Albuquerque_1986_FEBS.Lett_199_113

Reference

Title : A possible involvement of cyclic AMP in the expression of desensitization of the nicotinic acetylcholine receptor. A study with forskolin and its analogs - Albuquerque_1986_FEBS.Lett_199_113
Author(s) : Albuquerque EX , Deshpande SS , Aracava Y , Alkondon M , Daly JW
Ref : FEBS Letters , 199 :113 , 1986
Abstract :

Forskolin, an activator of adenylate cyclase, and its analogs were studied on the nicotinic acetylcholine receptor-ion channel complex (AChR) of rat and frog skeletal muscles. At nanomolar concentrations, forskolin caused desensitization of the AChR located at the junctional region of innervated and the extrajunctional region of chronically denervated rat soleus muscles. The desensitization of the AChR occurred without alteration of the conducting state (channel lifetime, conductance or bursting) as shown by single channel currents. Accordingly, forskolin decreased the peak amplitude of the repetitive evoked endplate currents in frog sartorius muscles. These findings taken together with the good correlation found between the effects of forskolin and its analogs on the desensitization of the nicotinic AChR and their ability to activate adenylate cyclase suggested a possible involvement of phosphorylation of AChR via cyclic AMP on the desensitization process.

PubMedSearch : Albuquerque_1986_FEBS.Lett_199_113
PubMedID: 2420646

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Citations formats

Albuquerque EX, Deshpande SS, Aracava Y, Alkondon M, Daly JW (1986)
A possible involvement of cyclic AMP in the expression of desensitization of the nicotinic acetylcholine receptor. A study with forskolin and its analogs
FEBS Letters 199 :113

Albuquerque EX, Deshpande SS, Aracava Y, Alkondon M, Daly JW (1986)
FEBS Letters 199 :113