Title : (R,S)-trihexyphenidyl, acting via a muscarinic receptor-independent mechanism, inhibits hippocampal glutamatergic and GABAergic synaptic transmissions: Potential relevance for treatment of organophosphorus intoxication - Aracava_2023_Neuropharmacol__109684 |
Author(s) : Aracava Y , Albuquerque EX , Pereira EFR |
Ref : Neuropharmacology , :109684 , 2023 |
Abstract : |
PubMedSearch : Aracava_2023_Neuropharmacol__109684 |
PubMedID: 37549771 |
Title : Gestational exposures to organophosphorus insecticides: From acute poisoning to developmental neurotoxicity - Todd_2020_Neuropharmacol__108271 |
Author(s) : Todd SW , Lumsden EW , Aracava Y , Mamczarz J , Albuquerque EX , Pereira EFR |
Ref : Neuropharmacology , :108271 , 2020 |
Abstract : |
PubMedSearch : Todd_2020_Neuropharmacol__108271 |
PubMedID: 32814088 |
Title : Oral Pretreatment with Galantamine Effectively Mitigates the Acute Toxicity of a Supralethal Dose of Soman in Cynomolgus Monkeys Posttreated with Conventional Antidotes - Lane_2020_J.Pharmacol.Exp.Ther_375_115 |
Author(s) : Lane M , Carter D , Pescrille JD , Aracava Y , Fawcett WP , Basinger GW , Pereira EFR , Albuquerque EX |
Ref : Journal of Pharmacology & Experimental Therapeutics , 375 :115 , 2020 |
Abstract : |
PubMedSearch : Lane_2020_J.Pharmacol.Exp.Ther_375_115 |
PubMedID: 32759369 |
Title : Animal models that best reproduce the clinical manifestations of human intoxication with organophosphorus compounds - Pereira_2014_J.Pharmacol.Exp.Ther_350_313 |
Author(s) : Pereira EF , Aracava Y , DeTolla LJ, Jr. , Beecham EJ , Basinger GW, Jr. , Wakayama EJ , Albuquerque EX |
Ref : Journal of Pharmacology & Experimental Therapeutics , 350 :313 , 2014 |
Abstract : |
PubMedSearch : Pereira_2014_J.Pharmacol.Exp.Ther_350_313 |
PubMedID: 24907067 |
Title : Galantamine prevents long-lasting suppression of excitatory synaptic transmission in CA1 pyramidal neurons of soman-challenged guinea pigs - Alexandrova_2014_Neurotoxicol_44_270 |
Author(s) : Alexandrova EA , Alkondon M , Aracava Y , Pereira EF , Albuquerque EX |
Ref : Neurotoxicology , 44 :270 , 2014 |
Abstract : |
PubMedSearch : Alexandrova_2014_Neurotoxicol_44_270 |
PubMedID: 25064080 |
Title : An acute exposure to a sub-lethal dose of soman triggers anxiety-related behavior in guinea pigs: interactions with acute restraint - Mamczarz_2010_Neurotoxicol_31_77 |
Author(s) : Mamczarz J , Pereira EF , Aracava Y , Adler M , Albuquerque EX |
Ref : Neurotoxicology , 31 :77 , 2010 |
Abstract : |
PubMedSearch : Mamczarz_2010_Neurotoxicol_31_77 |
PubMedID: 19883683 |
Title : Molecular and cellular actions of galantamine: clinical implications for treatment of organophosphorus poisoning - Pereira_2010_J.Mol.Neurosci_40_196 |
Author(s) : Pereira EF , Aracava Y , Alkondon M , Akkerman M , Merchenthaler I , Albuquerque EX |
Ref : Journal of Molecular Neuroscience , 40 :196 , 2010 |
Abstract : |
PubMedSearch : Pereira_2010_J.Mol.Neurosci_40_196 |
PubMedID: 19690988 |
Title : Magnetic resonance imaging reveals that galantamine prevents structural brain damage induced by an acute exposure of guinea pigs to soman - Gullapalli_2010_Neurotoxicol_31_67 |
Author(s) : Gullapalli RP , Aracava Y , Zhuo J , Helal Neto E , Wang J , Makris G , Merchenthaler I , Pereira EF , Albuquerque EX |
Ref : Neurotoxicology , 31 :67 , 2010 |
Abstract : |
PubMedSearch : Gullapalli_2010_Neurotoxicol_31_67 |
PubMedID: 19782102 |
Title : Pretreatment of Guinea pigs with galantamine prevents immediate and delayed effects of soman on inhibitory synaptic transmission in the hippocampus - Alexandrova_2010_J.Pharmacol.Exp.Ther_334_1051 |
Author(s) : Alexandrova EA , Aracava Y , Pereira EF , Albuquerque EX |
Ref : Journal of Pharmacology & Experimental Therapeutics , 334 :1051 , 2010 |
Abstract : |
PubMedSearch : Alexandrova_2010_J.Pharmacol.Exp.Ther_334_1051 |
PubMedID: 20554906 |
Title : Effectiveness of donepezil, rivastigmine, and (+\/-)huperzine A in counteracting the acute toxicity of organophosphorus nerve agents: comparison with galantamine - Aracava_2009_J.Pharmacol.Exp.Ther_331_1014 |
Author(s) : Aracava Y , Pereira EF , Akkerman M , Adler M , Albuquerque EX |
Ref : Journal of Pharmacology & Experimental Therapeutics , 331 :1014 , 2009 |
Abstract : |
PubMedSearch : Aracava_2009_J.Pharmacol.Exp.Ther_331_1014 |
PubMedID: 19741148 |
Title : Acute toxicity of organophosphorus compounds in guinea pigs is sex- and age-dependent and cannot be solely accounted for by acetylcholinesterase inhibition - Fawcett_2009_J.Pharmacol.Exp.Ther_328_516 |
Author(s) : Fawcett WP , Aracava Y , Adler M , Pereira EF , Albuquerque EX |
Ref : Journal of Pharmacology & Experimental Therapeutics , 328 :516 , 2009 |
Abstract : |
PubMedSearch : Fawcett_2009_J.Pharmacol.Exp.Ther_328_516 |
PubMedID: 18984651 |
Title : A single in vivo application of cholinesterase inhibitors has neuron type-specific effects on nicotinic receptor activity in guinea pig hippocampus - Alkondon_2009_J.Pharmacol.Exp.Ther_328_69 |
Author(s) : Alkondon M , Aracava Y , Pereira EF , Albuquerque EX |
Ref : Journal of Pharmacology & Experimental Therapeutics , 328 :69 , 2009 |
Abstract : |
PubMedSearch : Alkondon_2009_J.Pharmacol.Exp.Ther_328_69 |
PubMedID: 18842705 |
Title : Effective countermeasure against poisoning by organophosphorus insecticides and nerve agents - Albuquerque_2006_Proc.Natl.Acad.Sci.U.S.A_103_13220 |
Author(s) : Albuquerque EX , Pereira EF , Aracava Y , Fawcett WP , Oliveira M , Randall WR , Hamilton TA , Kan RK , Romano JA, Jr. , Adler M |
Ref : Proc Natl Acad Sci U S A , 103 :13220 , 2006 |
Abstract : |
PubMedSearch : Albuquerque_2006_Proc.Natl.Acad.Sci.U.S.A_103_13220 |
PubMedID: 16914529 |
Title : Memantine blocks alpha7* nicotinic acetylcholine receptors more potently than n-methyl-D-aspartate receptors in rat hippocampal neurons - Aracava_2005_J.Pharmacol.Exp.Ther_312_1195 |
Author(s) : Aracava Y , Pereira EF , Maelicke A , Albuquerque EX |
Ref : Journal of Pharmacology & Experimental Therapeutics , 312 :1195 , 2005 |
Abstract : |
PubMedSearch : Aracava_2005_J.Pharmacol.Exp.Ther_312_1195 |
PubMedID: 15522999 |
Title : Spine density and dendritic branching pattern of hippocampal CA1 pyramidal neurons in neonatal rats chronically exposed to the organophosphate paraoxon - Santos_2004_Neurotoxicol_25_481 |
Author(s) : Santos HR , Cintra WM , Aracava Y , Maciel CM , Castro NG , Albuquerque EX |
Ref : Neurotoxicology , 25 :481 , 2004 |
Abstract : |
PubMedSearch : Santos_2004_Neurotoxicol_25_481 |
PubMedID: 15019311 |
Title : Design, synthesis, and pharmacological profile of novel fused pyrazolo[4,3-d]pyridine and pyrazolo[3,4-b][1,8]naphthyridine isosteres: a new class of potent and selective acetylcholinesterase inhibitors - Barreiro_2003_J.Med.Chem_46_1144 |
Author(s) : Barreiro EJ , Camara CA , Verli H , Brazil-Mas L , Castro NG , Cintra WM , Aracava Y , Rodrigues CR , Fraga CA |
Ref : Journal of Medicinal Chemistry , 46 :1144 , 2003 |
Abstract : |
PubMedSearch : Barreiro_2003_J.Med.Chem_46_1144 |
PubMedID: 12646025 |
Title : Low concentrations of pyridostigmine prevent soman-induced inhibition of GABAergic transmission in the central nervous system: involvement of muscarinic receptors - Santos_2003_J.Pharmacol.Exp.Ther_304_254 |
Author(s) : Santos MD , Pereira EF , Aracava Y , Castro NG , Fawcett WP , Randall WR , Albuquerque EX |
Ref : Journal of Pharmacology & Experimental Therapeutics , 304 :254 , 2003 |
Abstract : |
PubMedSearch : Santos_2003_J.Pharmacol.Exp.Ther_304_254 |
PubMedID: 12490599 |
Title : The nicotinic allosteric potentiating ligand galantamine facilitates synaptic transmission in the mammalian central nervous system - Santos_2002_Mol.Pharmacol_61_1222 |
Author(s) : Santos MD , Alkondon M , Pereira EF , Aracava Y , Eisenberg HM , Maelicke A , Albuquerque EX |
Ref : Molecular Pharmacology , 61 :1222 , 2002 |
Abstract : |
PubMedSearch : Santos_2002_Mol.Pharmacol_61_1222 |
PubMedID: 11961141 |
Title : A novel thienylhydrazone, (2-thienylidene)3,4-methylenedioxybenzoylhydrazine, increases inotropism and decreases fatigue of skeletal muscle - Gonzalez-Serratos_2001_J.Pharmacol.Exp.Ther_299_558 |
Author(s) : Gonzalez-Serratos H , Chang R , Pereira EF , Castro NG , Aracava Y , Melo PA , Lima PC , Fraga CA , Barreiro EJ , Albuquerque EX |
Ref : Journal of Pharmacology & Experimental Therapeutics , 299 :558 , 2001 |
Abstract : |
PubMedSearch : Gonzalez-Serratos_2001_J.Pharmacol.Exp.Ther_299_558 |
PubMedID: 11602667 |
Title : Low concentrations of the organophosphate VX affect spontaneous and evoked transmitter release from hippocampal neurons: toxicological relevance of cholinesterase-independent actions - Rocha_1999_Toxicol.Appl.Pharmacol_159_31 |
Author(s) : Rocha ES , Santos MD , Chebabo SR , Aracava Y , Albuquerque EX |
Ref : Toxicol Appl Pharmacol , 159 :31 , 1999 |
Abstract : |
PubMedSearch : Rocha_1999_Toxicol.Appl.Pharmacol_159_31 |
PubMedID: 10448123 |
Title : An analysis of low level doses of cholinesterase inhibitors in cultured neurons and hippocampal slices of rats - Rocha_1998_Drug.Chem.Toxicol_21 Suppl 1_191 |
Author(s) : Rocha ES , Chebabo SR , Santos MD , Aracava Y , Albuquerque EX |
Ref : Drug & Chemical Toxicology , 21 Suppl 1 :191 , 1998 |
Abstract : |
PubMedSearch : Rocha_1998_Drug.Chem.Toxicol_21 Suppl 1_191 |
PubMedID: 10028411 |
Title : Methamidophos: an anticholinesterase without significant effects on postsynaptic receptors or transmitter release - Camara_1997_Neurotoxicol_18_589 |
Author(s) : Camara AL , Braga MF , Rocha ES , Santos MD , Cortes WS , Cintra WM , Aracava Y , Maelicke A , Albuquerque EX |
Ref : Neurotoxicology , 18 :589 , 1997 |
Abstract : |
PubMedSearch : Camara_1997_Neurotoxicol_18_589 |
PubMedID: 9291508 |
Title : Properties of neuronal nicotinic acetylcholine receptors: pharmacological characterization and modulation of synaptic function - |
Author(s) : Albuquerque EX , Alkondon M , Pereira EF , Castro NG , Schrattenholz A , Barbosa CT , Bonfante-Cabarcas R , Aracava Y , Eisenberg HM , Maelicke A |
Ref : Journal of Pharmacology & Experimental Therapeutics , 280 :1117 , 1997 |
PubMedID: 9067295 |
Title : Glycine and calcium-dependent effects of lead on N-methyl-D-aspartate receptor function in rat hippocampal neurons - Marchioro_1996_J.Pharmacol.Exp.Ther_279_143 |
Author(s) : Marchioro M , Swanson KL , Aracava Y , Albuquerque EX |
Ref : Journal of Pharmacology & Experimental Therapeutics , 279 :143 , 1996 |
Abstract : |
PubMedSearch : Marchioro_1996_J.Pharmacol.Exp.Ther_279_143 |
PubMedID: 8858987 |
Title : Ligand-gated ion channels in acutely dissociated rat hippocampal neurons with long dendrites - Barbosa_1996_Neurosci.Lett_210_177 |
Author(s) : Barbosa CT , Alkondon M , Aracava Y , Maelicke A , Albuquerque EX |
Ref : Neuroscience Letters , 210 :177 , 1996 |
Abstract : |
PubMedSearch : Barbosa_1996_Neurosci.Lett_210_177 |
PubMedID: 8805124 |
Title : Paraoxon: cholinesterase-independent stimulation of transmitter release and selective block of ligand-gated ion channels in cultured hippocampal neurons - Rocha_1996_J.Pharmacol.Exp.Ther_278_1175 |
Author(s) : Rocha ES , Swanson KL , Aracava Y , Goolsby JE , Maelicke A , Albuquerque EX |
Ref : Journal of Pharmacology & Experimental Therapeutics , 278 :1175 , 1996 |
Abstract : |
PubMedSearch : Rocha_1996_J.Pharmacol.Exp.Ther_278_1175 |
PubMedID: 8819500 |
Title : Pyrazole, an alcohol dehydrogenase inhibitor, has dual effects on N-methyl-D-aspartate receptors of hippocampal pyramidal cells: agonist and noncompetitive antagonist - Pereira_1992_J.Pharmacol.Exp.Ther_261_331 |
Author(s) : Pereira EF , Aracava Y , Aronstam RS , Barreiro EJ , Albuquerque EX |
Ref : Journal of Pharmacology & Experimental Therapeutics , 261 :331 , 1992 |
Abstract : |
PubMedSearch : Pereira_1992_J.Pharmacol.Exp.Ther_261_331 |
PubMedID: 1313873 |
Title : Sensitivity of N-methyl-D-aspartate (NMDA) and nicotinic acetylcholine receptors to ethanol and pyrazole - |
Author(s) : Aracava Y , Froes-Ferrao MM , Pereira EF , Albuquerque EX |
Ref : Annals of the New York Academy of Sciences , 625 :451 , 1991 |
PubMedID: 1711814 |
Title : Functional properties of the nicotinic and glutamatergic receptors - Albuquerque_1991_J.Recept.Res_11_603 |
Author(s) : Albuquerque EX , Costa AC , Alkondon M , Shaw KP , Ramoa AS , Aracava Y |
Ref : J Recept Res , 11 :603 , 1991 |
Abstract : |
PubMedSearch : Albuquerque_1991_J.Recept.Res_11_603 |
PubMedID: 1715922 |
Title : The anticonvulsant MK-801 interacts with peripheral and central nicotinic acetylcholine receptor ion channels - Ramoa_1990_J.Pharmacol.Exp.Ther_254_71 |
Author(s) : Ramoa AS , Alkondon M , Aracava Y , Irons J , Lunt GG , Deshpande SS , Wonnacott S , Aronstam RS , Albuquerque EX |
Ref : Journal of Pharmacology & Experimental Therapeutics , 254 :71 , 1990 |
Abstract : |
PubMedSearch : Ramoa_1990_J.Pharmacol.Exp.Ther_254_71 |
PubMedID: 1694895 |
Title : Activation and blockade of the acetylcholine receptor-ion channel by the agonists (+)-anatoxin-a, the N-methyl derivative and the enantiomer - Kofuji_1990_J.Pharmacol.Exp.Ther_252_517 |
Author(s) : Kofuji P , Aracava Y , Swanson KL , Aronstam RS , Rapoport H , Albuquerque EX |
Ref : Journal of Pharmacology & Experimental Therapeutics , 252 :517 , 1990 |
Abstract : |
PubMedSearch : Kofuji_1990_J.Pharmacol.Exp.Ther_252_517 |
PubMedID: 1690292 |
Title : Molecular effects of dimethylanatoxin on the peripheral nicotinic acetylcholine receptor - Costa_1990_J.Pharmacol.Exp.Ther_252_507 |
Author(s) : Costa AC , Swanson KL , Aracava Y , Aronstam RS , Albuquerque EX |
Ref : Journal of Pharmacology & Experimental Therapeutics , 252 :507 , 1990 |
Abstract : |
PubMedSearch : Costa_1990_J.Pharmacol.Exp.Ther_252_507 |
PubMedID: 1690291 |
Title : N-methylanatoxinol isomers: derivatives of the agonist (+)-anatoxin-a block the nicotinic acetylcholine receptor ion channel - Swanson_1989_Mol.Pharmacol_35_223 |
Author(s) : Swanson KL , Aracava Y , Sardina FJ , Rapoport H , Aronstam RS , Albuquerque EX |
Ref : Molecular Pharmacology , 35 :223 , 1989 |
Abstract : |
PubMedSearch : Swanson_1989_Mol.Pharmacol_35_223 |
PubMedID: 2465486 |
Title : Agonist recognition site of the peripheral acetylcholine receptor ion channel complex differentiates the enantiomers of nicotine - Rozental_1989_J.Pharmacol.Exp.Ther_251_395 |
Author(s) : Rozental R , Aracava Y , Scoble GT , Swanson KL , Wonnacott S , Albuquerque EX |
Ref : Journal of Pharmacology & Experimental Therapeutics , 251 :395 , 1989 |
Abstract : |
PubMedSearch : Rozental_1989_J.Pharmacol.Exp.Ther_251_395 |
PubMedID: 2478693 |
Title : Structure-activity relationship of reversible cholinesterase inhibitors: activation, channel blockade and stereospecificity of the nicotinic acetylcholine receptor-ion channel complex - Albuquerque_1988_Braz.J.Med.Biol.Res_21_1173 |
Author(s) : Albuquerque EX , Aracava Y , Cintra WM , Brossi A , Schonenberger B , Deshpande SS |
Ref : Brazilian Journal of Medical & Biological Research , 21 :1173 , 1988 |
Abstract : |
PubMedSearch : Albuquerque_1988_Braz.J.Med.Biol.Res_21_1173 |
PubMedID: 3074841 |
Title : The molecular basis of anticholinesterase actions on nicotinic and glutamatergic synapses - |
Author(s) : Aracava Y , Deshpande SS , Rickett DL , Brossi A , Schonenberger B , Albuquerque EX |
Ref : Annals of the New York Academy of Sciences , 505 :226 , 1987 |
PubMedID: 2446549 |
Title : Nicotinic acetylcholine receptors in cultured neurons from the hippocampus and brain stem of the rat characterized by single channel recording - Aracava_1987_FEBS.Lett_222_63 |
Author(s) : Aracava Y , Deshpande SS , Swanson KL , Rapoport H , Wonnacott S , Lunt G , Albuquerque EX |
Ref : FEBS Letters , 222 :63 , 1987 |
Abstract : |
PubMedSearch : Aracava_1987_FEBS.Lett_222_63 |
PubMedID: 2443390 |
Title : Noncompetitive blockade of the nicotinic acetylcholine receptor-ion channel complex by an irreversible cholinesterase inhibitor - Rao_1987_J.Pharmacol.Exp.Ther_240_337 |
Author(s) : Rao KS , Aracava Y , Rickett DL , Albuquerque EX |
Ref : Journal of Pharmacology & Experimental Therapeutics , 240 :337 , 1987 |
Abstract : |
PubMedSearch : Rao_1987_J.Pharmacol.Exp.Ther_240_337 |
PubMedID: 2433427 |
Title : A possible involvement of cyclic AMP in the expression of desensitization of the nicotinic acetylcholine receptor. A study with forskolin and its analogs - Albuquerque_1986_FEBS.Lett_199_113 |
Author(s) : Albuquerque EX , Deshpande SS , Aracava Y , Alkondon M , Daly JW |
Ref : FEBS Letters , 199 :113 , 1986 |
Abstract : |
PubMedSearch : Albuquerque_1986_FEBS.Lett_199_113 |
PubMedID: 2420646 |
Title : Activation and Inhibition of the Nicotinic Receptor: Actions of Physostigmine, Pyridostigmine and Meproadifen - |
Author(s) : Albuquerque EX , Allen CN , Aracava Y , Akaike A , Shaw KP , Rickett DL |
Ref : Advances in Behavioral Biology , 30 :677 , 1986 |
PubMedID: |
Title : Multiple actions of anticholinesterase agents on chemosensitive synapses: molecular basis for prophylaxis and treatment of organophosphate poisoning - Albuquerque_1985_Fundam.Appl.Toxicol_5_S182 |
Author(s) : Albuquerque EX , Deshpande SS , Kawabuchi M , Aracava Y , Idriss M , Rickett DL , Boyne AF |
Ref : Fundamental & Applied Toxicology , 5 :S182 , 1985 |
Abstract : |
PubMedSearch : Albuquerque_1985_Fundam.Appl.Toxicol_5_S182 |
PubMedID: 2868960 |
Title : The acetylcholine receptor of the neuromuscular junction recognizes mecamylamine as a noncompetitive antagonist - Varanda_1985_Mol.Pharmacol_28_128 |
Author(s) : Varanda WA , Aracava Y , Sherby SM , VanMeter WG , Eldefrawi ME , Albuquerque EX |
Ref : Molecular Pharmacology , 28 :128 , 1985 |
Abstract : |
PubMedSearch : Varanda_1985_Mol.Pharmacol_28_128 |
PubMedID: 2410768 |
Title : The reversible cholinesterase inhibitor physostigmine has channel-blocking and agonist effects on the acetylcholine receptor-ion channel complex - Shaw_1985_Mol.Pharmacol_28_527 |
Author(s) : Shaw KP , Aracava Y , Akaike A , Daly JW , Rickett DL , Albuquerque EX |
Ref : Molecular Pharmacology , 28 :527 , 1985 |
Abstract : |
PubMedSearch : Shaw_1985_Mol.Pharmacol_28_527 |
PubMedID: 2417099 |
Title : Meproadifen enhances activation and desensitization of the acetylcholine receptor-ionic channel complex (AChR): single channel studies - Aracava_1984_FEBS.Lett_174_267 |
Author(s) : Aracava Y , Albuquerque EX |
Ref : FEBS Letters , 174 :267 , 1984 |
Abstract : |
PubMedSearch : Aracava_1984_FEBS.Lett_174_267 |
PubMedID: 6088290 |
Title : Interactions of bupivacaine with ionic channels of the nicotinic receptor. Analysis of single-channel currents - Aracava_1984_Mol.Pharmacol_26_304 |
Author(s) : Aracava Y , Ikeda SR , Daly JW , Brookes N , Albuquerque EX |
Ref : Molecular Pharmacology , 26 :304 , 1984 |
Abstract : |
PubMedSearch : Aracava_1984_Mol.Pharmacol_26_304 |
PubMedID: 6090885 |
Title : Interactions of bupivacaine with ionic channels of the nicotinic receptor. Electrophysiological and biochemical studies - Ikeda_1984_Mol.Pharmacol_26_293 |
Author(s) : Ikeda SR , Aronstam RS , Daly JW , Aracava Y , Albuquerque EX |
Ref : Molecular Pharmacology , 26 :293 , 1984 |
Abstract : |
PubMedSearch : Ikeda_1984_Mol.Pharmacol_26_293 |
PubMedID: 6090884 |