| Title : Synthesis of new 3, 4-dihydropyrano [c] chromene derivatives and their evaluation as acetyl cholinesterase inhibitors - Bouazizi_2014_Eur.J.Chem_5_457 |
| Author(s) : Bouazizi Y , Romdhane A , Ben Jannet H |
| Ref : European Journal of Chemistry , 5 :457 , 2014 |
|
Abstract :
2-Amino-4-phenyl-4,5-dihydro-5-oxopyrano[2,3-c]chromen-3-carbonitrile derivatives (8a-d) have been isolated in good yields by the reaction of corresponding 4-hydroxycoumarin (1) with substituted aldehydes (2a-d) and malononitrile (3) under reflux conditions. The reactivity of a-functionalized iminoethers (9a-d) with hydrazine, hydroxylamine and piperidine was studied. The synthesized compounds were characterized by various techniques including spectroscopy. Compounds 8-11 were also evaluated as potential acetylcholinesterase inhibitors. |
| PubMedSearch : Bouazizi_2014_Eur.J.Chem_5_457 |
| PubMedID: |
| Inhibitor | AChE-IN-27 |
Bouazizi Y, Romdhane A, Ben Jannet H (2014)
Synthesis of new 3, 4-dihydropyrano [c] chromene derivatives and their evaluation as acetyl cholinesterase inhibitors
European Journal of Chemistry
5 :457
Bouazizi Y, Romdhane A, Ben Jannet H (2014)
European Journal of Chemistry
5 :457