Babota_2023_Antioxidants.(Basel)_12_

Reference

Title : Thymus Species from Romanian Spontaneous Flora as Promising Source of Phenolic Secondary Metabolites with Health-Related Benefits - Babota_2023_Antioxidants.(Basel)_12_
Author(s) : Babota M , Frumuzachi O , Nicolescu A , Dias MI , Pinela J , Barros L , Anibarro-Ortega M , Stojkovic D , Carevic T , Mocan A , Lopez V , Crian G
Ref : Antioxidants (Basel) , 12 : , 2023
Abstract :

Wild thyme aerial parts (Serpylli herba) are recognized as a valuable herbal product with antioxidant, anti-inflammatory, and antibacterial effects. Although pharmacopoeial regulations allow its collection exclusively from Thymus serpyllum, substitution with other species is frequent in current practice. This study analyzed the phenolic composition, antioxidant, and enzyme-inhibitory and antimicrobial activity of the hydroethanolic extracts obtained from five Romanian wild thyme species (Thymus alpestris, T. glabrescens, T. panonicus, T. pulcherimus and T. pulegioides). The analysis of individual phenolic constituents was performed through LC-ESI-DAD/MS(2), while for the in vitro evaluation of antioxidant potential, TEAC, FRAP, DPPH, TBARS and OxHLIA assays were employed. The anti-enzymatic potential was tested in vitro against tyrosinase, alpha-glucosidase and acetylcholinesterase. High rosmarinic acid contents were quantified in all species (20.06 +/- 0.32-80.49 +/- 0.001 mg/g dry extract); phenolic acids derivatives (including salvianolic acids) were confirmed as the principal metabolites of T. alpestris and T. glabrescens, while eriodictyol-O-di-hexoside was found exclusively in T. alpestris. All species showed strong antioxidant potential and moderate anti-enzymatic effect against alpha-glucosidase and acetylcholinesterase, showing no anti-tyrosinase activity. This is the first detailed report on the chemical and biological profile of T. alpestris collected from Romanian spontaneous flora.

PubMedSearch : Babota_2023_Antioxidants.(Basel)_12_
PubMedID: 36829949

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Citations formats

Babota M, Frumuzachi O, Nicolescu A, Dias MI, Pinela J, Barros L, Anibarro-Ortega M, Stojkovic D, Carevic T, Mocan A, Lopez V, Crian G (2023)
Thymus Species from Romanian Spontaneous Flora as Promising Source of Phenolic Secondary Metabolites with Health-Related Benefits
Antioxidants (Basel) 12 :

Babota M, Frumuzachi O, Nicolescu A, Dias MI, Pinela J, Barros L, Anibarro-Ortega M, Stojkovic D, Carevic T, Mocan A, Lopez V, Crian G (2023)
Antioxidants (Basel) 12 :