| Title : Structural analysis of a hormone-bound Striga strigolactone receptor - Arellano-Saab_2023_Nat.Plants_9_883 |
| Author(s) : Arellano-Saab A , Skarina T , Xu Z , McErlean CSP , Savchenko A , Lumba S , Stogios PJ , McCourt P |
| Ref : Nat Plants , 9 :883 , 2023 |
|
Abstract :
Strigolactones (SLs) regulate many aspects of plant development, but ambiguities remain about how this hormone is perceived because SL-complexed receptor structures do not exist. We find that when SL binds the Striga receptor, ShHTL5, a series of conformational changes relative to the unbound state occur, but these events are not sufficient for signalling. Ligand-complexed receptors, however, form internal tunnels that posit an explanation for how SL exits its receptor after hydrolysis. |
| PubMedSearch : Arellano-Saab_2023_Nat.Plants_9_883 |
| PubMedID: 37264151 |
| Gene_locus related to this paper: strhe-ShHTL5 |
| Substrate | GR24 |
| Gene_locus | strhe-ShHTL5 |
| Structure | 8DVC |
Arellano-Saab A, Skarina T, Xu Z, McErlean CSP, Savchenko A, Lumba S, Stogios PJ, McCourt P (2023)
Structural analysis of a hormone-bound Striga strigolactone receptor
Nat Plants
9 :883
Arellano-Saab A, Skarina T, Xu Z, McErlean CSP, Savchenko A, Lumba S, Stogios PJ, McCourt P (2023)
Nat Plants
9 :883