| Title : Sciatic nerve neuropathy target esterase. Methods of assay, proximo-distal distribution and regeneration - Barril_1988_Toxicology_49_107 |
| Author(s) : Barril JB , Vilanova E , Pellin MC |
| Ref : Toxicology , 49 :107 , 1988 |
| Abstract : Some organophosphorus compounds (OP) induce a delayed polyneuropathy (OPIDP) which is initiated by the phosphorylation of the so-called neuropathy target esterase (NTE). In this work some aspects of hen sciatic nerve NTE are studied. The assay method is reported and modifications are discussed and a combined method proposed. Proximo-distal distribution showed a significant difference from proximal (100 +/- 10%) to distal (69 +/- 9%) fragments, in accordance with reported data. The time course of in vivo regeneration after a single TOCP dose (200 mg/kg, post oral) showed some differences when compared with hen brain NTE. Sciatic nerve NTE showed a delay of 2-3 days before regeneration but then regenerated faster (74% activity at day 7) than brain NTE (50% activity at day 7). A slower rate of regeneration of distal than proximal segments has been suggested to explain higher sensitivity of distal segments [3], however in this work no significant differences were observed in the rate of regeneration when comparing proximal and distal fragments. |
| ESTHER : Barril_1988_Toxicology_49_107 |
| PubMedSearch : Barril_1988_Toxicology_49_107 |
| PubMedID: 3376120 |
Barril JB, Vilanova E, Pellin MC (1988)
Sciatic nerve neuropathy target esterase. Methods of assay, proximo-distal distribution and regeneration
Toxicology
49 :107
Barril JB, Vilanova E, Pellin MC (1988)
Toxicology
49 :107