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Benderly_2016_Biomarkers__1

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Title : Lipoprotein-associated phospholipase A, and subsequent cardiovascular events and mortality among patients with coronary heart disease - Benderly_2016_Biomarkers__1
Author(s) : Benderly M , Sapir B , Kalter-Leibovici O , Zimlichman R
Ref : Biomarkers , :1 , 2016
Abstract :

OBJECTIVE: The objective of this study is to evaluate the relevance of Lp-PLA2 to risk prediction among coronary heart disease (CHD) patients.
METHODS: Lp-PLA2 activity was measured in 2538 CHD patients included in the Bezafibrate Infarction Prevention (BIP) study.
RESULTS: Adjusting for patient characteristics and traditional risk factors, 1 standard deviation of Lp-PLA2 was associated with a hazard ratio (HR) of 1.12 (95% confidence interval (CI): 1.00-1.25) for mortality and 1.03 (0.93-1.14) for cardiovascular events. Lp-PLA2 did not significantly improve model discrimination, or calibration nor result in noteworthy reclassification.
CONCLUSIONS: Our results do not support added value of Lp-PLA2 for predicting cardiovascular events or mortality among CHD patients beyond traditional risk factor.
PubMedSearch : Benderly_2016_Biomarkers__1
PubMedID: 27097870
Gene_locus related to this paper: human-PLA2G7

Related information

Gene_locus human-PLA2G7

Citations formats

Benderly M, Sapir B, Kalter-Leibovici O, Zimlichman R (2016)
Lipoprotein-associated phospholipase A, and subsequent cardiovascular events and mortality among patients with coronary heart disease
Biomarkers :1

Benderly M, Sapir B, Kalter-Leibovici O, Zimlichman R (2016)
Biomarkers :1