Badia A

References (38)

Title : Neuroprotective Effects of the Multitarget Agent AVCRI104P3 in Brain of Middle-Aged Mice - Relat_2018_Int.J.Mol.Sci_19_
Author(s) : Relat J , Come J , Perez B , Camps P , Munoz-Torrero D , Badia A , Gimenez-Llort L , Clos MV
Ref : Int J Mol Sci , 19 : , 2018
Abstract :
PubMedSearch : Relat_2018_Int.J.Mol.Sci_19_
PubMedID: 30181440

Title : Huprine X Attenuates The Neurotoxicity Induced by Kainic Acid, Especially Brain Inflammation - Relat_2018_Basic.Clin.Pharmacol.Toxicol_122_94
Author(s) : Relat J , Perez B , Camps P , Munoz-Torrero D , Badia A , Victoria Clos M
Ref : Basic Clin Pharmacol Toxicol , 122 :94 , 2018
Abstract :
PubMedSearch : Relat_2018_Basic.Clin.Pharmacol.Toxicol_122_94
PubMedID: 28724203

Title : Behavioural effects of novel multitarget anticholinesterasic derivatives in Alzheimer's disease - Gimenez-Llort_2017_Behav.Pharmacol_28_124
Author(s) : Gimenez-Llort L , Ratia M , Perez B , Camps P , Munoz-Torrero D , Badia A , Clos MV
Ref : Behav Pharmacol , 28 :124 , 2017
Abstract :
PubMedSearch : Gimenez-Llort_2017_Behav.Pharmacol_28_124
PubMedID: 28125507

Title : AVCRI104P3, a novel multitarget compound with cognition-enhancing and anxiolytic activities: Studies in cognitively poor middle-aged mice - Gimenez-Llort_2015_Behav.Brain.Res_286_97
Author(s) : Gimenez-Llort L , Ratia M , Perez B , Camps P , Munoz-Torrero D , Badia A , Clos MV
Ref : Behavioural Brain Research , 286 :97 , 2015
Abstract :
PubMedSearch : Gimenez-Llort_2015_Behav.Brain.Res_286_97
PubMedID: 25732954

Title : Undifferentiated and Differentiated PC12 Cells Protected by Huprines Against Injury Induced by Hydrogen Peroxide - Pera_2013_PLoS.One_8_e74344
Author(s) : Pera M , Camps P , Munoz-Torrero D , Perez B , Badia A , Clos Guillen MV
Ref : PLoS ONE , 8 :e74344 , 2013
Abstract :
PubMedSearch : Pera_2013_PLoS.One_8_e74344
PubMedID: 24086337

Title : Huprine X and Huperzine A Improve Cognition and Regulate Some Neurochemical Processes Related with Alzheimer's Disease in Triple Transgenic Mice (3xTg-AD) - Ratia_2013_Neurodegener.Dis_11_129
Author(s) : Ratia M , Gimenez-Llort L , Camps P , Munoz-Torrero D , Perez B , Clos MV , Badia A
Ref : Neurodegener Dis , 11 :129 , 2013
Abstract :
PubMedSearch : Ratia_2013_Neurodegener.Dis_11_129
PubMedID: 22626981

Title : Huprine-tacrine heterodimers as anti-amyloidogenic compounds of potential interest against Alzheimer's and prion diseases - Galdeano_2012_J.Med.Chem_55_661
Author(s) : Galdeano C , Viayna E , Sola I , Formosa X , Camps P , Badia A , Clos MV , Relat J , Ratia M , Bartolini M , Mancini F , Andrisano V , Salmona M , Minguillon C , Gonzalez-Munoz GC , Rodriguez-Franco MI , Bidon-Chanal A , Luque FJ , Munoz-Torrero D
Ref : Journal of Medicinal Chemistry , 55 :661 , 2012
Abstract :
PubMedSearch : Galdeano_2012_J.Med.Chem_55_661
PubMedID: 22185619

Title : Expanding the multipotent profile of huprine-tacrine heterodimers as disease-modifying anti-Alzheimer agents - Munoz-Torrero_2012_Neurodegener.Dis_10_96
Author(s) : Munoz-Torrero D , Pera M , Relat J , Ratia M , Galdeano C , Viayna E , Sola I , Formosa X , Camps P , Badia A , Clos MV
Ref : Neurodegener Dis , 10 :96 , 2012
Abstract :
PubMedSearch : Munoz-Torrero_2012_Neurodegener.Dis_10_96
PubMedID: 22236498

Title : Tacrine-based dual binding site acetylcholinesterase inhibitors as potential disease-modifying anti-Alzheimer drug candidates - Camps_2010_Chem.Biol.Interact_187_411
Author(s) : Camps P , Formosa X , Galdeano C , Gomez T , Munoz-Torrero D , Ramirez L , Viayna E , Gomez E , Isambert N , Lavilla R , Badia A , Clos MV , Bartolini M , Mancini F , Andrisano V , Bidon-Chanal A , Huertas O , Dafni T , Luque FJ
Ref : Chemico-Biological Interactions , 187 :411 , 2010
Abstract :
PubMedSearch : Camps_2010_Chem.Biol.Interact_187_411
PubMedID: 20167211

Title : Effect of huprine X on beta-amyloid, synaptophysin and alpha7 neuronal nicotinic acetylcholine receptors in the brain of 3xTg-AD and APPswe transgenic mice - Hedberg_2010_Neurodegener.Dis_7_379
Author(s) : Hedberg MM , Clos MV , Ratia M , Gonzalez D , Lithner CU , Camps P , Munoz-Torrero D , Badia A , Gimenez-Llort L , Nordberg A
Ref : Neurodegener Dis , 7 :379 , 2010
Abstract :
PubMedSearch : Hedberg_2010_Neurodegener.Dis_7_379
PubMedID: 20689242

Title : Novel huprine derivatives with inhibitory activity toward beta-amyloid aggregation and formation as disease-modifying anti-Alzheimer drug candidates - Viayna_2010_ChemMedChem_5_1855
Author(s) : Viayna E , Gomez T , Galdeano C , Ramirez L , Ratia M , Badia A , Clos MV , Verdaguer E , Junyent F , Camins A , Pallas M , Bartolini M , Mancini F , Andrisano V , Arce MP , Rodriguez-Franco MI , Bidon-Chanal A , Luque FJ , Camps P , Munoz-Torrero D
Ref : ChemMedChem , 5 :1855 , 2010
Abstract :
PubMedSearch : Viayna_2010_ChemMedChem_5_1855
PubMedID: 20859987

Title : Acetylcholinesterase as an amyloid enhancing factor in PrP82-146 aggregation process - Pera_2009_Mol.Cell.Neurosci_40_217
Author(s) : Pera M , Martinez-Otero A , Colombo L , Salmona M , Ruiz-Molina D , Badia A , Clos MV
Ref : Molecular & Cellular Neurosciences , 40 :217 , 2009
Abstract :
PubMedSearch : Pera_2009_Mol.Cell.Neurosci_40_217
PubMedID: 19038345

Title : Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds - Camps_2009_J.Med.Chem_52_5365
Author(s) : Camps P , Formosa X , Galdeano C , Munoz-Torrero D , Ramirez L , Gomez E , Isambert N , Lavilla R , Badia A , Clos MV , Bartolini M , Mancini F , Andrisano V , Arce MP , Rodriguez-Franco MI , Huertas O , Dafni T , Luque FJ
Ref : Journal of Medicinal Chemistry , 52 :5365 , 2009
Abstract :
PubMedSearch : Camps_2009_J.Med.Chem_52_5365
PubMedID: 19663388

Title : Novel donepezil-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation - Camps_2008_J.Med.Chem_51_3588
Author(s) : Camps P , Formosa X , Galdeano C , Gomez T , Munoz-Torrero D , Scarpellini M , Viayna E , Badia A , Clos MV , Camins A , Pallas M , Bartolini M , Mancini F , Andrisano V , Estelrich J , Lizondo M , Bidon-Chanal A , Luque FJ
Ref : Journal of Medicinal Chemistry , 51 :3588 , 2008
Abstract :
PubMedSearch : Camps_2008_J.Med.Chem_51_3588
PubMedID: 18517184

Title : Acetylcholinesterase triggers the aggregation of PrP 106-126 - Pera_2006_Biochem.Biophys.Res.Commun_346_89
Author(s) : Pera M , Roman S , Ratia M , Camps P , Munoz-Torrero D , Colombo L , Manzoni C , Salmona M , Badia A , Clos MV
Ref : Biochemical & Biophysical Research Communications , 346 :89 , 2006
Abstract :
PubMedSearch : Pera_2006_Biochem.Biophys.Res.Commun_346_89
PubMedID: 16750169

Title : Binding of 13-amidohuprines to acetylcholinesterase: exploring the ligand-induced conformational change of the gly117-gly118 peptide bond in the oxyanion hole - Camps_2006_J.Med.Chem_49_6833
Author(s) : Camps P , Gomez E , Munoz-Torrero D , Badia A , Clos MV , Curutchet C , Munoz-Muriedas J , Luque FJ
Ref : Journal of Medicinal Chemistry , 49 :6833 , 2006
Abstract :
PubMedSearch : Camps_2006_J.Med.Chem_49_6833
PubMedID: 17154513

Title : Effect of acetylcholinesterase inhibitors on AChE-induced PrP106-126 aggregation - Clos_2006_J.Mol.Neurosci_30_89
Author(s) : Clos MV , Pera M , Ratia M , Roman S , Camps P , Munoz-Torrero D , Colombo L , Salmona M , Badia A
Ref : Journal of Molecular Neuroscience , 30 :89 , 2006
Abstract :
PubMedSearch : Clos_2006_J.Mol.Neurosci_30_89
PubMedID: 17192641

Title : Synthesis and pharmacological evaluation of huprine-tacrine heterodimers: subnanomolar dual binding site acetylcholinesterase inhibitors - Camps_2005_J.Med.Chem_48_1701
Author(s) : Camps P , Formosa X , Munoz-Torrero D , Petrignet J , Badia A , Clos MV
Ref : Journal of Medicinal Chemistry , 48 :1701 , 2005
Abstract :
PubMedSearch : Camps_2005_J.Med.Chem_48_1701
PubMedID: 15771413

Title : Nicotinic-receptor potentiator drugs, huprine X and galantamine, increase ACh release by blocking AChE activity but not acting on nicotinic receptors - Roman_2005_Brain.Res_1061_73
Author(s) : Roman S , Badia A , Camps P , Munoz-Torrero D , Clos MV
Ref : Brain Research , 1061 :73 , 2005
Abstract :
PubMedSearch : Roman_2005_Brain.Res_1061_73
PubMedID: 16248990

Title : Potentiation effects of (+\/-)huprine X, a new acetylcholinesterase inhibitor, on nicotinic receptors in rat cortical synaptosomes - Roman_2004_Neuropharmacol_46_95
Author(s) : Roman S , Badia A , Camps P , Clos MV
Ref : Neuropharmacology , 46 :95 , 2004
Abstract :
PubMedSearch : Roman_2004_Neuropharmacol_46_95
PubMedID: 14654101

Title : Characterisation of the anticholinesterase activity of two new tacrine-huperzine A hybrids - Alcala_2003_Neuropharmacol_44_749
Author(s) : Alcala Mdel M , Vivas NM , Hospital S , Camps P , Munoz-Torrero D , Badia A
Ref : Neuropharmacology , 44 :749 , 2003
Abstract :
PubMedSearch : Alcala_2003_Neuropharmacol_44_749
PubMedID: 12681373

Title : Synthesis and Acetylcholinesterase\/Butyrylcholinesterase Inhibition Activity of 4-Amino-2, 3-diaryl-5, 6, 7, 8-tetrahydrofuro(and thieno)[2, 3-b]-quinolines, and 4-Amino-5, 6, 7, 8, 9-pentahydro-2, 3-diphenylcyclohepta[e]furo(and thieno)-[2, 3-b]pyridines - Marco_2002_Arch.Pharm.(Weinheim)_335_347
Author(s) : Marco JL , de los Rios C , Carreiras MC , Banos JE , Badia A , Vivas NM
Ref : Arch Pharm (Weinheim) , 335 :347 , 2002
Abstract :
PubMedSearch : Marco_2002_Arch.Pharm.(Weinheim)_335_347
PubMedID: 12207285

Title : Interaction of a new potent anticholinesterasic compound (+\/-)huprine X with muscarinic receptors in rat brain - Roman_2002_Neurosci.Lett_325_103
Author(s) : Roman S , Vivas NM , Badia A , Clos MV
Ref : Neuroscience Letters , 325 :103 , 2002
Abstract :
PubMedSearch : Roman_2002_Neurosci.Lett_325_103
PubMedID: 12044632

Title : Synthesis and acetylcholinesterase\/butyrylcholinesterase inhibition activity of new tacrine-like analogues - Marco_2001_Bioorg.Med.Chem_9_727
Author(s) : Marco JL , de los Rios C , Carreiras MC , Banos JE , Badia A , Vivas NM
Ref : Bioorganic & Medicinal Chemistry , 9 :727 , 2001
Abstract :
PubMedSearch : Marco_2001_Bioorg.Med.Chem_9_727
PubMedID: 11310608

Title : Synthesis, in Vitro Pharmacology, and Molecular Modeling of syn-Huprines as Acetylcholinesterase Inhibitors - Camps_2001_J.Med.Chem_44_4733
Author(s) : Camps P , Gomez E , Munoz-Torrero D , Badia A , Vivas NM , Barril X , Orozco M , Luque FJ
Ref : Journal of Medicinal Chemistry , 44 :4733 , 2001
Abstract :
PubMedSearch : Camps_2001_J.Med.Chem_44_4733
PubMedID: 11741490

Title : The pharmacology of novel acetylcholinesterase inhibitors, (+\/-)- huprines Y and X, on the Torpedo electric organ - Ros_2001_Eur.J.Pharmacol_421_77
Author(s) : Ros E , Aleu J , Gomez de Aranda I , Munoz-Torrero D , Camps P , Badia A , Marsal J , Solsona C
Ref : European Journal of Pharmacology , 421 :77 , 2001
Abstract :
PubMedSearch : Ros_2001_Eur.J.Pharmacol_421_77
PubMedID: 11399262

Title : N-Benzylpiperidine derivatives of 1,2,4-thiadiazolidinone as new acetylcholinesterase inhibitors - Martinez_2000_Eur.J.Med.Chem_35_913
Author(s) : Martinez A , Fernandez E , Castro A , Conde S , Rodriguez-Franco I , Banos JE , Badia A
Ref : Eur Journal of Medicinal Chemistry , 35 :913 , 2000
Abstract :
PubMedSearch : Martinez_2000_Eur.J.Med.Chem_35_913
PubMedID: 11121617

Title : Synthesis of new N-(4-pyridyl)-1-aminopyrazoles and their muscarinic and adrenergic properties - Rodriguez-Franco_2000_Arch.Pharm.(Weinheim)_333_118
Author(s) : Rodriguez-Franco MI , Dorronsoro I , Martinez A , Perez C , Badia A , Banos JE
Ref : Arch Pharm (Weinheim) , 333 :118 , 2000
Abstract :
PubMedSearch : Rodriguez-Franco_2000_Arch.Pharm.(Weinheim)_333_118
PubMedID: 10863795

Title : Role of calcium on the modulation of spontaneous acetylcholine efflux by the D2 dopamine receptor subtype in rat striatal synaptosomes - Sanz_2000_Brain.Res_854_42
Author(s) : Sanz AG , Badia A , Clos MV
Ref : Brain Research , 854 :42 , 2000
Abstract :
PubMedSearch : Sanz_2000_Brain.Res_854_42
PubMedID: 10784105

Title : New tacrine-huperzine A hybrids (huprines): highly potent tight-binding acetylcholinesterase inhibitors of interest for the treatment of Alzheimer's disease - Camps_2000_J.Med.Chem_43_4657
Author(s) : Camps P , El Achab R , Morral J , Munoz-Torrero D , Badia A , Banos JE , Vivas NM , Barril X , Orozco M , Luque FJ
Ref : Journal of Medicinal Chemistry , 43 :4657 , 2000
Abstract :
PubMedSearch : Camps_2000_J.Med.Chem_43_4657
PubMedID: 11101357

Title : Synthesis, in vitro pharmacology, and molecular modeling of very potent tacrine-huperzine A hybrids as acetylcholinesterase inhibitors of potential interest for the treatment of Alzheimer's disease - Camps_1999_J.Med.Chem_42_3227
Author(s) : Camps P , El Achab R , Gorbig DM , Morral J , Munoz-Torrero D , Badia A , Eladi Banos J , Vivas NM , Barril X , Orozco M , Luque FJ
Ref : Journal of Medicinal Chemistry , 42 :3227 , 1999
Abstract :
PubMedSearch : Camps_1999_J.Med.Chem_42_3227
PubMedID: 10464010

Title : Synthesis and evaluation of tacrine-huperzine A hybrids as acetylcholinesterase inhibitors of potential interest for the treatment of Alzheimer's disease - Badia_1998_Bioorg.Med.Chem_6_427
Author(s) : Badia A , Banos JE , Camps P , Contreras J , Gorbig DM , Munoz-Torrero D , Simon M , Vivas NM
Ref : Bioorganic & Medicinal Chemistry , 6 :427 , 1998
Abstract :
PubMedSearch : Badia_1998_Bioorg.Med.Chem_6_427
PubMedID: 9597187

Title : Action on noradrenergic transmission of an anticholinesterase: 9-amino-1,2,3,4-tetrahydroacridine - Vivas_1995_Neuropharmacol_34_367
Author(s) : Vivas NM , Marmol F , Salles J , Badia A , Dierssen M
Ref : Neuropharmacology , 34 :367 , 1995
Abstract :
PubMedSearch : Vivas_1995_Neuropharmacol_34_367
PubMedID: 7566467

Title : Comparative effects of velnacrine, tacrine and physostigmine on the twitch responses in the rat phrenic-hemidiaphragm preparation - Bosch_1993_Gen.Pharmacol_24_1101
Author(s) : Bosch F , Morales M , Badia A , Banos JE
Ref : General Pharmacology , 24 :1101 , 1993
Abstract :
PubMedSearch : Bosch_1993_Gen.Pharmacol_24_1101
PubMedID: 8270168

Title : Differential effects of physostigmine and 1,2,3,4-tetrahydro-9-aminoacridine on the beta-adrenoceptor transduction system - Vivas_1993_Eur.J.Pharmacol_245_9
Author(s) : Vivas NM , Badia A , Marmol F , Dierssen M
Ref : European Journal of Pharmacology , 245 :9 , 1993
Abstract :
PubMedSearch : Vivas_1993_Eur.J.Pharmacol_245_9
PubMedID: 8386672

Title : Effects of velnacrine, tacrine and physostigmine on tetanic twitch responses at the rat neuromuscular junction - Bosch_1992_Eur.J.Pharmacol_222_163
Author(s) : Bosch F , Morales M , Badia A , Banos JE
Ref : European Journal of Pharmacology , 222 :163 , 1992
Abstract :
PubMedSearch : Bosch_1992_Eur.J.Pharmacol_222_163
PubMedID: 1468493

Title : Post-train administration of 9-amino-1,2,3,4-tetrahydroacridine enhances passive avoidance retention and decreases beta-adrenoceptor-linked cyclic AMP formation in middle-aged rats - Dierssen_1992_Brain.Res_586_117
Author(s) : Dierssen M , Marmol F , Vivas NM , Clos MV , Badia A
Ref : Brain Research , 586 :117 , 1992
Abstract :
PubMedSearch : Dierssen_1992_Brain.Res_586_117
PubMedID: 1380875

Title : Acute effects of tetrahydroaminoacridine on beta-adrenoceptor-linked cyclic AMP accumulation in brain of young and middle-aged rats - Dierssen_1991_Neurosci.Lett_132_51
Author(s) : Dierssen M , Marmol F , Vivas NM , Clos MV , Gascon S , Badia A
Ref : Neuroscience Letters , 132 :51 , 1991
Abstract :
PubMedSearch : Dierssen_1991_Neurosci.Lett_132_51
PubMedID: 1724070