tested by logistic regression with significance level of 0.05. Plasma DPP-IV level was measured using a commercial ELISA kit.
RESULTS: Average patients' age at diagnosis of CAD was 46.8years for MI group and 50.8 in the non MI group. There was no difference in distribution of traditional risk factors between the two groups. We identified one SNP (rs3788979) that was significantly related to angiographic CAD with MI, vs. without MI (OR: 1.36, p=0.03). The association of the identified SNP to MI risk was not attenuated after adjustment for traditional risk factors. The SNP was associated with lower levels of plasma DPP-IV (p=0.005). Moreover, CAD patients with the major alleles (GG) and no MI had highest plasma DPP-IV levels. (481.6, p=0.002).
CONCLUSIONS: A polymorphism in the DPP-IV gene in patients with known CAD may increase the risk of MI. This SNP is associated with decreased plasma DPP4 level in patients with MI.
ESTHER : Aghili_2012_Neuropeptides_46_367
PubMedSearch : Aghili_2012_Neuropeptides_46_367
PubMedID: 23122333

Title : A genome-wide association study identifies LIPA as a susceptibility gene for coronary artery disease - Wild_2011_Circ.Cardiovasc.Genet_4_403
Author(s) : Wild PS , Zeller T , Schillert A , Szymczak S , Sinning CR , Deiseroth A , Schnabel RB , Lubos E , Keller T , Eleftheriadis MS , Bickel C , Rupprecht HJ , Wilde S , Rossmann H , Diemert P , Cupples LA , Perret C , Erdmann J , Stark K , Kleber ME , Epstein SE , Voight BF , Kuulasmaa K , Li M , Schafer AS , Klopp N , Braund PS , Sager HB , Demissie S , Proust C , Konig IR , Wichmann HE , Reinhard W , Hoffmann MM , Virtamo J , Burnett MS , Siscovick D , Wiklund PG , Qu L , El Mokthari NE , Thompson JR , Peters A , Smith AV , Yon E , Baumert J , Hengstenberg C , Marz W , Amouyel P , Devaney J , Schwartz SM , Saarela O , Mehta NN , Rubin D , Silander K , Hall AS , Ferrieres J , Harris TB , Melander O , Kee F , Hakonarson H , Schrezenmeir J , Gudnason V , Elosua R , Arveiler D , Evans A , Rader DJ , Illig T , Schreiber S , Bis JC , Altshuler D , Kavousi M , Witteman JC , Uitterlinden AG , Hofman A , Folsom AR , Barbalic M , Boerwinkle E , Kathiresan S , Reilly MP , O'Donnell CJ , Samani NJ , Schunkert H , Cambien F , Lackner KJ , Tiret L , Salomaa V , Munzel T , Ziegler A , Blankenberg S
Ref : Circ Cardiovasc Genet , 4 :403 , 2011
Abstract : BACKGROUND: eQTL analyses are important to improve the understanding of genetic association results. We performed a genome-wide association and global gene expression study to identify functionally relevant variants affecting the risk of coronary artery disease (CAD). METHODS AND RESULTS: In a genome-wide association analysis of 2078 CAD cases and 2953 control subjects, we identified 950 single-nucleotide polymorphisms (SNPs) that were associated with CAD at P<10(-3). Subsequent in silico and wet-laboratory replication stages and a final meta-analysis of 21 428 CAD cases and 38 361 control subjects revealed a novel association signal at chromosome 10q23.31 within the LIPA (lysosomal acid lipase A) gene (P=3.7x10(-8); odds ratio, 1.1; 95% confidence interval, 1.07 to 1.14). The association of this locus with global gene expression was assessed by genome-wide expression analyses in the monocyte transcriptome of 1494 individuals. The results showed a strong association of this locus with expression of the LIPA transcript (P=1.3x10(-96)). An assessment of LIPA SNPs and transcript with cardiovascular phenotypes revealed an association of LIPA transcript levels with impaired endothelial function (P=4.4x10(-3)). CONCLUSIONS: The use of data on genetic variants and the addition of data on global monocytic gene expression led to the identification of the novel functional CAD susceptibility locus LIPA, located on chromosome 10q23.31. The respective eSNPs associated with CAD strongly affect LIPA gene expression level, which was related to endothelial dysfunction, a precursor of CAD.
ESTHER : Wild_2011_Circ.Cardiovasc.Genet_4_403
PubMedSearch : Wild_2011_Circ.Cardiovasc.Genet_4_403
PubMedID: 21606135
Gene_locus related to this paper: human-LIPA

Title : Electrical stability of acutely ischemic myocardium. Influences of heart rate and vagal stimulation -
Author(s) : Kent KM , Smith ER , Redwood DR , Epstein SE
Ref : Circulation , 47 :291 , 1973
PubMedID: 4684930

Title : Influence of atropine and of vagally mediated bradycardia on the occurrence of ventricular arrhythmias following acute coronary occlusion in closed-chest dogs -
Author(s) : Goldstein RE , Karsh RB , Smith ER , Orlando M , Norman D , Farnham G , Redwood DR , Epstein SE
Ref : Circulation , 47 :1180 , 1973
PubMedID: 4709536

Title : Coronary artery occlusion in the conscious dog. Effects of alterations in heart rate and arterial pressure on the degree of myocardial ischemia -
Author(s) : Redwood DR , Smith ER , Epstein SE
Ref : Circulation , 46 :323 , 1972
PubMedID: 5046026

Title : Atropine and acute myocardial infarction -
Author(s) : Epstein SE , Redwood DR , Smith ER
Ref : Circulation , 45 :1273 , 1972
PubMedID: 5032824