Bodnaryk_1977_Can.J.Biochem_55_534

Reference

Title : Correlation between organophosphate poisoning, acetylcholinesterase inhibition, and increased cyclic GMP levels in malathion-treated insects - Bodnaryk_1977_Can.J.Biochem_55_534
Author(s) : Bodnaryk RP
Ref : Canadian Journal of Biochemistry , 55 :534 , 1977
Abstract : Organophosphate poisoning with malathion caused large increases (up to 125 and 440%, respectively) in the level of cyclic GMP in larvae of Mamestra configurata Wlk. and in the fly Sarcophaga bullata Parker. Cyclic AMP was little affected. The malathion-induced increase in cyclic GMP was time and dose dependent. Time-course studies with the head and thorax of S. bullata demonstrated that the increase in cyclic GMP level occurred precipitously after a lag period of about 1 h, during which time the activity of acetylcholinesterase (EC 3.1.1.7) was progressively inhibited. The abrupt increase in cyclic GMP began when acetylcholinesterase activity had been inhibited to a sufficient extent to permit accumulation of acetylcholine. It is suggested that the accumulation of acetylcholine in the malathion-poisoned insects caused cyclic GMP levels to rise. Cyclic GMP may have a role in cholinergic transmission in normally functioning insect neural tissue. Increased levels of cyclic GMP induced by organophosphate and organocholorine (Bodnaryk, R. P. (1976) Can. J. Biochem. 54, 957-962) insecticides appear to be a vital and previously unrecognized biochemical lesion in insects poisoned by these compounds.
ESTHER : Bodnaryk_1977_Can.J.Biochem_55_534
PubMedSearch : Bodnaryk_1977_Can.J.Biochem_55_534
PubMedID: 195684

Related information

Inhibitor Malathion

Citations formats

Bodnaryk RP (1977)
Correlation between organophosphate poisoning, acetylcholinesterase inhibition, and increased cyclic GMP levels in malathion-treated insects
Canadian Journal of Biochemistry 55 :534

Bodnaryk RP (1977)
Canadian Journal of Biochemistry 55 :534