Albers_2004_J.Occup.Environ.Med_46_367

Reference

Title : The effects of occupational exposure to chlorpyrifos on the neurologic examination of central nervous system function: a prospective cohort study - Albers_2004_J.Occup.Environ.Med_46_367
Author(s) : Albers JW , Berent S , Garabrant DH , Giordani B , Schweitzer SJ , Garrison RP , Richardson RJ
Ref : J Occup Environ Med , 46 :367 , 2004
Abstract :

Questions persist about adverse effects such as impaired cognition and attention, incoordination, spasticity, or parkinsonism from chronic, low-level exposures to organophosphate (OP) compounds. In a prospective cohort study, we evaluated chlorpyrifos-manufacturing workers and a referent group on 2 occasions, 1 year apart, to determine whether occupational exposure to chlorpyrifos produced clinically evident central nervous system (CNS) dysfunction. Chlorpyrifos subjects had significantly higher TCP excretion and lower average BuChE activity than referents in a range in which physiological effects on B-esterases exist. Few subjects had neurologic symptoms or signs, and there were no significant group differences in terms of signs at baseline or second examinations. Chronic chlorpyrifos exposure produced no clinical evidence of cortical, pyramidal tract, extrapyramidal, or other CNS dysfunction among chlorpyrifos subjects compared with referents, either at baseline or after 1 year of additional chlorpyrifos exposure.

PubMedSearch : Albers_2004_J.Occup.Environ.Med_46_367
PubMedID: 15076655

Related information

Citations formats

Albers JW, Berent S, Garabrant DH, Giordani B, Schweitzer SJ, Garrison RP, Richardson RJ (2004)
The effects of occupational exposure to chlorpyrifos on the neurologic examination of central nervous system function: a prospective cohort study
J Occup Environ Med 46 :367

Albers JW, Berent S, Garabrant DH, Giordani B, Schweitzer SJ, Garrison RP, Richardson RJ (2004)
J Occup Environ Med 46 :367