| Title : Palmitoyl-Protein Thioesterase 1 (PPT1) Protein, Linked to Neuronal Ceroid Lipofuscinosis 1, Is a Major Constituent of Ageing-Related Human Neuronal Lipofuscin - Anstotz_2025_Neuropathol.Appl.Neurobiol_51_e70043 |
| Author(s) : Anstotz M , Tschirner S , May C , Kosters S , Martin C , Caspers S , Aronica E , Bidmon HJ , Marcus K , Korth C |
| Ref : Neuropathol Appl Neurobiol , 51 :e70043 , 2025 |
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Abstract :
Proteomics of laser-dissected lipofuscin from aged, healthy brains reveals Palmitoyl-Protein Thioesterase 1 (PPT1) and other CLN proteins as constituents. PPT1 is increasingly sequestered to lipofuscin during ageing. Protein sequestering into lipofuscin may contribute to physiological neuronal ageing. |
| PubMedSearch : Anstotz_2025_Neuropathol.Appl.Neurobiol_51_e70043 |
| PubMedID: 40990621 |
| Gene_locus related to this paper: human-PPT1 |
| Gene_locus | human-PPT1 |
Anstotz M, Tschirner S, May C, Kosters S, Martin C, Caspers S, Aronica E, Bidmon HJ, Marcus K, Korth C (2025)
Palmitoyl-Protein Thioesterase 1 (PPT1) Protein, Linked to Neuronal Ceroid Lipofuscinosis 1, Is a Major Constituent of Ageing-Related Human Neuronal Lipofuscin
Neuropathol Appl Neurobiol
51 :e70043
Anstotz M, Tschirner S, May C, Kosters S, Martin C, Caspers S, Aronica E, Bidmon HJ, Marcus K, Korth C (2025)
Neuropathol Appl Neurobiol
51 :e70043