| Title : Aging reduces ABHD5 protein content in the adipose tissue of mice: The reversal effect of exercise - Bricola_2022_Cell.Biochem.Funct__ |
| Author(s) : Bricola RS , Cordeiro AV , Crisol BM , Braga RR , de Melo DG , Rocha MB , Gaspar RC , Nakandakari S , Silva VRR , Anaruma CP , Katashima CK , Canciglieri RDS , Munoz VR , Pavan ICB , Pinto AP , Simabuco FM , Silva A , Moura LP , Pauli JR , Cintra DE , Ropelle ER |
| Ref : Cell Biochemistry & Function , : , 2022 |
|
Abstract :
Dysfunction of the adipose tissue metabolism is considered as a significant hallmark of aging. It has been proposed that alpha-beta hydrolase domain containing 5 (ABHD5) plays a critical role in the control of lipolysis. However, the role of ABHD5 in the control of lipolysis during aging or exercise is unknown. Here we combined the experimental mouse model with transcriptomic analyzes by using murine and human databases to explore the role of ABHD5 in the adipose tissue during aging and in response to exercise. Transcriptomic data revealed a downregulation of Abhd5 messenger RNA levels in the subcutaneous white adipose tissue (scWAT) over time in individuals from 20 to 69 years old. Aged mice displayed dramatic reduction of ABHD5 protein content and lipolytic-related proteins in the scWAT. Interestingly, 4 weeks of high-intensity interval training increased ABHD5 protein level and restored the lipolytic pathway in the scWAT of aged mice. Altogether, our findings demonstrated that aging affects ABHD5 content in the adipose tissue of mice and humans. Conversely, exercise increases ABHD5 activity, recovering the lipolytic activity in aged mice. |
| PubMedSearch : Bricola_2022_Cell.Biochem.Funct__ |
| PubMedID: 36515301 |
| Gene_locus related to this paper: human-ABHD5 , mouse-abhd5 |
| Gene_locus | human-ABHD5 mouse-abhd5 |
| Family | CGI-58_ABHD5_ABHD4 |
Bricola RS, Cordeiro AV, Crisol BM, Braga RR, de Melo DG, Rocha MB, Gaspar RC, Nakandakari S, Silva VRR, Anaruma CP, Katashima CK, Canciglieri RDS, Munoz VR, Pavan ICB, Pinto AP, Simabuco FM, Silva A, Moura LP, Pauli JR, Cintra DE, Ropelle ER (2022)
Aging reduces ABHD5 protein content in the adipose tissue of mice: The reversal effect of exercise
Cell Biochemistry & Function
:
Bricola RS, Cordeiro AV, Crisol BM, Braga RR, de Melo DG, Rocha MB, Gaspar RC, Nakandakari S, Silva VRR, Anaruma CP, Katashima CK, Canciglieri RDS, Munoz VR, Pavan ICB, Pinto AP, Simabuco FM, Silva A, Moura LP, Pauli JR, Cintra DE, Ropelle ER (2022)
Cell Biochemistry & Function
: