Ali_2010_Bioorg.Med.Chem.Lett_20_7064

Reference

Title : Substituted spiro [2.3'] oxindolespiro [3.2'']-5,6-dimethoxy-indane-1''-one-pyrrolidine analogue as inhibitors of acetylcholinesterase - Ali_2010_Bioorg.Med.Chem.Lett_20_7064
Author(s) : Ali MA , Ismail R , Choon TS , Yoon YK , Wei AC , Pandian S , Kumar RS , Osman H , Manogaran E
Ref : Bioorganic & Medicinal Chemistry Lett , 20 :7064 , 2010
Abstract :

Series of pyrolidine analogues were synthesized and examined as acetylcholinesterase (AChE) inhibitors. Among the compounds, compounds 4k and 6k were the most potent inhibitors of the series. Compound 4k, showed potent inhibitory activity against acetyl cholinesterase enzyme with IC(50) 0.10 mumol/L. Pyrolidine analogues might be potential acetyl cholinesterase agents for AD.

PubMedSearch : Ali_2010_Bioorg.Med.Chem.Lett_20_7064
PubMedID: 20951037

Related information

Citations formats

Ali MA, Ismail R, Choon TS, Yoon YK, Wei AC, Pandian S, Kumar RS, Osman H, Manogaran E (2010)
Substituted spiro [2.3'] oxindolespiro [3.2'']-5,6-dimethoxy-indane-1''-one-pyrrolidine analogue as inhibitors of acetylcholinesterase
Bioorganic & Medicinal Chemistry Lett 20 :7064

Ali MA, Ismail R, Choon TS, Yoon YK, Wei AC, Pandian S, Kumar RS, Osman H, Manogaran E (2010)
Bioorganic & Medicinal Chemistry Lett 20 :7064