Bosch_1992_Eur.J.Pharmacol_222_163

Reference

Title : Effects of velnacrine, tacrine and physostigmine on tetanic twitch responses at the rat neuromuscular junction - Bosch_1992_Eur.J.Pharmacol_222_163
Author(s) : Bosch F , Morales M , Badia A , Banos JE
Ref : European Journal of Pharmacology , 222 :163 , 1992
Abstract :

The effects of velnacrine (1-hydroxytacrine), tacrine and physostigmine on indirectly elicited twitch at low and high stimulation frequencies were analyzed in the rat phrenic hemidiaphragm preparation. At 0.2 Hz, velnacrine and physostigmine behaved in a similar manner, the latter showing a higher potentiating effect. This potentiation was observed at 3-100 microM velnacrine, whereas a slight depression appeared at higher concentrations. When tetanic responses were studied, the drug concentrations needed to depress tetanic tension and tetanic fade were quite different in the case of velnacrine (depression of tetanic tension from 1 microM and tetanic fade from 170 microM), whereas physostigmine and tacrine were able to affect these parameters at very similar concentrations. The results suggest that some effects of velnacrine could differ from those of tacrine in spite of the chemical similarity.

PubMedSearch : Bosch_1992_Eur.J.Pharmacol_222_163
PubMedID: 1468493

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Citations formats

Bosch F, Morales M, Badia A, Banos JE (1992)
Effects of velnacrine, tacrine and physostigmine on tetanic twitch responses at the rat neuromuscular junction
European Journal of Pharmacology 222 :163

Bosch F, Morales M, Badia A, Banos JE (1992)
European Journal of Pharmacology 222 :163