Benes_1976_Vet.Med_21_343

Per os intoxication of sheep with O-ethyl S-(2-dimethylaminoethyl)methyl phosphonium thioate (EDMM) in the dose of 0.209 mg per kg of live weight, that means p.o. LD50 (2 h), can be therapeutically mastered by means of an antidotal mixture of the reactivator of cholinesterase (trimedoxim) and of the cholinolytic (atropine), which is commercially available in the SPOFA preparation TMB-4(Trimedoxime) compos. for human purposes, if the effective dose of the reactivator was 10.0 mg per kg of live weight and if it was applied intravenously, and if the dose of the cholinolytic consisted, per 1 kg of live weight, of 0.08 mm. The antidotal mixture was applied, when the degree of the muscarinic and nicotinic symptoms and the corresponding degree of the inhibition of erythrocytary and plasmatic cholinesterase were on such a level which, according to the classification criteria, we consider a severe grade of intoxication with a dubious diagnosis.