Braun_2017_Biomed.Pharmacother_88_1054

Reference

Title : Neuroprotective effects of pretreatment with quercetin as assessed by acetylcholinesterase assay and behavioral testing in poloxamer-407 induced hyperlipidemic rats - Braun_2017_Biomed.Pharmacother_88_1054
Author(s) : Braun JB , Ruchel JB , Adefegha SA , Coelho AP , Trelles KB , Signor C , Rubin MA , Oliveira JS , Dornelles GL , de Andrade CM , Castilhos LG , Leal DB
Ref : Biomed Pharmacother , 88 :1054 , 2017
Abstract :

Hyperlipidemia is a group of disorders characterized by excessive lipids in the bloodstream. It is associated with the incidence of cardiovascular diseases and recognized as the most important factor underlying the occurrence of atherosclerosis. This study was conducted to investigate whether pretreatment with quercetin can protect against possible memory impairment and deterioration of the cholinergic system in hyperlipidemic rats. Animals were divided into ten groups (n=7): saline/control, saline/quercetin 5mg/kg, saline/quercetin 25mg/kg, saline/quercetin 50mg/kg, saline/simvastatin (0.04mg/kg), hyperlipidemia, hyperlipidemia/quercetin 5mg/kg, hyperlipidemia/quercetin 25mg/kg, hyperlipidemia/quercetin 50mg/kg and hyperlipidemia/simvastatin. The animals were pretreated with quercetin by oral gavage for a period of 30days and hyperlipidemia was subsequently induced by intraperitoneal administration of a single dose of 500mg/kg of poloxamer-407. Simvastatin was administered after the induction of hyperlipidemia. The results demonstrated that hyperlipidemic rats had memory impairment compared with the saline control group (P<0.001). However, pretreatment with quercetin and simvastatin treatment attenuated the damage caused by hyperlipidemia compared with the hyperlipidemic group (P<0.05). Acetylcholinesterase (AChE) activity in the cerebral hippocampus was significantly (P<0.001) reduced in the hyperlipidemic group compared with the control saline group. Pretreatment with quercetin and simvastatin treatment in the hyperlipidemic groups significantly (P<0.05) increased AChE activity compared with the hyperlipidemic group. Our results thus suggest that quercetin may prevent memory impairment, alter lipid metabolism, and modulate AChE activity in an experimental model of hyperlipidemia.

PubMedSearch : Braun_2017_Biomed.Pharmacother_88_1054
PubMedID: 28192878

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Citations formats

Braun JB, Ruchel JB, Adefegha SA, Coelho AP, Trelles KB, Signor C, Rubin MA, Oliveira JS, Dornelles GL, de Andrade CM, Castilhos LG, Leal DB (2017)
Neuroprotective effects of pretreatment with quercetin as assessed by acetylcholinesterase assay and behavioral testing in poloxamer-407 induced hyperlipidemic rats
Biomed Pharmacother 88 :1054

Braun JB, Ruchel JB, Adefegha SA, Coelho AP, Trelles KB, Signor C, Rubin MA, Oliveira JS, Dornelles GL, de Andrade CM, Castilhos LG, Leal DB (2017)
Biomed Pharmacother 88 :1054