| Title : A facile ionic liquid promoted synthesis, cholinesterase inhibitory activity and molecular modeling study of novel highly functionalized spiropyrrolidines - Almansour_2015_Molecules_20_2296 |
| Author(s) : Almansour AI , Kumar RS , Arumugam N , Basiri A , Kia Y , Ali MA , Farooq M , Murugaiyah V |
| Ref : Molecules , 20 :2296 , 2015 |
|
Abstract :
A series of novel dimethoxyindanone embedded spiropyrrolidines were synthesized in ionic liquid, [bmim]Br and were evaluated for their inhibitory activities towards cholinesterases. Among the spiropyrrolidines, compound 4f exhibited the most potent activity with an IC50 value of 1.57 microM against acethylcholinesterase (AChE). Molecular docking simulation for the most active compound was employed with the aim of disclosing its binding mechanism to the active site of AChE receptor. |
| PubMedSearch : Almansour_2015_Molecules_20_2296 |
| PubMedID: 25642838 |
Almansour AI, Kumar RS, Arumugam N, Basiri A, Kia Y, Ali MA, Farooq M, Murugaiyah V (2015)
A facile ionic liquid promoted synthesis, cholinesterase inhibitory activity and molecular modeling study of novel highly functionalized spiropyrrolidines
Molecules
20 :2296
Almansour AI, Kumar RS, Arumugam N, Basiri A, Kia Y, Ali MA, Farooq M, Murugaiyah V (2015)
Molecules
20 :2296