human-PLA2G7

Homo sapiens (Human) plasma PAF acetylhydrolase Phospholipase A2 groupe 7 PLA2G7 PAFAH PAF-AH Lp-PLA(2)

Comment

The PLA2G7 (PAFAH) gene encodes platelet-activating factor (PAF) (Lipoprotein-associated phospholipase A2) acetylhydrolase (EC 3.1.1.47), a secreted enzyme that catalyzes the degradation of PAF to inactive products by hydrolysis of the acetyl group at the sn-2 position, producing the biologically inactive products LYSO-PAF and acetate. Plasma platelet-activating factor acetylhydrolase deficiency is inherited in an autosomal recessive manner (Stafforini et al., 1996) due to mutation of PLA2G7. Kruse et al. (2000) identified PLA2G7 variants on Chromosome 6p21.2 associated with atopy and asthma in a Caucasian population: the variant thr198 allele (I198T\; 601690.0002) was highly associated with total IgE (147050) concentrations in an atopic population and with asthma in an asthmatic population\; and the variant val379 allele (A379V\; 601690.0003) was found to be highly associated with specific sensitization in the atopic population and with asthma in an asthmatic population. (Previously named human-pafa. Other names: 1-alkyl-2-acetylglycerophosphocholine esterase 2-acetyl-1-alkylglycerophosphocholine esterase Group-VIIA phospholipase A2, gVIIA-PLA2, LDL-associated phospholipase A2, LDL-PLA(2), Lp-PLA2). A rationally designed mutant (W298H<\/A>) of plasma platelet-activating factor acetylhydrolase PLA2G7, which hydrolyzes the organophosphorus nerve agent soman is published by Kirby et al.<\/A> A positive correlation with PLA2G7 levels has been found in certain disease states, including cardiovascular disorders, dementia,4 diabetic macular edema5 and prostate cancer. Consequently, inhibitors of PLA2G7 have been clinically investigated in atherosclerosis and Alzheimer's disease. Alternative names: 1-alkyl-2-acetylglycerophosphocholine esterase, 2-acetyl-1-alkylglycerophosphocholine esterase, Group-VIIA phospholipase A2 (gVIIA-PLA2), LDL-associated phospholipase A2 (LDL-PLA(2))

Relationship

Family : PAF-Acetylhydrolase

Block : X

Position in NCBI Life Tree : Homo sapiens

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Primates N E > Haplorrhini N E > Simiiformes N E > Catarrhini N E > Hominoidea N E > Hominidae N E > Homininae N E > Homo N E > Homo sapiens N E

Molecular evidence

No mutation

6M08 - Crystal structure of Lp-PLA2 in complex with a novel covalent inhibitor 6M08-BWO compound 7 6M07 - Crystal structure of Lp-PLA2 in complex with a novel covalent inhibitor 6M07-BWO compound 8 6M06 - Crystal structure of Lp-PLA2 in complex with a novel covalent inhibitor 6M06-BWF Compound 5 5LP1 - Crystal structure of human lipoprotein-associated phospholipase A2 in complex with a [1.1.1]bicyclopentane- containing inhibitor at 1.91 A resolution 5YEA - The crystal structure of human Lp-PLA2 in complex with a novel inhibitor 5YE9 - The crystal structure of human Lp-PLA2 in complex with a novel inhibitor 5YE8 - The crystal structure of human Lp-PLA2 in complex with a novel inhibitor 5YE7 - The crystal structure of human Lp-PLA2 in complex with a novel inhibitor 5I8P - Crystal structure of human LP_PLA2 in complex with novel inhibitor 5I9I - Crystal structure of human LP_PLA2 in complex with Darapladib 5LYY - Fragment-based inhibitors of human Lipoprotein associated Phospholipase A2 CHEMBL3908555 5LZ2 - Fragment-based inhibitors of human Lipoprotein associated Phospholipase A2 3-cyano-N-cyclopropylbenzenesulfonamide 5LZ4 - Fragment-based inhibitors of human Lipoprotein associated Phospholipase A2 CHEMBL3975283 5LZ5 - Fragment-based inhibitors of human Lipoprotein associated Phospholipase A2 CHEMBL3983270 5LZ7 - Fragment-based inhibitors of human Lipoprotein associated Phospholipase A2 5LZ8 - Fragment-based inhibitors of human Lipoprotein associated Phospholipase A2 5LZ9 - Fragment-based inhibitors of human Lipoprotein associated Phospholipase A2 5JAD - Compound binding to human Lipoprotein-associated Phospholipase A2 (Lp-PLA2)discovered through fragment screening 5JAH - Exploitation of a novel binding pocket in human Lipoprotein-associated Phospholipase A2 (Lp-PLA2) discovered through X-Ray fragment screening 5JAL - Exploitation of a novel binding pocket in human Lipoprotein-associated Phospholipase A2 (Lp-PLA2) discovered through X-Ray fragment screening 5JAN - Exploitation of a novel binding pocket in human Lipoprotein-associated Phospholipase A2 (Lp-PLA2) discovered through X-Ray fragment screening 5JAO - Exploitation of a novel binding pocket in human Lipoprotein-associated Phospholipase A2 (Lp-PLA2) discovered through X-Ray fragment screening 5JAP - Exploitation of a novel binding pocket in human Lipoprotein-associated Phospholipase A2 (Lp-PLA2) discovered through X-Ray fragment screening 5JAR - Exploitation of a novel binding pocket in human Lipoprotein-associated Phospholipase A2 (Lp-PLA2) discovered through X-Ray fragment screening 5JAS - Exploitation of a novel binding pocket in human Lipoprotein-associated Phospholipase A2 (Lp-PLA2) discovered through X-Ray fragment screening 5JAT - Exploitation of a novel binding pocket in human Lipoprotein-associated Phospholipase A2 (Lp-PLA2) discovered through X-Ray fragment screening 5JAU - Exploitation of a novel binding pocket in human Lipoprotein-associated Phospholipase A2 (Lp-PLA2) discovered through X-Ray fragment screening 3F96 - Crystal structure of human plasma platelet activating factor acetylhydrolase covalently inhibited by Sarin 3F97 - Crystal structure of human plasma platelet activating factor acetylhydrolase covalently inhibited by Soman 3F98 - Crystal structure of human plasma platelet activating factor acetylhydrolase covalently inhibited by Tabun 3F9C - Crystal structure of human plasma platelet activating factor acetylhydrolase covalently inhibited by Diisopropylfluorophosphate 3D59 - Crystal structure of human plasma platelet activating factor acetylhydrolase 3D5E - Crystal structure of human plasma platelet activating factor acetylhydrolase covalently inhibited by paraoxon

No kinetic

Sequence

Peptide

MVPPKLHVLF CLCGCLAVVY PFDWQYINPV AHMKSSAWVN KIQVLMAAAS FGQTKIPRGN GPYSVGCTDL MFDHTNKGTF LRLYYPSQDN DRLDTLWIPN KEYFWGLSKF LGTHWLMGNI LRLLFGSMTT PANWNSPLRP GEKYPLVVFS HGLGAFRTLY SAIGIDLASH GFIVAAVEHR DRSASATYYF KDQSAAEIGD KSWLYLRTLK QEEETHIRNE QVRQRAKECS QALSLILDID HGKPVKNALD LKFDMEQLKD SIDREKIAVI GHSFGGATVI QTLSEDQRFR CGIALDAWMF PLGDEVYSRI PQPLFFINSE YFQYPANIIK MKKCYSPDKE RKMITIRGSV HQNFADFTFA TGKIIGHMLK LKGDIDSNVA IDLSNKASLA FLQKHLGLHK DFDQWDCLIE GDDENLIPGT NINTTNQHIM LQNSSGIEKY N

References (99)

Title : Bioinformatics Analysis Identifies PLA2G7 as a Key Antigen-Presenting Prognostic Related Gene Promoting Hepatocellular Carcinoma through the STAT1\/PD-L1 Axis - Guo_2024_Front.Biosci.(Landmark.Ed)_29_39
Author(s) : Guo S , Yang Q
Ref : Front Biosci (Landmark Ed) , 29 :39 , 2024
PubMedID: 38287833
Gene_locus related to this paper: human-PLA2G7

Title : Inhibiting PLA2G7 reverses the immunosuppressive function of intratumoral macrophages and augments immunotherapy response in hepatocellular carcinoma - Zhang_2024_J.Immunother.Cancer_12_e008094
Author(s) : Zhang F , Liu W , Meng F , Jiang Q , Tang W , Liu Z , Lin X , Xue R , Zhang S , Dong L
Ref : J Immunother Cancer , 12 : , 2024
PubMedID: 38272562
Gene_locus related to this paper: human-PLA2G7

Title : Correlation of LP-PLA2 and MMP-9 with the occurrence of early neurological deterioration in patients with acute ischemic stroke - Yu_2024_Medicine.(Baltimore)_103_e38310
Author(s) : Yu B , Shi G , Yang F , Xu W
Ref : Medicine (Baltimore) , 103 :e38310 , 2024
PubMedID: 38788013
Gene_locus related to this paper: human-PLA2G7

Title : Lp-PLA2 silencing ameliorates inflammation and autophagy in nonalcoholic steatohepatitis through inhibiting the JAK2\/STAT3 pathway - Yao_2023_PeerJ_11_e15639
Author(s) : Yao J , Zhao Y
Ref : PeerJ , 11 :e15639 , 2023
PubMedID: 37397012
Gene_locus related to this paper: human-PLA2G7

Title : Lipoprotein-Associated Phospholipase A2 Activity as Potential Biomarker of Vascular Dementia - Zuliani_2023_Antioxidants.(Basel)_12_597
Author(s) : ZulianiZuliani G , Marsillach J , Trentini A , Rosta V , Cervellati C
Ref : Antioxidants (Basel) , 12 :597 , 2023
PubMedID: 36978845
Gene_locus related to this paper: human-PLA2G7

Title : PLA2G7\/PAF-AH as Potential Negative Regulator of the Wnt Signaling Pathway Mediates Protective Effects in BRCA1 Mutant Breast Cancer - Liao_2023_Int.J.Mol.Sci_24_882
Author(s) : Liao Y , Badmann S , Kraus F , Topalov NE , Mayr D , Kolben T , Hester A , Beyer S , Mahner S , Jeschke U , Trillsch F , Czogalla B , Burges A
Ref : Int J Mol Sci , 24 : , 2023
PubMedID: 36614323
Gene_locus related to this paper: human-PLA2G7

Title : Biological Properties and Clinical Significance of Lipoprotein-Associated Phospholipase A(2) in Ischemic Stroke - Zhang_2022_Cardiovasc.Ther_2022_3328574
Author(s) : Zhang S , Huang S , Hu D , Jiang F , Lv Y , Liu G
Ref : Cardiovasc Ther , 2022 :3328574 , 2022
PubMedID: 36313479
Gene_locus related to this paper: human-PLA2G7

Title : Association Lp-PLA2 Gene Polymorphisms with Coronary Heart Disease - Ma_2022_Dis.Markers_2022_9775699
Author(s) : Ma S , Ding L , Cai M , Chen L , Yan B , Yang J
Ref : Dis Markers , 2022 :9775699 , 2022
PubMedID: 35818585
Gene_locus related to this paper: human-PLA2G7

Title : Changes and significance of serum monocyte chemoattractant protein-1 and Lp-PLA2 in patients with hypertension and coronary heart disease - Tian_2022_J.Pak.Med.Assoc_72_1114
Author(s) : Tian Y , Fan Y , Chen L , Sun M
Ref : J Pak Med Assoc , 72 :1114 , 2022
PubMedID: 35751319
Gene_locus related to this paper: human-PLA2G7

Title : Profiling Active Enzymes for Polysorbate Degradation in Biotherapeutics by Activity-Based Protein Profiling - Li_2021_Anal.Chem_93_8161
Author(s) : Li X , Chandra D , Letarte S , Adam GC , Welch J , Yang RS , Rivera S , Bodea S , Dow A , Chi A , Strulson CA , Richardson DD
Ref : Analytical Chemistry , 93 :8161 , 2021
PubMedID: 34032423
Gene_locus related to this paper: human-PLA2G7

Title : Structural Modeling of Wild and Mutant Forms of Human Plasma Platelet Activating Factor-Acetyl Hydrolase Enzyme - Khan_2020_J.Inflamm.Res_13_1125
Author(s) : Khan MI , Hariprasad G
Ref : J Inflamm Res , 13 :1125 , 2020
PubMedID: 33364808
Gene_locus related to this paper: human-PLA2G7

Title : Identification of Highly Selective Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Inhibitors by a Covalent Fragment-Based Approach - Huang_2020_J.Med.Chem_63_7052
Author(s) : Huang F , Hu H , Wang K , Peng C , Xu W , Zhang Y , Gao J , Liu Y , Zhou H , Huang R , Li M , Shen J , Xu Y
Ref : Journal of Medicinal Chemistry , 63 :7052 , 2020
PubMedID: 32459096
Gene_locus related to this paper: human-PLA2G7

Title : Lipoprotein-associated phospholipase A2: The story continues - Huang_2020_Med.Res.Rev_40_79
Author(s) : Huang F , Wang K , Shen J
Ref : Med Res Rev , 40 :79 , 2020
PubMedID: 31140638
Gene_locus related to this paper: human-PLA2G7

Title : Phospholipase A2 is an Inflammatory Predictor in Cardiovascular Diseases: Is there any Spacious Room to Prove the Causation? - Santoso_2020_Curr.Cardiol.Rev_16_3
Author(s) : Santoso A , Heriansyah T , Rohman MS
Ref : Curr Cardiol Rev , 16 :3 , 2020
PubMedID: 31146670
Gene_locus related to this paper: human-PLA2G7

Title : The rs1051931 G>A Polymorphism in the PLA2G7 Gene Confers Resistance to Immunoglobulin Therapy in Kawasaki Disease in a Southern Chinese Population - Gu_2020_Front.Pediatr_8_338
Author(s) : Gu X , Lin W , Xu Y , Che D , Tan Y , Lu Z , Pi L , Fu L , Zhou H , Jiang Z
Ref : Front Pediatr , 8 :338 , 2020
PubMedID: 32656171
Gene_locus related to this paper: human-PLA2G7

Title : Lipoprotein-associated phospholipase A2 predicts cardiovascular events in dialyzed patients - De Mauri_2019_J.Nephrol_32_283
Author(s) : De Mauri A , Vidali M , Chiarinotti D , Bellomo G , Rolla R
Ref : J Nephrol , 32 :283 , 2019
PubMedID: 30168082
Gene_locus related to this paper: human-PLA2G7

Title : The association between the D166E polymorphism of the lipoprotein associated phospholipase A2 and risk of myocardial infarction - Zhang_2019_Eur.Rev.Med.Pharmacol.Sci_23_3960
Author(s) : Zhang MM , Zhang CG , Yang CJ , Zhao P , Li YL
Ref : Eur Rev Med Pharmacol Sci , 23 :3960 , 2019
PubMedID: 31115024
Gene_locus related to this paper: human-PLA2G7

Title : Lipoprotein-Associated Phospholipase A2 Activity and Mass as Independent Risk Factor of Stroke: A Meta-Analysis - Hu_2019_Biomed.Res.Int_2019_8642784
Author(s) : Hu G , Liu D , Tong H , Huang W , Hu Y , Huang Y
Ref : Biomed Res Int , 2019 :8642784 , 2019
PubMedID: 31236414
Gene_locus related to this paper: human-PLA2G7

Title : Interaction between nonsynonymous polymorphisms in PLA2G7 gene and smoking on the risk of coronary heart disease in a Chinese population - Chi_2018_J.Thromb.Thrombolysis_46_125
Author(s) : Chi Y , Shi C , Zhang X , Xi Y
Ref : J Thromb Thrombolysis , 46 :125 , 2018
PubMedID: 29728838
Gene_locus related to this paper: human-PLA2G7

Title : The Prognostic Value of Lipoprotein-Associated Phospholipase A(2) in the Long-Term Care of Patients With Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention - Yang_2018_Clin.Appl.Thromb.Hemost_24_822
Author(s) : Yang L , Wang H , Zhang Y , Han T , Wang W
Ref : Clin Appl Thromb Hemost , 24 :822 , 2018
PubMedID: 29121808
Gene_locus related to this paper: human-PLA2G7

Title : Pharmacogenetic meta-analysis of baseline risk factors, pharmacodynamic, efficacy and tolerability endpoints from two large global cardiovascular outcomes trials for darapladib - Yeo_2017_PLoS.One_12_e0182115
Author(s) : Yeo A , Li L , Warren L , Aponte J , Fraser D , King K , Johansson K , Barnes A , Macphee C , Davies R , Chissoe S , Tarka E , O'Donoghue ML , White HD , Wallentin L , Waterworth D
Ref : PLoS ONE , 12 :e0182115 , 2017
PubMedID: 28753643
Gene_locus related to this paper: human-PLA2G7

Title : Effects of overweight and the PLA2G7 V279F polymorphism on the association of age with systolic blood pressure - Kim_2017_PLoS.One_12_e0173611
Author(s) : Kim M , Yoo HJ , Jang HY , Lee SH , Lee JH
Ref : PLoS ONE , 12 :e0173611 , 2017
PubMedID: 28334001
Gene_locus related to this paper: human-PLA2G7

Title : Association of Lp-PLA2 G994T gene polymorphism with risk of ischemic stroke in Chinese population - Ni_2017_J.Biochem.Mol.Toxicol_31_
Author(s) : Ni J , Gu H , Hu W , Zhou F , Zhu X , Wang K
Ref : J Biochem Mol Toxicol , 31 : , 2017
PubMedID: 28960681
Gene_locus related to this paper: human-PLA2G7

Title : Structure-Guided Discovery of Novel, Potent, and Orally Bioavailable Inhibitors of Lipoprotein-Associated Phospholipase A2 - Liu_2017_J.Med.Chem_60_10231
Author(s) : Liu Q , Huang F , Yuan X , Wang K , Zou Y , Shen J , Xu Y
Ref : Journal of Medicinal Chemistry , 60 :10231 , 2017
PubMedID: 29193967
Gene_locus related to this paper: human-PLA2G7

Title : Investigation of a Bicyclo[1.1.1]pentane as a Phenyl Replacement within an LpPLA2 Inhibitor - Measom_2017_ACS.Med.Chem.Lett_8_43
Author(s) : Measom ND , Down KD , Hirst DJ , Jamieson C , Manas ES , Patel VK , Somers DO
Ref : ACS Med Chem Lett , 8 :43 , 2017
PubMedID: 28105273
Gene_locus related to this paper: human-PLA2G7

Title : Association between Lp-PLA2 and coronary heart disease in Chinese patients - Yang_2017_J.Int.Med.Res_45_159
Author(s) : Yang L , Liu Y , Wang S , Liu T , Cong H
Ref : J Internal Medicine Res , 45 :159 , 2017
PubMedID: 28222638
Gene_locus related to this paper: human-PLA2G7

Title : Associations between four types of single-nucleotide polymorphisms in PLA2G7 gene and clinical atherosclerosis: a meta-analysis - Santoso_2017_Am.J.Cardiovasc.Dis_7_122
Author(s) : Santoso A , Maulana R , Alzahra F , Maghfirah I , Putrinarita AD , Heriansyah T
Ref : Am J Cardiovasc Dis , 7 :122 , 2017
PubMedID: 29348973
Gene_locus related to this paper: human-PLA2G7

Title : Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Discovered through X-ray Fragment Screening - Woolford_2016_J.Med.Chem_59_5356
Author(s) : Woolford AJ , Pero JE , Aravapalli S , Berdini V , Coyle JE , Day PJ , Dodson AM , Grondin P , Holding FP , Lee LY , Li P , Manas ES , Marino J, Jr. , Martin AC , McCleland BW , McMenamin RL , Murray CW , Neipp CE , Page LW , Patel VK , Potvain F , Rich S , Rivero RA , Smith K , Somers DO , Trottet L , Velagaleti R , Williams G , Xie R
Ref : Journal of Medicinal Chemistry , 59 :5356 , 2016
PubMedID: 27167608
Gene_locus related to this paper: human-PLA2G7

Title : A phenome-wide association study of a lipoprotein-associated phospholipase A2 loss-of-function variant in 90 000 Chinese adults - Millwood_2016_Int.J.Epidemiol_45_1588
Author(s) : Millwood IY , Bennett DA , Walters RG , Clarke R , Waterworth D , Johnson T , Chen Y , Yang L , Guo Y , Bian Z , Hacker A , Yeo A , Parish S , Hill MR , Chissoe S , Peto R , Cardon L , Collins R , Li L , Chen Z
Ref : Int J Epidemiol , 45 :1588 , 2016
PubMedID: 27301456
Gene_locus related to this paper: human-PLA2G7

Title : Discovery of Potent and Orally Active Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Inhibitors as a Potential Therapy for Diabetic Macular Edema - Chen_2016_J.Med.Chem_59_2674
Author(s) : Chen X , Wang K , Xu W , Ma Q , Chen M , Du L , Mo M , Wang Y , Shen J
Ref : Journal of Medicinal Chemistry , 59 :2674 , 2016
PubMedID: 26927682
Gene_locus related to this paper: human-PLA2G7

Title : Val279Phe variant of Lp-PLA2 is a risk factor for a subpopulation of Indonesia patients with acute myocardial infarction - Cahyaningtias_2016_Genes.Dis_3_289
Author(s) : Cahyaningtias M , Rohman MS , Widodo , Wahjono Adi A , Yuda R , Indrayana Y , Putri JF , Rusdianto , Lukitasari M , Hendrawan D
Ref : Genes Dis , 3 :289 , 2016
PubMedID: 30258899
Gene_locus related to this paper: human-PLA2G7

Title : Lipoprotein-associated phospholipase A, and subsequent cardiovascular events and mortality among patients with coronary heart disease - Benderly_2016_Biomarkers__1
Author(s) : Benderly M , Sapir B , Kalter-Leibovici O , Zimlichman R
Ref : Biomarkers , :1 , 2016
PubMedID: 27097870
Gene_locus related to this paper: human-PLA2G7

Title : Fragment-Based Approach to the Development of an Orally Bioavailable Lactam Inhibitor of Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) - Woolford_2016_J.Med.Chem_59_10738
Author(s) : Woolford AJ , Day PJ , Beneton V , Berdini V , Coyle JE , Dudit Y , Grondin P , Huet P , Lee LY , Manas ES , McMenamin RL , Murray CW , Page LW , Patel VK , Potvain F , Rich SJ , Sang Y , Somers DO , Trottet L , Wan Z , Zhang X
Ref : Journal of Medicinal Chemistry , 59 :10738 , 2016
PubMedID: 27933945
Gene_locus related to this paper: human-PLA2G7

Title : Structural and Thermodynamic Characterization of Protein-Ligand Interactions Formed between Lipoprotein-Associated Phospholipase A2 and Inhibitors - Liu_2016_J.Med.Chem_59_5115
Author(s) : Liu Q , Chen X , Chen W , Yuan X , Su H , Shen J , Xu Y
Ref : Journal of Medicinal Chemistry , 59 :5115 , 2016
PubMedID: 27078579
Gene_locus related to this paper: human-PLA2G7

Title : Association between Ala379Val polymorphism of lipoprotein-associated phospholipase A2 and migraine without aura in Iranian population - Haghdoost_2016_Iran.J.Neurol_15_80
Author(s) : Haghdoost F , Gharzi M , Faez F , Hosseinzadeh E , Tajaddini M , Ra Ei L , Asgari F , Banihashemi M , Masjedi SS , Zandifar A , Haghjooy-Javanmard S
Ref : Iran Journal of Neurology , 15 :80 , 2016
PubMedID: 27326362
Gene_locus related to this paper: human-PLA2G7

Title : Discovery of a Novel Series of Imidazo[1,2-a]pyrimidine Derivatives as Potent and Orally Bioavailable Lipoprotein-Associated Phospholipase A2 Inhibitors - Chen_2015_J.Med.Chem_58_8529
Author(s) : Chen X , Xu W , Wang K , Mo M , Zhang W , Du L , Yuan X , Xu Y , Wang Y , Shen J
Ref : Journal of Medicinal Chemistry , 58 :8529 , 2015
PubMedID: 26479945
Gene_locus related to this paper: human-PLA2G7

Title : Naturally Occurring Missense Mutation in Plasma PAF-AH Among the Japanese Population - Karasawa_2015_Enzymes_38_117
Author(s) : Karasawa K
Ref : Enzymes , 38 :117 , 2015
PubMedID: 26612650
Gene_locus related to this paper: human-PLA2G7

Title : Lipoprotein-associated phospholipase A2 single-nucleotide polymorphisms and cardiovascular events in patients with coronary artery disease - Maiolino_2015_J.Cardiovasc.Med.(Hagerstown)_16_29
Author(s) : Maiolino G , Lenzini L , Pedon L , Cesari M , Seccia TM , Frigo AC , Rossitto G , Caroccia B , Rossi GP
Ref : J Cardiovasc Med (Hagerstown) , 16 :29 , 2015
PubMedID: 24732951
Gene_locus related to this paper: human-PLA2G7

Title : A rationally designed mutant of plasma platelet-activating factor acetylhydrolase hydrolyzes the organophosphorus nerve agent soman - Kirby_2015_Biochim.Biophys.Acta_1854_1809
Author(s) : Kirby SD , Norris J , Sweeney R , Bahnson BJ , Cerasoli DM
Ref : Biochimica & Biophysica Acta , 1854 :1809 , 2015
PubMedID: 26343853
Gene_locus related to this paper: human-PLA2G7

Title : Relationship between plasma phospholipase A2 concentrations and lipoprotein subfractions in patients with stable coronary artery disease - Xu_2015_Clin.Chim.Acta_446_195
Author(s) : Xu RX , Zhang Y , Li XL , Li S , Guo YL , Dong Q , Liu G , Li JJ
Ref : Clinica Chimica Acta , 446 :195 , 2015
PubMedID: 25934512
Gene_locus related to this paper: human-PLA2G7

Title : Nonsynonymous polymorphisms in PLA2G7 gene are associated with the risk of coronary heart disease in a southern Chinese population - Hong_2015_Mamm.Genome_26_191
Author(s) : Hong M , Zhang M , Lu X
Ref : Mamm Genome , 26 :191 , 2015
PubMedID: 25690150
Gene_locus related to this paper: human-PLA2G7

Title : Associations of platelet-activating factor acetylhydrolase (PAF-AH) gene polymorphisms with circulating PAF-AH levels and risk of coronary heart disease or blood stasis syndrome in the Chinese Han population - Zheng_2014_Mol.Biol.Rep_41_7141
Author(s) : Zheng GH , Xiong SQ , Chen HY , Mei LJ , Wang T
Ref : Mol Biol Rep , 41 :7141 , 2014
PubMedID: 25034894
Gene_locus related to this paper: human-PLA2G7

Title : Changes in lipoprotein-Associated phospholipase A2 activity predict coronary events and partly account for the treatment effect of pravastatin: results from the Long-Term Intervention with Pravastatin in Ischemic Disease study - White_2013_J.Am.Heart.Assoc_2_e000360
Author(s) : White HD , Simes J , Stewart RA , Blankenberg S , Barnes EH , Marschner IC , Thompson P , West M , Zeller T , Colquhoun DM , Nestel P , Keech AC , Sullivan DR , Hunt D , Tonkin A
Ref : J Am Heart Assoc , 2 :e000360 , 2013
PubMedID: 24152981
Gene_locus related to this paper: human-PLA2G7

Title : Eight genetic loci associated with variation in lipoprotein-associated phospholipase A2 mass and activity and coronary heart disease: meta-analysis of genome-wide association studies from five community-based studies - Grallert_2012_Eur.Heart.J_33_238
Author(s) : Grallert H , Dupuis J , Bis JC , Dehghan A , Barbalic M , Baumert J , Lu C , Smith NL , Uitterlinden AG , Roberts R , Khuseyinova N , Schnabel RB , Rice KM , Rivadeneira F , Hoogeveen RC , Fontes JD , Meisinger C , Keaney JF, Jr. , Lemaitre R , Aulchenko YS , Vasan RS , Ellis S , Hazen SL , van Duijn CM , Nelson JJ , Marz W , Schunkert H , McPherson RM , Stirnadel-Farrant HA , Psaty BM , Gieger C , Siscovick D , Hofman A , Illig T , Cushman M , Yamamoto JF , Rotter JI , Larson MG , Stewart AF , Boerwinkle E , Witteman JC , Tracy RP , Koenig W , Benjamin EJ , Ballantyne CM
Ref : Eur Heart J , 33 :238 , 2012
PubMedID: 22003152
Gene_locus related to this paper: human-PLA2G7

Title : Sequencing of Lp-PLA2-encoding PLA2G7 gene in 2000 Europeans reveals several rare loss-of-function mutations - Song_2012_Pharmacogenomics.J_12_425
Author(s) : Song K , Nelson MR , Aponte J , Manas ES , Bacanu SA , Yuan X , Kong X , Cardon L , Mooser VE , Whittaker JC , Waterworth DM
Ref : Pharmacogenomics J , 12 :425 , 2012
PubMedID: 21606947
Gene_locus related to this paper: human-PLA2G7

Title : Lipoprotein-associated phospholipase A2 activity predicts cardiovascular events in high risk coronary artery disease patients - Maiolino_2012_PLoS.One_7_e48171
Author(s) : Maiolino G , Pedon L , Cesari M , Frigo AC , Wolfert RL , Barisa M , Pagliani L , Rossitto G , Seccia TM , Zanchetta M , Rossi GP
Ref : PLoS ONE , 7 :e48171 , 2012
PubMedID: 23118945
Gene_locus related to this paper: human-PLA2G7

Title : Lipoprotein-associated phospholipase A2 gene V279F polymorphisms and coronary heart disease: a meta-analysis - Zheng_2011_Mol.Biol.Rep_38_4089
Author(s) : Zheng GH , Chen HY , Xiong SQ , Chu JF
Ref : Mol Biol Rep , 38 :4089 , 2011
PubMedID: 21107710
Gene_locus related to this paper: human-PLA2G7

Title : Carriage of the V279F null allele within the gene encoding Lp-PLA(2) is protective from coronary artery disease in South Korean males - Jang_2011_PLoS.One_6_e18208
Author(s) : Jang Y , Waterworth D , Lee JE , Song K , Kim S , Kim HS , Park KW , Cho HJ , Oh IY , Park JE , Lee BS , Ku HJ , Shin DJ , Lee JH , Jee SH , Han BG , Jang HY , Cho EY , Vallance P , Whittaker J , Cardon L , Mooser V
Ref : PLoS ONE , 6 :e18208 , 2011
PubMedID: 21490708
Gene_locus related to this paper: human-PLA2G7

Title : Association between lipoprotein-associated phospholipase A2 gene polymorphism and coronary artery disease in the Chinese Han population - Li_2011_Ann.Hum.Genet_75_605
Author(s) : Li L , Qi L , Lv N , Gao Q , Cheng Y , Wei Y , Ye J , Yan X , Dang A
Ref : Ann Hum Genet , 75 :605 , 2011
PubMedID: 21834908
Gene_locus related to this paper: human-PLA2G7

Title : Lipoprotein associated phospholipase A(2): role in atherosclerosis and utility as a biomarker for cardiovascular risk - Colley_2011_EPMA.J_2_27
Author(s) : Colley KJ , Wolfert RL , Cobble ME
Ref : EPMA J , 2 :27 , 2011
PubMedID: 21654904
Gene_locus related to this paper: human-PLA2G7

Title : PLA2G7 genotype, lipoprotein-associated phospholipase A2 activity, and coronary heart disease risk in 10 494 cases and 15 624 controls of European Ancestry - Casas_2010_Circulation_121_2284
Author(s) : Casas JP , Ninio E , Panayiotou A , Palmen J , Cooper JA , Ricketts SL , Sofat R , Nicolaides AN , Corsetti JP , Fowkes FG , Tzoulaki I , Kumari M , Brunner EJ , Kivimaki M , Marmot MG , Hoffmann MM , Winkler K , Marz W , Ye S , Stirnadel HA , Boekholdt SM , Khaw KT , Humphries SE , Sandhu MS , Hingorani AD , Talmud PJ
Ref : Circulation , 121 :2284 , 2010
PubMedID: 20479152
Gene_locus related to this paper: human-PLA2G7

Title : Identification of the G994T polymorphism in exon 9 of plasma platelet-activating factor acetylhydrolase gene as a risk factor for polycystic ovary syndrome - Fan_2010_Hum.Reprod_25_1288
Author(s) : Fan P , Liu Hw , Wang XS , Zhang F , Song Q , Li Q , Wu HM , Bai H
Ref : Hum Reprod , 25 :1288 , 2010
PubMedID: 20185515
Gene_locus related to this paper: human-PLA2G7

Title : PLA2G7 gene polymorphisms and coronary heart disease risk: a meta-analysis - Wang_2010_Thromb.Res_126_498
Author(s) : Wang Q , Hao Y , Mo X , Wang L , Lu X , Huang J , Cao J , Li H , Gu D
Ref : Thromb Res , 126 :498 , 2010
PubMedID: 20926117
Gene_locus related to this paper: human-PLA2G7

Title : Lipoprotein-associated phospholipase A2: role in atherosclerosis and utility as a cardiovascular biomarker - Toth_2010_Expert.Rev.Cardiovasc.Ther_8_425
Author(s) : Toth PP , McCullough PA , Wegner MS , Colley KJ
Ref : Expert Rev Cardiovasc Ther , 8 :425 , 2010
PubMedID: 20222820
Gene_locus related to this paper: human-PLA2G7

Title : Genetic variants and haplotypes of lipoprotein associated phospholipase A2 and their influence on cardiovascular disease (The Ludwigshafen Risk and Cardiovascular Health Study) - Hoffmann_2009_J.Thromb.Haemost_7_41
Author(s) : Hoffmann MM , Winkler K , Renner W , Winkelmann BR , Seelhorst U , Wellnitz B , Boehm BO , Marz W
Ref : J Thromb Haemost , 7 :41 , 2009
PubMedID: 18983494
Gene_locus related to this paper: human-PLA2G7

Title : Associations of PLA2G7 gene polymorphisms with plasma lipoprotein-associated phospholipase A2 activity and coronary heart disease in a Chinese Han population: the Beijing atherosclerosis study - Hou_2009_Hum.Genet_125_11
Author(s) : Hou L , Chen S , Yu H , Lu X , Chen J , Wang L , Huang J , Fan Z , Gu D
Ref : Hum Genet , 125 :11 , 2009
PubMedID: 19034521
Gene_locus related to this paper: human-PLA2G7

Title : Inter-individual variability of plasma PAF-acetylhydrolase activity in ARDS patients and PAFAH genotype - Li_2009_J.Clin.Pharm.Ther_34_447
Author(s) : Li S , Stuart L , Zhang Y , Meduri GU , Umberger R , Yates CR
Ref : J Clin Pharm Ther , 34 :447 , 2009
PubMedID: 19583678
Gene_locus related to this paper: human-PLA2G7

Title : Effects of G994T in the Lp-PLA2 gene on the plasma oxidized LDL level and carotid intima-media thickness in Japanese: the Shimane study - Wang_2009_Am.J.Hypertens_22_742
Author(s) : Wang T , Karino K , Yamasaki M , Zhang Y , Masuda J , Yamaguchi S , Shiwaku K , Nabika T
Ref : Am J Hypertens , 22 :742 , 2009
PubMedID: 19373214
Gene_locus related to this paper: human-PLA2G7

Title : Crystal structures of human group-VIIA phospholipase A2 inhibited by organophosphorus nerve agents exhibit non-aged complexes - Samanta_2009_Biochem.Pharmacol_78_420
Author(s) : Samanta U , Kirby SD , Srinivasan P , Cerasoli DM , Bahnson BJ
Ref : Biochemical Pharmacology , 78 :420 , 2009
PubMedID: 19394314
Gene_locus related to this paper: human-PLA2G7

Title : Identification of a domain that mediates association of platelet-activating factor acetylhydrolase with high density lipoprotein - Gardner_2008_J.Biol.Chem_283_17099
Author(s) : Gardner AA , Reichert EC , Topham MK , Stafforini DM
Ref : Journal of Biological Chemistry , 283 :17099 , 2008
PubMedID: 18434304
Gene_locus related to this paper: human-PLA2G7

Title : Comprehensive genetic analysis of the platelet activating factor acetylhydrolase (PLA2G7) gene and cardiovascular disease in case-control and family datasets - Sutton_2008_Hum.Mol.Genet_17_1318
Author(s) : Sutton BS , Crosslin DR , Shah SH , Nelson SC , Bassil A , Hale AB , Haynes C , Goldschmidt-Clermont PJ , Vance JM , Seo D , Kraus WE , Gregory SG , Hauser ER
Ref : Hum Mol Genet , 17 :1318 , 2008
PubMedID: 18204052
Gene_locus related to this paper: human-PLA2G7

Title : Crystal structure of human plasma platelet-activating factor acetylhydrolase: structural implication to lipoprotein binding and catalysis - Samanta_2008_J.Biol.Chem_283_31617
Author(s) : Samanta U , Bahnson BJ
Ref : Journal of Biological Chemistry , 283 :31617 , 2008
PubMedID: 18784071
Gene_locus related to this paper: human-PLA2G7

Title : Inhibition of lipoprotein-associated phospholipase A2 reduces complex coronary atherosclerotic plaque development - Wilensky_2008_Nat.Med_14_1059
Author(s) : Wilensky RL , Shi Y , Mohler ER, 3rd , Hamamdzic D , Burgert ME , Li J , Postle A , Fenning RS , Bollinger JG , Hoffman BE , Pelchovitz DJ , Yang J , Mirabile RC , Webb CL , Zhang L , Zhang P , Gelb MH , Walker MC , Zalewski A , Macphee CH
Ref : Nat Med , 14 :1059 , 2008
PubMedID: 18806801
Gene_locus related to this paper: human-PLA2G7

Title : Comprehensive evaluation of genetic and environmental factors influencing the plasma lipoprotein-associated phospholipase A2 activity in a Japanese population - Zhang_2007_Hypertens.Res_30_403
Author(s) : Zhang SY , Shibata H , Karino K , Wang BY , Kobayashi S , Masuda J , Nabika T
Ref : Hypertens Res , 30 :403 , 2007
PubMedID: 17587752
Gene_locus related to this paper: human-PLA2G7

Title : Lipoprotein-associated phospholipase A2 A379V variant is associated with body composition changes in response to exercise training - Wootton_2007_Nutr.Metab.Cardiovasc.Dis_17_24
Author(s) : Wootton PT , Flavell DM , Montgomery HE , World M , Humphries SE , Talmud PJ
Ref : Nutr Metab Cardiovasc Dis , 17 :24 , 2007
PubMedID: 17174223
Gene_locus related to this paper: human-PLA2G7

Title : Collaborative meta-analysis of individual participant data from observational studies of Lp-PLA2 and cardiovascular diseases - Ballantyne_2007_Eur.J.Cardiovasc.Prev.Rehabil_14_3
Author(s) : Ballantyne C , Cushman M , Psaty B , Furberg C , Khaw KT , Sandhu M , Oldgren J , Rossi GP , Maiolino G , Cesari M , Lenzini L , James SK , Rimm E , Collins R , Anderson J , Koenig W , Brenner H , Rothenbacher D , Berglund G , Persson M , Berger P , Brilakis E , McConnell JP , Sacco R , Elkind M , Talmud P , Cannon CP , Packard C , Barrett-Connor E , Hofman A , Kardys I , Witteman JC , Criqui M , Corsetti JP , Rainwater DL , Moss AJ , Robins S , Bloomfield H , Collins D , Wassertheil-Smoller S , Ridker P , Danesh J , Gu D , Nelson JJ , Thompson S , Zalewski A , Zariffa N , Di Angelantonio E , Kaptoge S , Thompson A , Walker M , Watson S , Wood A
Ref : Eur J Cardiovasc Prev Rehabil , 14 :3 , 2007
PubMedID: 17301621
Gene_locus related to this paper: human-PLA2G7

Title : The Val279Phe variant of the lipoprotein-associated phospholipase A2 gene is associated with catalytic activities and cardiovascular disease in Korean men - Jang_2006_J.Clin.Endocrinol.Metab_91_3521
Author(s) : Jang Y , Kim OY , Koh SJ , Chae JS , Ko YG , Kim JY , Cho H , Jeong TS , Lee WS , Ordovas JM , Lee JH
Ref : J Clinical Endocrinology Metab , 91 :3521 , 2006
PubMedID: 16787988
Gene_locus related to this paper: human-PLA2G7

Title : Platelet-activating factor-acetylhydrolase A379V (exon 11) gene polymorphism is an independent and functional risk factor for premature myocardial infarction - Liu_2006_J.Thromb.Haemost_4_1023
Author(s) : Liu PY , Li YH , Wu HL , Chao TH , Tsai LM , Lin LJ , Shi GY , Chen JH
Ref : J Thromb Haemost , 4 :1023 , 2006
PubMedID: 16689754
Gene_locus related to this paper: human-PLA2G7

Title : Association of platelet-activating factor acetylhydrolase gene polymorphism with premature coronary artery disease in Turkish patients - Sekuri_2006_Anadolu.Kardiyol.Derg_6_132
Author(s) : Sekuri C , Cam FS , Tengiz I , Ercan E , Bayturan O , Berdeli A
Ref : Anadolu Kardiyol Derg , 6 :132 , 2006
PubMedID: 16766276
Gene_locus related to this paper: human-PLA2G7

Title : Vasospastic angina and microvascular angina are differentially influenced by PON1 A632G polymorphism in the Japanese - Mashiba_2005_Circ.J_69_1466
Author(s) : Mashiba J , Koike G , Kamiunten H , Ikeda M , Sunagawa K
Ref : Circ J , 69 :1466 , 2005
PubMedID: 16308493
Gene_locus related to this paper: human-PLA2G7

Title : Functional impairment of two novel mutations detected in lipoprotein-associated phospholipase A2 (Lp-PLA2) deficiency patients - Ishihara_2004_J.Hum.Genet_49_302
Author(s) : Ishihara M , Iwasaki T , Nagano M , Ishii J , Takano M , Kujiraoka T , Tsuji M , Hattori H , Emi M
Ref : J Hum Genet , 49 :302 , 2004
PubMedID: 15148590
Gene_locus related to this paper: human-PLA2G7

Title : Platelet-activating factor-acetylhydrolase and PAF-receptor gene haplotypes in relation to future cardiovascular event in patients with coronary artery disease - Ninio_2004_Hum.Mol.Genet_13_1341
Author(s) : Ninio E , Tregouet D , Carrier JL , Stengel D , Bickel C , Perret C , Rupprecht HJ , Cambien F , Blankenberg S , Tiret L
Ref : Hum Mol Genet , 13 :1341 , 2004
PubMedID: 15115767
Gene_locus related to this paper: human-PLA2G7

Title : Association between the Ala379Val variant of the lipoprotein associated phospholipase A2 and risk of myocardial infarction in the north and south of Europe - Abuzeid_2003_Atherosclerosis_168_283
Author(s) : Abuzeid AM , Hawe E , Humphries SE , Talmud PJ
Ref : Atherosclerosis , 168 :283 , 2003
PubMedID: 12801611
Gene_locus related to this paper: human-PLA2G7

Title : Association of plasma PAF acetylhydrolase gene polymorphism with IMT of carotid arteries in Japanese type 2 diabetic patients - Yamamoto_2003_Diabetes.Res.Clin.Pract_59_219
Author(s) : Yamamoto I , Fujitsu J , Nohnen S , Igarashi T , Motomura T , Inaba M , Tsubakimori S , Azuma J
Ref : Diabetes Res Clin Pract , 59 :219 , 2003
PubMedID: 12590019
Gene_locus related to this paper: human-PLA2G7

Title : Evidence for the existence of the PAF acetylhydrolase mutation (Val279Phe) in non-Japanese populations: a preliminary study in Turkey, Azerbaijan, and Kyrgyzstan - Balta_2001_Thromb.Res_101_231
Author(s) : Balta G , Gurgey A , Kudayarov DK , Tunc B , Altay C
Ref : Thromb Res , 101 :231 , 2001
PubMedID: 11248283
Gene_locus related to this paper: human-PLA2G7

Title : A simple assay for a human serum phospholipase A2 that is associated with high-density lipoproteins - Petrovic_2001_J.Lipid.Res_42_1706
Author(s) : Petrovic N , Grove C , Langton PE , Misso NL , Thompson PJ
Ref : J Lipid Res , 42 :1706 , 2001
PubMedID: 11590228
Gene_locus related to this paper: human-PLA2G7

Title : Platelet-activating factor acetylhydrolase gene mutation in Japanese children with Escherichia coli O157-associated hemolytic uremic syndrome - Xu_2000_Am.J.Kidney.Dis_36_42
Author(s) : Xu H , Iijima K , Shirakawa T , Shiozawa S , Miwa M , Yamaoka K , Kawamura N , Nakamura H , Yoshikawa N
Ref : Am J Kidney Dis , 36 :42 , 2000
PubMedID: 10873870
Gene_locus related to this paper: human-PLA2G7

Title : The Ile198Thr and Ala379Val variants of plasmatic PAF-acetylhydrolase impair catalytical activities and are associated with atopy and asthma - Kruse_2000_Am.J.Hum.Genet_66_1522
Author(s) : Kruse S , Mao XQ , Heinzmann A , Blattmann S , Roberts MH , Braun S , Gao PS , Forster J , Kuehr J , Hopkin JM , Shirakawa T , Deichmann KA
Ref : American Journal of Human Genetics , 66 :1522 , 2000
PubMedID: 10733466
Gene_locus related to this paper: human-PLA2G7

Title : Lipoprotein-associated phospholipase A2 as an independent predictor of coronary heart disease. West of Scotland Coronary Prevention Study Group - Packard_2000_N.Engl.J.Med_343_1148
Author(s) : Packard CJ , O'Reilly DS , Caslake MJ , McMahon AD , Ford I , Cooney J , Macphee CH , Suckling KE , Krishna M , Wilkinson FE , Rumley A , Lowe GD
Ref : N Engl J Med , 343 :1148 , 2000
PubMedID: 11036120
Gene_locus related to this paper: human-PLA2G7

Title : Correlations between plasma platelet-activating factor acetylhydrolase (PAF-AH) activity and PAF-AH genotype, age, and atherosclerosis in a Japanese population - Yamada_2000_Atherosclerosis_150_209
Author(s) : Yamada Y , Yoshida H , Ichihara S , Imaizumi T , Satoh K , Yokota M
Ref : Atherosclerosis , 150 :209 , 2000
PubMedID: 10781653
Gene_locus related to this paper: human-PLA2G7

Title : Role of platelet-activating factor acetylhydrolase gene mutation in Japanese childhood IgA nephropathy - Tanaka_1999_Am.J.Kidney.Dis_34_289
Author(s) : Tanaka R , Iijima K , Xu H , Inoue Y , Murakami R , Shirakawa T , Nishiyama K , Miwa M , Shiozawa S , Nakamura H , Yoshikawa N
Ref : Am J Kidney Dis , 34 :289 , 1999
PubMedID: 10430976
Gene_locus related to this paper: human-PLA2G7

Title : A genome-wide search for linkage to asthma. German Asthma Genetics Group - Wjst_1999_Genomics_58_1
Author(s) : Wjst M , Fischer G , Immervoll T , Jung M , Saar K , Rueschendorf F , Reis A , Ulbrecht M , Gomolka M , Weiss EH , Jaeger L , Nickel R , Richter K , Kjellman NI , Griese M , von Berg A , Gappa M , Riedel F , Boehle M , van Koningsbruggen S , Schoberth P , Szczepanski R , Dorsch W , Silbermann M , Loesgen S , Scholz M , Bickeboller H , Wichmann HE
Ref : Genomics , 58 :1 , 1999
PubMedID: 10333435
Gene_locus related to this paper: human-PLA2G7

Title : Deficiency of platelet-activating factor acetylhydrolase is a severity factor for asthma - Stafforini_1999_J.Clin.Invest_103_989
Author(s) : Stafforini DM , Numao T , Tsodikov A , Vaitkus D , Fukuda T , Watanabe N , Fueki N , McIntyre TM , Zimmerman GA , Makino S , Prescott SM
Ref : J Clinical Investigation , 103 :989 , 1999
PubMedID: 10194471
Gene_locus related to this paper: human-PLA2G7

Title : Genome-wide search for asthma susceptibility loci in a founder population. The Collaborative Study on the Genetics of Asthma - Ober_1998_Hum.Mol.Genet_7_1393
Author(s) : Ober C , Cox NJ , Abney M , Di Rienzo A , Lander ES , Changyaleket B , Gidley H , Kurtz B , Lee J , Nance M , Pettersson A , Prescott J , Richardson A , Schlenker E , Summerhill E , Willadsen S , Parry R
Ref : Hum Mol Genet , 7 :1393 , 1998
PubMedID: 9700192
Gene_locus related to this paper: human-PLA2G7

Title : Platelet-activating factor acetylhydrolase gene mutation in Japanese nephrotic children - Xu_1998_Kidney.Int_54_1867
Author(s) : Xu H , Iijima K , Shiozawa S , Tanaka SS , Inoue Y , Shirakawa T , Nishiyama K , Miwa M , Nakamura H , Yoshikawa N
Ref : Kidney Int , 54 :1867 , 1998
PubMedID: 9853251
Gene_locus related to this paper: human-PLA2G7

Title : Identification of the G994--> T missense in exon 9 of the plasma platelet-activating factor acetylhydrolase gene as an independent risk factor for coronary artery disease in Japanese men - Yamada_1998_Metabolism_47_177
Author(s) : Yamada Y , Ichihara S , Fujimura T , Yokota M
Ref : Metabolism , 47 :177 , 1998
PubMedID: 9472966
Gene_locus related to this paper: human-PLA2G7

Title : A mutation in plasma platelet-activating factor acetylhydrolase (Val279Phe) is a genetic risk factor for cerebral hemorrhage but not for hypertension - Yoshida_1998_Thromb.Haemost_80_372
Author(s) : Yoshida H , Imaizumi T , Fujimoto K , Itaya H , Hiramoto M , Yoshimizu N , Fukushi K , Satoh K
Ref : Thromb Haemost , 80 :372 , 1998
PubMedID: 9759612
Gene_locus related to this paper: human-PLA2G7

Title : Systematic screening of the LDL-PLA2 gene for polymorphic variants and case-control analysis in schizophrenia - Bell_1997_Biochem.Biophys.Res.Commun_241_630
Author(s) : Bell R , Collier DA , Rice SQ , Roberts GW , Macphee CH , Kerwin RW , Price J , Gloger IS
Ref : Biochemical & Biophysical Research Communications , 241 :630 , 1997
PubMedID: 9434759
Gene_locus related to this paper: human-PLA2G7

Title : Loss of activity of plasma platelet-activating factor acetylhydrolase due to a novel Gln281-->Arg mutation - Yamada_1997_Biochem.Biophys.Res.Commun_236_772
Author(s) : Yamada Y , Yokota M
Ref : Biochemical & Biophysical Research Communications , 236 :772 , 1997
PubMedID: 9245731
Gene_locus related to this paper: human-PLA2G7

Title : A mutation in plasma platelet-activating factor acetylhydrolase (Val279-->\;Phe) is a genetic risk factor for stroke - Hiramoto_1997_Stroke_28_2417
Author(s) : Hiramoto M , Yoshida H , Imaizumi T , Yoshimizu N , Satoh K
Ref : Stroke , 28 :2417 , 1997
PubMedID: 9412624
Gene_locus related to this paper: human-PLA2G7

Title : Genetics reveals importance of platelet activating factor in asthma and possibly other inflammatory states -
Author(s) : Nadel JA
Ref : J Clinical Investigation , 97 :2689 , 1996
PubMedID: 8675676
Gene_locus related to this paper: human-PLA2G7

Title : Interaction of platelet-activating factor with rat hepatocytes: uptake, translocation, metabolism, and effects on PAF-acetylhydrolase secretion and protein tyrosine phosphorylation - Svetlov_1996_Arch.Biochem.Biophys_327_113
Author(s) : Svetlov SI , Howard KM , Miwa M , Flickinger BD , Olson MS
Ref : Archives of Biochemistry & Biophysics , 327 :113 , 1996
PubMedID: 8615681
Gene_locus related to this paper: human-PLA2G7

Title : Purification, properties, sequencing, and cloning of a lipoprotein-associated, serine-dependent phospholipase involved in the oxidative modification of low-density lipoproteins - Tew_1996_Arterioscler.Thromb.Vasc.Biol_16_591
Author(s) : Tew DG , Southan C , Rice SQ , Lawrence MP , Li H , Boyd HF , Moores K , Gloger IS , Macphee CH
Ref : Arterioscler Thromb Vasc Biol , 16 :591 , 1996
PubMedID: 8624782
Gene_locus related to this paper: human-PLA2G7

Title : Platelet-activating factor acetylhydrolase deficiency. A missense mutation near the active site of an anti-inflammatory phospholipase - Stafforini_1996_J.Clin.Invest_97_2784
Author(s) : Stafforini DM , Satoh K , Atkinson DL , Tjoelker LW , Eberhardt C , Yoshida H , Imaizumi T , Takamatsu S , Zimmerman GA , McIntyre TM , Gray PW , Prescott SM
Ref : J Clinical Investigation , 97 :2784 , 1996
PubMedID: 8675689
Gene_locus related to this paper: human-PLA2G7

Title : Anti-inflammatory properties of a platelet-activating factor acetylhydrolase - Tjoelker_1995_Nature_374_549
Author(s) : Tjoelker LW , Wilder C , Eberhardt C , Stafforini DM
Ref : Nature , 374 :549 , 1995
PubMedID: 7700381
Gene_locus related to this paper: bovin-pafa , canfa-pafa , chick-pafa , human-PLA2G7 , mouse-pafa

Title : Presence of platelet-activating factor-acetylhydrolase in milk - Furukawa_1993_J.Lipid.Res_34_1603
Author(s) : Furukawa M , Narahara H , Yasuda K , Johnston JM
Ref : J Lipid Res , 34 :1603 , 1993
PubMedID: 8228643
Gene_locus related to this paper: human-PLA2G7

Title : Novel General Approach for the Assay and Inhibition of Hydrolytic Enzymes Utilizing Suicide-Inhibitory Bifunctionally Linked Substrates (SIBLINKS): Exemplified by a Phospholipase A2 Assay - Washburn_1990_J.Am.Chem.Soc_112_2040
Author(s) : Washburn WN , Dennis
Ref : Journal of the American Chemical Society , 112 :2040 , 1990
PubMedID:
Gene_locus related to this paper: human-PLA2G7

Title : Characterization of serum platelet-activating factor (PAF) acetylhydrolase. Correlation between deficiency of serum PAF acetylhydrolase and respiratory symptoms in asthmatic children - Miwa_1988_J.Clin.Invest_82_1983
Author(s) : Miwa M , Miyake T , Yamanaka T , Sugatani J , Suzuki Y , Sakata S , Araki Y , Matsumoto M
Ref : J Clinical Investigation , 82 :1983 , 1988
PubMedID: 3198761
Gene_locus related to this paper: human-PLA2G7