| Title : Huprine X Attenuates The Neurotoxicity Induced by Kainic Acid, Especially Brain Inflammation - Relat_2018_Basic.Clin.Pharmacol.Toxicol_122_94 |
| Author(s) : Relat J , Perez B , Camps P , Munoz-Torrero D , Badia A , Victoria Clos M |
| Ref : Basic Clin Pharmacol Toxicol , 122 :94 , 2018 |
| Abstract : |
| PubMedSearch : Relat_2018_Basic.Clin.Pharmacol.Toxicol_122_94 |
| PubMedID: 28724203 |
| Title : Neuroprotective Effects of the Multitarget Agent AVCRI104P3 in Brain of Middle-Aged Mice - Relat_2018_Int.J.Mol.Sci_19_ |
| Author(s) : Relat J , Come J , Perez B , Camps P , Munoz-Torrero D , Badia A , Gimenez-Llort L , Clos MV |
| Ref : Int J Mol Sci , 19 : , 2018 |
| Abstract : |
| PubMedSearch : Relat_2018_Int.J.Mol.Sci_19_ |
| PubMedID: 30181440 |
| Title : Behavioural effects of novel multitarget anticholinesterasic derivatives in Alzheimer's disease - Gimenez-Llort_2017_Behav.Pharmacol_28_124 |
| Author(s) : Gimenez-Llort L , Ratia M , Perez B , Camps P , Munoz-Torrero D , Badia A , Clos MV |
| Ref : Behav Pharmacol , 28 :124 , 2017 |
| Abstract : |
| PubMedSearch : Gimenez-Llort_2017_Behav.Pharmacol_28_124 |
| PubMedID: 28125507 |
| Title : AVCRI104P3, a novel multitarget compound with cognition-enhancing and anxiolytic activities: Studies in cognitively poor middle-aged mice - Gimenez-Llort_2015_Behav.Brain.Res_286_97 |
| Author(s) : Gimenez-Llort L , Ratia M , Perez B , Camps P , Munoz-Torrero D , Badia A , Clos MV |
| Ref : Behavioural Brain Research , 286 :97 , 2015 |
| Abstract : |
| PubMedSearch : Gimenez-Llort_2015_Behav.Brain.Res_286_97 |
| PubMedID: 25732954 |
| Title : Undifferentiated and Differentiated PC12 Cells Protected by Huprines Against Injury Induced by Hydrogen Peroxide - Pera_2013_PLoS.One_8_e74344 |
| Author(s) : Pera M , Camps P , Munoz-Torrero D , Perez B , Badia A , Clos Guillen MV |
| Ref : PLoS ONE , 8 :e74344 , 2013 |
| Abstract : |
| PubMedSearch : Pera_2013_PLoS.One_8_e74344 |
| PubMedID: 24086337 |
| Title : Huprine X and Huperzine A Improve Cognition and Regulate Some Neurochemical Processes Related with Alzheimer's Disease in Triple Transgenic Mice (3xTg-AD) - Ratia_2013_Neurodegener.Dis_11_129 |
| Author(s) : Ratia M , Gimenez-Llort L , Camps P , Munoz-Torrero D , Perez B , Clos MV , Badia A |
| Ref : Neurodegener Dis , 11 :129 , 2013 |
| Abstract : |
| PubMedSearch : Ratia_2013_Neurodegener.Dis_11_129 |
| PubMedID: 22626981 |
| Title : Huprine-tacrine heterodimers as anti-amyloidogenic compounds of potential interest against Alzheimer's and prion diseases - Galdeano_2012_J.Med.Chem_55_661 |
| Author(s) : Galdeano C , Viayna E , Sola I , Formosa X , Camps P , Badia A , Clos MV , Relat J , Ratia M , Bartolini M , Mancini F , Andrisano V , Salmona M , Minguillon C , Gonzalez-Munoz GC , Rodriguez-Franco MI , Bidon-Chanal A , Luque FJ , Munoz-Torrero D |
| Ref : Journal of Medicinal Chemistry , 55 :661 , 2012 |
| Abstract : |
| PubMedSearch : Galdeano_2012_J.Med.Chem_55_661 |
| PubMedID: 22185619 |
| Title : Expanding the multipotent profile of huprine-tacrine heterodimers as disease-modifying anti-Alzheimer agents - Munoz-Torrero_2012_Neurodegener.Dis_10_96 |
| Author(s) : Munoz-Torrero D , Pera M , Relat J , Ratia M , Galdeano C , Viayna E , Sola I , Formosa X , Camps P , Badia A , Clos MV |
| Ref : Neurodegener Dis , 10 :96 , 2012 |
| Abstract : |
| PubMedSearch : Munoz-Torrero_2012_Neurodegener.Dis_10_96 |
| PubMedID: 22236498 |
| Title : Tacrine-based dual binding site acetylcholinesterase inhibitors as potential disease-modifying anti-Alzheimer drug candidates - Camps_2010_Chem.Biol.Interact_187_411 |
| Author(s) : Camps P , Formosa X , Galdeano C , Gomez T , Munoz-Torrero D , Ramirez L , Viayna E , Gomez E , Isambert N , Lavilla R , Badia A , Clos MV , Bartolini M , Mancini F , Andrisano V , Bidon-Chanal A , Huertas O , Dafni T , Luque FJ |
| Ref : Chemico-Biological Interactions , 187 :411 , 2010 |
| Abstract : |
| PubMedSearch : Camps_2010_Chem.Biol.Interact_187_411 |
| PubMedID: 20167211 |
| Title : Effect of huprine X on beta-amyloid, synaptophysin and alpha7 neuronal nicotinic acetylcholine receptors in the brain of 3xTg-AD and APPswe transgenic mice - Hedberg_2010_Neurodegener.Dis_7_379 |
| Author(s) : Hedberg MM , Clos MV , Ratia M , Gonzalez D , Lithner CU , Camps P , Munoz-Torrero D , Badia A , Gimenez-Llort L , Nordberg A |
| Ref : Neurodegener Dis , 7 :379 , 2010 |
| Abstract : |
| PubMedSearch : Hedberg_2010_Neurodegener.Dis_7_379 |
| PubMedID: 20689242 |
| Title : Novel huprine derivatives with inhibitory activity toward beta-amyloid aggregation and formation as disease-modifying anti-Alzheimer drug candidates - Viayna_2010_ChemMedChem_5_1855 |
| Author(s) : Viayna E , Gomez T , Galdeano C , Ramirez L , Ratia M , Badia A , Clos MV , Verdaguer E , Junyent F , Camins A , Pallas M , Bartolini M , Mancini F , Andrisano V , Arce MP , Rodriguez-Franco MI , Bidon-Chanal A , Luque FJ , Camps P , Munoz-Torrero D |
| Ref : ChemMedChem , 5 :1855 , 2010 |
| Abstract : |
| PubMedSearch : Viayna_2010_ChemMedChem_5_1855 |
| PubMedID: 20859987 |
| Title : Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds - Camps_2009_J.Med.Chem_52_5365 |
| Author(s) : Camps P , Formosa X , Galdeano C , Munoz-Torrero D , Ramirez L , Gomez E , Isambert N , Lavilla R , Badia A , Clos MV , Bartolini M , Mancini F , Andrisano V , Arce MP , Rodriguez-Franco MI , Huertas O , Dafni T , Luque FJ |
| Ref : Journal of Medicinal Chemistry , 52 :5365 , 2009 |
| Abstract : |
| PubMedSearch : Camps_2009_J.Med.Chem_52_5365 |
| PubMedID: 19663388 |
| Title : Acetylcholinesterase as an amyloid enhancing factor in PrP82-146 aggregation process - Pera_2009_Mol.Cell.Neurosci_40_217 |
| Author(s) : Pera M , Martinez-Otero A , Colombo L , Salmona M , Ruiz-Molina D , Badia A , Clos MV |
| Ref : Molecular & Cellular Neurosciences , 40 :217 , 2009 |
| Abstract : |
| PubMedSearch : Pera_2009_Mol.Cell.Neurosci_40_217 |
| PubMedID: 19038345 |
| Title : Novel donepezil-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation - Camps_2008_J.Med.Chem_51_3588 |
| Author(s) : Camps P , Formosa X , Galdeano C , Gomez T , Munoz-Torrero D , Scarpellini M , Viayna E , Badia A , Clos MV , Camins A , Pallas M , Bartolini M , Mancini F , Andrisano V , Estelrich J , Lizondo M , Bidon-Chanal A , Luque FJ |
| Ref : Journal of Medicinal Chemistry , 51 :3588 , 2008 |
| Abstract : |
| PubMedSearch : Camps_2008_J.Med.Chem_51_3588 |
| PubMedID: 18517184 |
| Title : Acetylcholinesterase triggers the aggregation of PrP 106-126 - Pera_2006_Biochem.Biophys.Res.Commun_346_89 |
| Author(s) : Pera M , Roman S , Ratia M , Camps P , Munoz-Torrero D , Colombo L , Manzoni C , Salmona M , Badia A , Clos MV |
| Ref : Biochemical & Biophysical Research Communications , 346 :89 , 2006 |
| Abstract : |
| PubMedSearch : Pera_2006_Biochem.Biophys.Res.Commun_346_89 |
| PubMedID: 16750169 |
| Title : Binding of 13-amidohuprines to acetylcholinesterase: exploring the ligand-induced conformational change of the gly117-gly118 peptide bond in the oxyanion hole - Camps_2006_J.Med.Chem_49_6833 |
| Author(s) : Camps P , Gomez E , Munoz-Torrero D , Badia A , Clos MV , Curutchet C , Munoz-Muriedas J , Luque FJ |
| Ref : Journal of Medicinal Chemistry , 49 :6833 , 2006 |
| Abstract : |
| PubMedSearch : Camps_2006_J.Med.Chem_49_6833 |
| PubMedID: 17154513 |
| Title : Effect of acetylcholinesterase inhibitors on AChE-induced PrP106-126 aggregation - Clos_2006_J.Mol.Neurosci_30_89 |
| Author(s) : Clos MV , Pera M , Ratia M , Roman S , Camps P , Munoz-Torrero D , Colombo L , Salmona M , Badia A |
| Ref : Journal of Molecular Neuroscience , 30 :89 , 2006 |
| Abstract : |
| PubMedSearch : Clos_2006_J.Mol.Neurosci_30_89 |
| PubMedID: 17192641 |
| Title : Synthesis and pharmacological evaluation of huprine-tacrine heterodimers: subnanomolar dual binding site acetylcholinesterase inhibitors - Camps_2005_J.Med.Chem_48_1701 |
| Author(s) : Camps P , Formosa X , Munoz-Torrero D , Petrignet J , Badia A , Clos MV |
| Ref : Journal of Medicinal Chemistry , 48 :1701 , 2005 |
| Abstract : |
| PubMedSearch : Camps_2005_J.Med.Chem_48_1701 |
| PubMedID: 15771413 |
| Title : Nicotinic-receptor potentiator drugs, huprine X and galantamine, increase ACh release by blocking AChE activity but not acting on nicotinic receptors - Roman_2005_Brain.Res_1061_73 |
| Author(s) : Roman S , Badia A , Camps P , Munoz-Torrero D , Clos MV |
| Ref : Brain Research , 1061 :73 , 2005 |
| Abstract : |
| PubMedSearch : Roman_2005_Brain.Res_1061_73 |
| PubMedID: 16248990 |
| Title : Potentiation effects of (+\/-)huprine X, a new acetylcholinesterase inhibitor, on nicotinic receptors in rat cortical synaptosomes - Roman_2004_Neuropharmacol_46_95 |
| Author(s) : Roman S , Badia A , Camps P , Clos MV |
| Ref : Neuropharmacology , 46 :95 , 2004 |
| Abstract : |
| PubMedSearch : Roman_2004_Neuropharmacol_46_95 |
| PubMedID: 14654101 |
| Title : Characterisation of the anticholinesterase activity of two new tacrine-huperzine A hybrids - Alcala_2003_Neuropharmacol_44_749 |
| Author(s) : Alcala Mdel M , Vivas NM , Hospital S , Camps P , Munoz-Torrero D , Badia A |
| Ref : Neuropharmacology , 44 :749 , 2003 |
| Abstract : |
| PubMedSearch : Alcala_2003_Neuropharmacol_44_749 |
| PubMedID: 12681373 |
| Title : Synthesis and Acetylcholinesterase\/Butyrylcholinesterase Inhibition Activity of 4-Amino-2, 3-diaryl-5, 6, 7, 8-tetrahydrofuro(and thieno)[2, 3-b]-quinolines, and 4-Amino-5, 6, 7, 8, 9-pentahydro-2, 3-diphenylcyclohepta[e]furo(and thieno)-[2, 3-b]pyridines - Marco_2002_Arch.Pharm.(Weinheim)_335_347 |
| Author(s) : Marco JL , de los Rios C , Carreiras MC , Banos JE , Badia A , Vivas NM |
| Ref : Arch Pharm (Weinheim) , 335 :347 , 2002 |
| Abstract : |
| PubMedSearch : Marco_2002_Arch.Pharm.(Weinheim)_335_347 |
| PubMedID: 12207285 |
| Title : Interaction of a new potent anticholinesterasic compound (+\/-)huprine X with muscarinic receptors in rat brain - Roman_2002_Neurosci.Lett_325_103 |
| Author(s) : Roman S , Vivas NM , Badia A , Clos MV |
| Ref : Neuroscience Letters , 325 :103 , 2002 |
| Abstract : |
| PubMedSearch : Roman_2002_Neurosci.Lett_325_103 |
| PubMedID: 12044632 |
| Title : Synthesis and acetylcholinesterase\/butyrylcholinesterase inhibition activity of new tacrine-like analogues - Marco_2001_Bioorg.Med.Chem_9_727 |
| Author(s) : Marco JL , de los Rios C , Carreiras MC , Banos JE , Badia A , Vivas NM |
| Ref : Bioorganic & Medicinal Chemistry , 9 :727 , 2001 |
| Abstract : |
| PubMedSearch : Marco_2001_Bioorg.Med.Chem_9_727 |
| PubMedID: 11310608 |
| Title : Synthesis, in Vitro Pharmacology, and Molecular Modeling of syn-Huprines as Acetylcholinesterase Inhibitors - Camps_2001_J.Med.Chem_44_4733 |
| Author(s) : Camps P , Gomez E , Munoz-Torrero D , Badia A , Vivas NM , Barril X , Orozco M , Luque FJ |
| Ref : Journal of Medicinal Chemistry , 44 :4733 , 2001 |
| Abstract : |
| PubMedSearch : Camps_2001_J.Med.Chem_44_4733 |
| PubMedID: 11741490 |
| Title : The pharmacology of novel acetylcholinesterase inhibitors, (+\/-)- huprines Y and X, on the Torpedo electric organ - Ros_2001_Eur.J.Pharmacol_421_77 |
| Author(s) : Ros E , Aleu J , Gomez de Aranda I , Munoz-Torrero D , Camps P , Badia A , Marsal J , Solsona C |
| Ref : European Journal of Pharmacology , 421 :77 , 2001 |
| Abstract : |
| PubMedSearch : Ros_2001_Eur.J.Pharmacol_421_77 |
| PubMedID: 11399262 |
| Title : N-Benzylpiperidine derivatives of 1,2,4-thiadiazolidinone as new acetylcholinesterase inhibitors - Martinez_2000_Eur.J.Med.Chem_35_913 |
| Author(s) : Martinez A , Fernandez E , Castro A , Conde S , Rodriguez-Franco I , Banos JE , Badia A |
| Ref : Eur Journal of Medicinal Chemistry , 35 :913 , 2000 |
| Abstract : |
| PubMedSearch : Martinez_2000_Eur.J.Med.Chem_35_913 |
| PubMedID: 11121617 |
| Title : Synthesis of new N-(4-pyridyl)-1-aminopyrazoles and their muscarinic and adrenergic properties - Rodriguez-Franco_2000_Arch.Pharm.(Weinheim)_333_118 |
| Author(s) : Rodriguez-Franco MI , Dorronsoro I , Martinez A , Perez C , Badia A , Banos JE |
| Ref : Arch Pharm (Weinheim) , 333 :118 , 2000 |
| Abstract : |
| PubMedSearch : Rodriguez-Franco_2000_Arch.Pharm.(Weinheim)_333_118 |
| PubMedID: 10863795 |
| Title : New tacrine-huperzine A hybrids (huprines): highly potent tight-binding acetylcholinesterase inhibitors of interest for the treatment of Alzheimer's disease - Camps_2000_J.Med.Chem_43_4657 |
| Author(s) : Camps P , El Achab R , Morral J , Munoz-Torrero D , Badia A , Banos JE , Vivas NM , Barril X , Orozco M , Luque FJ |
| Ref : Journal of Medicinal Chemistry , 43 :4657 , 2000 |
| Abstract : |
| PubMedSearch : Camps_2000_J.Med.Chem_43_4657 |
| PubMedID: 11101357 |
| Title : Role of calcium on the modulation of spontaneous acetylcholine efflux by the D2 dopamine receptor subtype in rat striatal synaptosomes - Sanz_2000_Brain.Res_854_42 |
| Author(s) : Sanz AG , Badia A , Clos MV |
| Ref : Brain Research , 854 :42 , 2000 |
| Abstract : |
| PubMedSearch : Sanz_2000_Brain.Res_854_42 |
| PubMedID: 10784105 |
| Title : Synthesis, in vitro pharmacology, and molecular modeling of very potent tacrine-huperzine A hybrids as acetylcholinesterase inhibitors of potential interest for the treatment of Alzheimer's disease - Camps_1999_J.Med.Chem_42_3227 |
| Author(s) : Camps P , El Achab R , Gorbig DM , Morral J , Munoz-Torrero D , Badia A , Eladi Banos J , Vivas NM , Barril X , Orozco M , Luque FJ |
| Ref : Journal of Medicinal Chemistry , 42 :3227 , 1999 |
| Abstract : |
| PubMedSearch : Camps_1999_J.Med.Chem_42_3227 |
| PubMedID: 10464010 |
| Title : Synthesis and evaluation of tacrine-huperzine A hybrids as acetylcholinesterase inhibitors of potential interest for the treatment of Alzheimer's disease - Badia_1998_Bioorg.Med.Chem_6_427 |
| Author(s) : Badia A , Banos JE , Camps P , Contreras J , Gorbig DM , Munoz-Torrero D , Simon M , Vivas NM |
| Ref : Bioorganic & Medicinal Chemistry , 6 :427 , 1998 |
| Abstract : |
| PubMedSearch : Badia_1998_Bioorg.Med.Chem_6_427 |
| PubMedID: 9597187 |
| Title : Action on noradrenergic transmission of an anticholinesterase: 9-amino-1,2,3,4-tetrahydroacridine - Vivas_1995_Neuropharmacol_34_367 |
| Author(s) : Vivas NM , Marmol F , Salles J , Badia A , Dierssen M |
| Ref : Neuropharmacology , 34 :367 , 1995 |
| Abstract : |
| PubMedSearch : Vivas_1995_Neuropharmacol_34_367 |
| PubMedID: 7566467 |
| Title : Differential effects of physostigmine and 1,2,3,4-tetrahydro-9-aminoacridine on the beta-adrenoceptor transduction system - Vivas_1993_Eur.J.Pharmacol_245_9 |
| Author(s) : Vivas NM , Badia A , Marmol F , Dierssen M |
| Ref : European Journal of Pharmacology , 245 :9 , 1993 |
| Abstract : |
| PubMedSearch : Vivas_1993_Eur.J.Pharmacol_245_9 |
| PubMedID: 8386672 |
| Title : Comparative effects of velnacrine, tacrine and physostigmine on the twitch responses in the rat phrenic-hemidiaphragm preparation - Bosch_1993_Gen.Pharmacol_24_1101 |
| Author(s) : Bosch F , Morales M , Badia A , Banos JE |
| Ref : General Pharmacology , 24 :1101 , 1993 |
| Abstract : |
| PubMedSearch : Bosch_1993_Gen.Pharmacol_24_1101 |
| PubMedID: 8270168 |
| Title : Post-train administration of 9-amino-1,2,3,4-tetrahydroacridine enhances passive avoidance retention and decreases beta-adrenoceptor-linked cyclic AMP formation in middle-aged rats - Dierssen_1992_Brain.Res_586_117 |
| Author(s) : Dierssen M , Marmol F , Vivas NM , Clos MV , Badia A |
| Ref : Brain Research , 586 :117 , 1992 |
| Abstract : |
| PubMedSearch : Dierssen_1992_Brain.Res_586_117 |
| PubMedID: 1380875 |
| Title : Effects of velnacrine, tacrine and physostigmine on tetanic twitch responses at the rat neuromuscular junction - Bosch_1992_Eur.J.Pharmacol_222_163 |
| Author(s) : Bosch F , Morales M , Badia A , Banos JE |
| Ref : European Journal of Pharmacology , 222 :163 , 1992 |
| Abstract : |
| PubMedSearch : Bosch_1992_Eur.J.Pharmacol_222_163 |
| PubMedID: 1468493 |
| Title : Acute effects of tetrahydroaminoacridine on beta-adrenoceptor-linked cyclic AMP accumulation in brain of young and middle-aged rats - Dierssen_1991_Neurosci.Lett_132_51 |
| Author(s) : Dierssen M , Marmol F , Vivas NM , Clos MV , Gascon S , Badia A |
| Ref : Neuroscience Letters , 132 :51 , 1991 |
| Abstract : |
| PubMedSearch : Dierssen_1991_Neurosci.Lett_132_51 |
| PubMedID: 1724070 |