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CGI-58_ABHD5_ABHD4

Relationship

Family: CGI-58_ABHD5_ABHD4

Block: X

Parent Family: Abhydrolase_6

Comment

Comparative gene identification 58 (CGI-58)/Alpha Beta Hydrolase Domain 5 (ABHD5) NCIE2 functions as an acyltransferase for the synthesis of phosphatidic acid, the major intermediate in membrane and storage lipid biosynthesis. It also functions as a coactivator of adipocyte triglyceride lipase (ATGL, or PNPLA2) (Ghosh et al., 2008) It also interacts with PNPLA9 (Guerrero-Santoro et al). CGI-58 is regulated by its interaction with perilipin 1 (PLIN1) localized on the lipid droplet (LD), and its release is controlled by phosphorylation. Once lipolysis is stimulated by catecholamines, protein kinase A (PKA)-mediated phosphorylation enables the dissociation of the CGI-58/PLIN1 complex, thereby recruiting adipose triglyceride lipase (ATGL) and hormone-sensitive lipase (HSL) to initiate fatty acid release. Mutations in CGI-58 were found in Chanarin-Dorfman syndrome. (from OMIM) By examining the critical region for triglyceride storage disease with impaired long-chain fatty acid oxidation, a rare autosomal recessive form of NCIE (242100), on chromosome 3p21, Lefevre et al.(2001) identified several candidate genes, one of which was designated comparative gene identification-58 (human-ABHD5). Lefevre et al. (2001) identified 8 different haplotypes and mutations in the human-ABHD5 gene. The disease locus was designated NCIE2. ABHD5_CGI58 is an activator of the adipose triglyceride lipase (TAG lipase, PNPLA2.patatin-like phospholipase domain-containing). ABHD5 CGI-58 proteins orthologs from plants and yeast are weak triglyceride and phospholipid hydrolases. In plants it interacts with peroxisomal transport protein PXA1. PNPLA3/Adiponutrin and ATGL(PNPLA2 patatin) compete for interaction with ABHD5 (Yang et al.). Comparative gene identification 58 (CGI-58)/Alpha Beta Hydrolase Domain 5 (ABHD5) lacks lysophosphatidic acid acyltransferase activity (McMahon et al.). Disruption of the Arabidopsis CGI-58 homologue produces Chanarin-Dorfman-like lipid droplet accumulation in plants (James et al.). ABHD5 is in fact a protease and hydrolyses HDAC4. Through the production of an amino-terminal polypeptide of HDAC4 (HDAC4-NT) in heart, ABHD5 inhibits MEF2-dependent gene expression and thereby controls glucose handling (Jabessa et al. 2019). Two highly conserved ABHD5 amino acids (R299 and G328) enabled ABHD4 (ABHD4 N303R/S332G) to activate ATGL. The corresponding ABHD5 mutations (ABHD5 R299N and ABHD5 G328S) selectively disrupted lipolysis without affecting ATGL lipid droplet translocation or ABHD5 interactions with perilipin proteins and ABHD5 ligands Sanders et al. In Drosophila Pummelig (Puml,colloquial German for chubby) pummelig deletion mutants (puml1) (Hehlert et al.) Pummelig release fatty acids from phosphatidic acid (PA), N-acylphosphatidylethanolamine (NAPE) and phosphatidylglycerol (PG) but does not hydrolyse TG, diolen or monoolein. Pummelig localizes to lipid droplets, mitochondria, and peroxisomes. CIDEC (Cell death-inducing DNA fragmentation factor-like effector C) regulates the enzymatic activity of adipose triglyceride lipase via interacting with its activator, CGI-58. Main substrates include: ABHD5 arachidonoyl-CoA, oleoyl-CoA, 1-oleoyl-lysophosphatidic, triacylglycerols

Database

Interpro : No interpro

PIRSF : No PIRSF

Pdoc : No Pdoc

Pfam : PF12697 Abhydrolase_6

Prints : No Print

EC Number : No EC Number

Sequences

Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour / coloured with Mview
Alignment with MAFFT No colour / coloured with Mview
Dendrogram The dnd file

Structure Name Proteins
5A4H Solution structure of the lipid droplet anchoring peptide of CGI-58 bound to DPC micelles human-ABHD5

Gene_locus Name Species
bommo-ABHD5 Bombyx mori (Silk moth) AB hydrolase-1 domain-containing protein ABHD5 BmABHD5 Bombyx mori
aedae-q16y39 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) Putative uncharacterized protein Aedes aegypti
aedae-q16y40 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) Putative uncharacterized protein Aedes aegypti
ailme-d2htv3 Ailuropoda melanoleuca (Giant panda) Putative uncharacterized protein Ailuropoda melanoleuca
ailme-d2hwy7 Ailuropoda melanoleuca (Giant panda) Putative uncharacterized protein Ailuropoda melanoleuca
ajecg-c0nsq8 Ajellomyces capsulata (Darling's disease fungus (Histoplasma capsulatum)) Abhydrolase domain-containing protein Ajellomyces capsulata
ajecn-a6ram0 Ajellomyces capsulata (strain NAm1 \/ WU24) (Darling's disease fungus) (Histoplasma capsulatum)) Putative uncharacterized protein Ajellomyces capsulata
ajedr-c5gsx8 Ajellomyces dermatitidis (strains ER-3\; SLH14081) (Blastomyces dermatitidis) Alpha\/beta hydrolase Ajellomyces dermatitidis
anoga-AGCG51454 Anopheles gambiae str. PEST agcp7312 (fragment) Anopheles gambiae
anoga-AGCG53245 Anopheles gambiae str. PEST agcp11171 (fragment) Anopheles gambiae
arath-LPAAT Arabidopsis thaliana (Mouse-ear cress) 1-acylglycerol-3-phosphate O-acyltransferase t19f06.4 At4g24160 T19F6_150 Arabidopsis thaliana
artbc-d4b5r3 Arthroderma benhamiae (strain CBS 112371) (Trichophyton mentagrophytes) Putative uncharacterized protein Arthroderma benhamiae
artoc-c5flu5 Arthroderma otae (strain CBS 113480) (Microsporum canis) Abhydrolase domain-containing protein 5 Arthroderma otae
ashgo-q74zz5 Ashbya gossypii ATCC 10895 agr062cp Ashbya gossypii ATCC 10895
ashgo-q75dn6 Ashbya gossypii ATCC 10895 abl019wp Ashbya gossypii ATCC 10895
aspcl-a1crr5 Aspergillus clavatus (strain ATCC 1007 \/ CBS 513.65 \/ DSM 816 \/ NCT3887 \/ NRRL 1) Alpha\/beta hydrolase, putative Aspergillus clavatus
aspfu-q4wk31 Aspergillus fumigatus Af293 and Neosartorya fumigata (strain CEA10\/CBS144.89\/FGSC A1163) (Aspergillus fumigatus) alpha\/beta hydrolase, putative Aspergillus fumigatus Af293
aspnc-a2q814 Aspergillus niger (strain CBS 513.88 \/ FGSC A1513) Putative uncharacterized protein An01g02690 Aspergillus niger
aspor-q2uk42 Aspergillus oryzae and Aspergillus flavus (strain ATCC200026\/FGSCA1120\/NRRL3357\/JC12722\/SRRC167) predicted hydrolase\/acyltransferase Aspergillus oryzae
asptn-q0cr64 Aspergillus terreus (strain NIH 2624 \/ FGSC A1156) Putative uncharacterized protein Aspergillus terreus
botfb-a6sgm2 Botryotinia fuckeliana (strain B05.10) (Noble rot fungus) (Botrytis cinerea) Putative uncharacterized protein Botryotinia fuckeliana
bovin-abhd4 Bos taurus (Bovine) abhydrolase domain containing protein 4 Lyso-N-acylphosphatidylethanolamine lipase Bos taurus
bovin-q0vcc8 Bos taurus (Bovine) Abhydrolase domain containing 5 Bos taurus
brafl-c3yi63 Branchiostoma floridae (Florida lancelet) (Amphioxus) Putative uncharacterized protein Branchiostoma floridae
brafl-c3yi64 Branchiostoma floridae (Florida lancelet) (Amphioxus) Putative uncharacterized protein Branchiostoma floridae
brafl-c3yi67 Branchiostoma floridae (Florida lancelet) (Amphioxus) Putative uncharacterized protein Branchiostoma floridae
brafl-c3yi68 Branchiostoma floridae (Florida lancelet) (Amphioxus) Putative uncharacterized protein Branchiostoma floridae
brafl-c3yi69 Branchiostoma floridae (Florida lancelet) (Amphioxus) Putative uncharacterized protein Branchiostoma floridae
brafl-c3yla7 Branchiostoma floridae (Florida lancelet) (Amphioxus) Putative uncharacterized protein Branchiostoma floridae
bruma-a8pah3 Brugia malayi (Filarial nematode worm) Hydrolase, alpha\/beta fold family protein Brugia malayi
caebr-a8x7h0 Caenorhabditis briggsae cbg08821 Putative uncharacterized protein Caenorhabditis briggsae
caebr-A8XEY7 Caenorhabditis briggsae hypothetical protein cbg12221 Caenorhabditis briggsae
caeel-C25A1.12 Caenorhabditis elegans c25a1.12 protein Caenorhabditis elegans
caeel-C37H5.2 Caenorhabditis elegans similar to acetyltransferases Caenorhabditis elegans
caeel-C37H5.3 Caenorhabditis elegans Abhydrolase domain-containing protein abhd-5.2 Caenorhabditis elegans
canal-q5a0c9 Candida albicans (strains WO-1\; SC5314) (Yeast) Candida dubliniensis (strain CD36 \/ CBS 7987 \/ NCPF 3949 \/ NRR Y-17841) hypothetical protein YGR110W homologue Candida albicans
canal-q5aeu3 Candida albicans (strain\; SC5314\; WO-1) (Yeast) potential mitochondrial protein involved in cell wall biogenesis Candida albicans
canal-q59ng0 Candida albicans SC5314 cardiolipin-specific phospholipase Candida albicans SC5314
canal-q59y42 Candida albicans SC5314 hypothetical protein Candida albicans SC5314
canal-q59y97 Candida albicans (strains SC5314\; WO-1) (Yeast)hypothetical protein Candida albicans SC5314
candc-b9wce3 Candida dubliniensis (strain CD36 \/ CBS 7987 \/ NCPF 3949 \/ NRR Y-17841) (Yeast) Putative uncharacterized protein Candida dubliniensis
candc-b9wds3 Candida dubliniensis (Yeast) Mitochondrial protein involved in cell wall biogenesis, (Protein ecm18 (Extracellular mutant protein 18) Candida dubliniensis
candc-b9wid3 Candida dubliniensis (strain CD36 \/ CBS 7987 \/ NCPF 3949 \/ NRR Y-17841) (Yeast) Alpha\/beta hydrolase, putative Candida dubliniensis
canga-q6fiv5 Candida glabrata (Yeast) (Torulopsis glabrata) similar to sp|q12385 saccharomyces cerevisiae ylr099c ict1 Candida glabrata
canga-q6flb5 Candida glabrata (Yeast) (Torulopsis glabrata) similar to sp|p53264 saccharomyces cerevisiae ygr110w Candida glabrata
canga-q6fxc7 Candida glabrata (Yeast) (Torulopsis glabrata) similar to tr|q04623 saccharomyces cerevisiae ydr125c ecm18 Candida glabrata
cantt-c5m4x0 Candida tropicalis (strain ATCC MYA-3404 \/ T1) (Yeast) Putative uncharacterized protein Candida tropicalis
cantt-c5m9c2 Candida tropicalis (strain ATCC MYA-3404 \/ T1) (Yeast) Putative uncharacterized protein Candida tropicalis
cantt-c5m893 Candida tropicalis (strain ATCC MYA-3404 \/ T1) (Yeast) Putative uncharacterized protein Candida tropicalis
cantt-c5mgj0 Candida tropicalis (strain ATCC MYA-3404 \/ T1) (Yeast) Putative uncharacterized protein Candida tropicalis
chagb-q2h2n3 Chaetomium globosum CBS 148.51 hypothetical protein Chaetomium globosum CBS 148.51
chick-b3tzb3 Gallus gallus (Chicken) Uncharacterized protein Gallus gallus
chlre-a8jd32 Chlamydomonas reinhardtii (Chlamydomonas smithii) Predicted protein Chlamydomonas reinhardtii
clal4-c4y7z7 Clavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae) Putative uncharacterized protein Clavispora lusitaniae
clal4-c4y035 Clavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae) Putative uncharacterized protein Clavispora lusitaniae
clal4-c4y898 Clavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae) Putative uncharacterized protein Clavispora lusitaniae
clal4-c4yas2 Clavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae) Putative uncharacterized protein Clavispora lusitaniae
cocp7-c5p0i6 Coccidioides posadasii (strain C735) (Valley fever fungus) Alpha\/beta hydrolase fold family protein Coccidioides posadasii
copc7-a8nwm2 Coprinopsis cinerea (strain Okayama-7 \/ 130 \/ FGSC 9003) (Inky can fungus) (Hormographiella aspergillata) Abhydrolase domain-containing protein 4 Coprinopsis cinerea
cryne-q5khb9 Cryptococcus neoformans (Filobasidiella neoformans)(and var. neoformans B-3501A) hypothetical protein Cryptococcus neoformans
culqu-b0wpg8 Culex quinquefasciatus (Southern house mosquito) (Culex pungens) Abhydrolase domain-containing protein 4 Culex quinquefasciatus
danre-q568j2 Danio rerio (Zebrafish) (Brachydanio rerio) hypothetical protein zgc:110267 Danio rerio
debha-q6biq7 Debaryomyces hansenii (Yeast) (Torulaspora hansenii) hansenii Debaryomyces hansenii
debha-q6bj53 Debaryomyces hansenii (Yeast) (Torulaspora hansenii)unknown function Debaryomyces hansenii
debha-q6bkd8 Debaryomyces hansenii (Yeast) (Torulaspora hansenii) similar to ca5301|ipf2186 candida albicans ipf2186 Debaryomyces hansenii
debha-q6bw82 Debaryomyces hansenii (Yeast) (Torulaspora hansenii) biogenesis Debaryomyces hansenii
droan-b3mg94 Drosophila ananassae (Fruit fly) GF13636 Drosophila ananassae
droer-b3n9e1 Drosophila erecta (Fruit fly) GG23305 Drosophila erecta
drogr-b4j4x9 Drosophila grimshawi (Fruit fly) (Idiomyia grimshawi) GH20321 Drosophila grimshawi
drome-CG1882 Drosophila melanogaster (Fruit fly) Pummelig (Puml) phospholipase Drosophila melanogaster
dromo-b4ksy6 Drosophila mojavensis (Fruit fly) GI19993 Drosophila mojavensis
drope-b4gdk2 Drosophila persimilis (Fruit fly) GL10842 Drosophila persimilis
drope-b4gkf4 Drosophila persimilis (Fruit fly) GL25694 Drosophila persimilis
drops-b5dhd2 Drosophila pseudoobscura pseudoobscura (Fruit fly) GA25396 GA29248 Drosophila pseudoobscura pseudoobscura
drops-q292g6 Drosophila pseudoobscura (Fruit fly) ga15096-pa (fragment) Drosophila pseudoobscura
drose-b4hr81 Drosophila sechellia (Fruit fly) GM20984 Drosophila sechellia
drosi-b4qet1 Drosophila simulans (Fruit fly) GD10511 Drosophila simulans
drovi-b4lmk4 Drosophila virilis (Fruit fly) GJ21242 Drosophila virilis
drowi-b4mug2 Drosophila willistoni (Fruit fly) GK14854 Drosophila willistoni
drowi-b4myh5 Drosophila willistoni (Fruit fly) GK22221 Drosophila willistoni
droya-b4p241 Drosophila yakuba (Fruit fly) GE19151 Drosophila yakuba
emeni-q5b5y4 Aspergillus nidulans FGSC A4 hypothetical protein putative (AFU_orthologue\; AFUA_1G03890) Aspergillus nidulans FGSC A4
gibze-q4icq0 Gibberella zeae (Fusarium graminearum) AB hydrolase-1 domain-containing protein Gibberella zeae
glomm-d3tp96 Glossina morsitans morsitans (Savannah tsetse fly) Putative hydrolase\/acyltransferase Glossina morsitans morsitans
human-ABHD4 Homo sapiens (Human) abhydrolase domain-containing protein 4 FLJ12816 similar to 2-hydroxymuconic semialdehyde hydrolase (EC 3.1.1.-) Homo sapiens
human-ABHD5 Homo sapiens (Human) 39.1 kDa Comparative gene identification 58 (CGI-58)\/Alpha Beta Hydrolase Domain 5 (ABHD5) Homo sapiens
ixosc-b7psu1 Ixodes scapularis (Black-legged tick) (Deer tick) Abhydrolase domain-containing protein, putative Ixodes scapularis
klula-q6cjc8 Kluyveromyces lactis (Yeast) 1140 of kluyveromyces lactis Kluyveromyces lactis
klula-q6cvd3 Kluyveromyces lactis (Yeast) similar to sp|p53264 saccharomyces cerevisiae ygr110w singleton Kluyveromyces lactis
lacbs-b0cuw1 Laccaria bicolor (strain S238N-H82) (Bicoloured deceiver) (Laccaria laccata var. bicolor) Predicted protein Laccaria bicolor
lactc-c5ddi5 Lachancea thermotolerans (strain CBS 6340) (Yeast) (Kluyveromyces thermotolerans) KLTH0C01254p Lachancea thermotolerans
lactc-c5din7 Lachancea thermotolerans (strain CBS 6340) (Yeast) (Kluyveromyces thermotolerans) KLTH0E13948p Lachancea thermotolerans
lactc-c5dn06 Lachancea thermotolerans (strain CBS 6340) (Yeast) (Kluyveromyces thermotolerans) KLTH0G13178p Lachancea thermotolerans
lodel-a5dxf3 Lodderomyces elongisporus (strain ATCC 11503 \/ CBS 2605 \/ JCM 1781 \/ NBRC 1676 \/ NRRL YB-4239) (Yeast) (Saccharomyces elongisporus) Putative uncharacterized protein Lodderomyces elongisporus
lodel-a5e4u8 Lodderomyces elongisporus (strain ATCC 11503 \/ CBS 2605 \/ JCM 1781 \/ NBRC 1676 \/ NRRL YB-4239) (Yeast) (Saccharomyces elongisporus) Putative uncharacterized protein Lodderomyces elongisporus
lodel-a5e5z7 Lodderomyces elongisporus (strain ATCC 11503 \/ CBS 2605 \/ JCM 1781 NBRC 1676 \/ NRRL YB-4239) (Yeast) (Saccharomyces elongisporus) Putative uncharacterized protein Lodderomyces elongisporus
mago7-a4qvx8 Magnaporthe oryzae (strain 70-15 \/ FGSC 8958) (Rice blast fungus) (Pyricularia oryzae) Alpha\/beta hydrolase Magnaporthe oryzae
maize-b4faq7 Zea mays (Maize) Putative uncharacterized protein Zea mays
malgo-a8q1i5 Malassezia globosa (strain ATCC 96807 \/ CBS 7966) (Dandruff-associated fungus) Putative uncharacterized protein Malassezia globosa
micsr-c1eii9 Micromonas sp. (strain RCC299 \/ NOUM17) (Picoplanktonic green alga) Predicted protein Micromonas sp.
monbe-a9vbp2 Monosiga brevicollis (Choanoflagellate) Predicted protein Monosiga brevicollis
mouse-abhd4 Mus musculus (Mouse) abhydrolase domain-containing protein 4 similar to hypothetical protein flj12816 Mus musculus
mouse-abhd5 Mus musculus (Mouse) cgi-58 RIKEN AK004873 gene Mus musculus
nech7-c7z7d0 Nectria haematococca (strain 77-13-4 \/ FGSC 9596 \/ MPVI) (Fusarium solani subsp. pisi) Predicted protein Nectria haematococca
nemve-a7s6s7 Nematostella vectensis (Starlet sea anemone) Predicted protein Nematostella vectensis
nemve-a7sp35 Nematostella vectensis (Starlet sea anemone) Predicted protein Nematostella vectensis
neofi-a1d4m8 Neosartorya fischeri (strain ATCC 1020 \/ DSM 3700 \/ FGSC A1164 \/ NRR 181) (Aspergillus fischerianus) Alpha\/beta hydrolase, putative Neosartorya fischeri
neucr-NCU06332.1 Neurospora crassa hypothetical protein Neurospora crassa
orysa-Q0J0A4 Oryza sativa (japonica cultivar-group) cgi-58 protein-like Oryza sativa
parba-c1gny0 Paracoccidioides brasiliensis (strain ATCC MYA-826 \/ Pb01) Putative uncharacterized protein Paracoccidioides brasiliensis
parbp-c0sfj4 Paracoccidioides brasiliensis Abhydrolase domain-containing protein Paracoccidioides brasiliensis
pencw-b6h828 Penicillium chrysogenum (strain ATCC 28089 \/ DSM 1075 \/ Wisconsi 54-1255) (Penicillium notatum) Pc16g08280 protein Penicillium chrysogenum
penmq-b6qks8 Penicillium marneffei (strain ATCC 18224 \/ CBS 334.59 \/ QM 7333) Alpha\/beta hydrolase, putative Penicillium marneffei
phano-q0uq76 Phaeosphaeria nodorum (strain SN15 \/ FGSC 10173) (Glume blotch fungus) (Septoria nodorum) Putative uncharacterized protein Phaeosphaeria nodorum
phatc-b7g957 Phaeodactylum tricornutum (strain CCAP 1055\/1) Hydrolase Phaeodactylum tricornutum
phyit-d0mxu5 Phytophthora infestans (strain T30-4) (Potato late blight fungus) Cleavage induced serine protease family S33, putative Phytophthora infestans
phyit-d0nj53 Phytophthora infestans (strain T30-4) (Potato late blight fungus) Serine protease family S33, putative Phytophthora infestans
phyit-d0nj54 Phytophthora infestans (strain T30-4) (Potato late blight fungus) Serine protease family S33, putative Phytophthora infestans
phypa-a9sl58 Physcomitrella patens subsp. patens (Moss) Predicted protein Physcomitrella patens subsp. patens
picgu-a5dav0 Meyerozyma guilliermondii (strain ATCC 6260 \/ CBS 566 \/ DSM 6381 \/ JC 1539 \/ NBRC 10279 \/ NRRL Y-324) (Yeast) (Candida guilliermondii) Putative uncharacterized protein Meyerozyma guilliermondii
picgu-a5dev7 Meyerozyma guilliermondii (strain ATCC 6260 \/ CBS 566 \/ DSM 6381 \/ JC 1539 \/ NBRC 10279 \/ NRRL Y-324) (Yeast) (Candida guilliermondii) Putative uncharacterized protein Meyerozyma guilliermondii
picgu-a5dhe3 Meyerozyma guilliermondii (strain ATCC 6260 \/ CBS 566 \/ DSM 6381 \/ JC 1539 \/ NBRC 10279 \/ NRRL Y-324) (Yeast) (Candida guilliermondii) Putative uncharacterized protein Meyerozyma guilliermondii
picgu-a5di38 Meyerozyma guilliermondii (strain ATCC 6260 \/ CBS 566 \/ DSM 6381 \/ JC 1539 \/ NBRC 10279 \/ NRRL Y-324) (Yeast) (Candida guilliermondii) Putative uncharacterized protein Meyerozyma guilliermondii
picpg-c4r1s0 Pichia pastoris (strain GS115) (Yeast) Putative uncharacterized protein Pichia pastoris
picpg-c4r4a5 Pichia pastoris (strain GS115) (Yeast) Putative uncharacterized protein Pichia pastoris
picpg-c4r029 Pichia pastoris (strain GS115) (Yeast) Putative uncharacterized protein Pichia pastoris
picst-a3lnv8 Scheffersomyces stipitis (strain ATCC 58785 \/ CBS 6054 \/ NBRC 10063 NRRL Y-11545) (Yeast) (Pichia stipitis) Predicted protein Scheffersomyces stipitis
picst-a3lu11 Scheffersomyces stipitis (strain ATCC 58785 \/ CBS 6054 \/ NBRC 10063 NRRL Y-11545) (Yeast) (Pichia stipitis) Predicted protein Scheffersomyces stipitis
picst-a3luu0 Scheffersomyces stipitis (strain ATCC 58785 \/ CBS 6054 \/ NBRC 10063 \/ NRRL Y-11545) (Yeast) (Pichia stipitis) Predicted protein Scheffersomyces stipitis
picst-a3lwa4 Scheffersomyces stipitis (strain ATCC 58785 \/ CBS 6054 \/ NBRC 10063 NRRL Y-11545) (Yeast) (Pichia stipitis) Putative uncharacterized protein Scheffersomyces stipitis
podan-b2ase4 Podospora anserina (strain S \/ DSM 980 \/ FGSC 10383) (Pleuraga anserina) Predicted CDS Pa_1_23240 Podospora anserina
polpa-d3b7u3 Polysphondylium pallidum (Cellular slime mold) Putative uncharacterized protein Polysphondylium pallidum
ponab-abhd5 Pongo abelii (Sumatran orangutan) Pongo pygmaeus (Orangutan) Abhydrolase domain-containing protein 5 Pongo abelii
poptr-b9grg2 Populus trichocarpa (Western balsam poplar) (Populus balsamifera subsp. trichocarpa) Predicted protein Populus trichocarpa
poptr-b9h4j2 Populus trichocarpa (Western balsam poplar) (Populus balsamifera subsp. trichocarpa) AB hydrolase-1 domain-containing protein Populus trichocarpa
rat-d3zaw4 Rattus norvegicus (Rat) Uncharacterized protein Rattus norvegicus
ratno-abhd5 Rattus norvegicus (Rat) cgi-58-like protein Rattus norvegicus
ricco-b9r842 Ricinus communis (Castor bean) Abhydrolase domain containing, putative Ricinus communis
schjy-b6k6j0 Schizosaccharomyces japonicus (strain yFS275 \/ FY16936) (Fission yeast) Abhydrolase domain-containing protein Schizosaccharomyces japonicus
schpo-ye63 Schizosaccharomyces pombe (Fission yeast) hypothetical 48.7 kda protein c6g10.03c in chromosome i Schizosaccharomyces pombe
scls1-a7ewk9 Sclerotinia sclerotiorum (strain ATCC 18683 \/ 1980 \/ Ss-1) (White mold) (Whetzelinia sclerotiorum) Putative uncharacterized protein Sclerotinia sclerotiorum
sheep-a6ze98 Ovis aries (Sheep) Abhydrolase domain containing 5 Ovis aries
sorbi-c5x610 Sorghum bicolor (Sorghum) (Sorghum vulgare) Putative uncharacterized protein Sb02g030150 Sorghum bicolor
sormk-d1zcm2 Sordaria macrospora (strain ATCC MYA-333 \/ DSM 997 \/ K(L3346) K-hell) Whole genome shotgun sequence assembly, scaffold_17 Sordaria macrospora
soybn-c6tem2 Glycine max (Soybean) (Glycine hispida) Putative uncharacterized protein Glycine max
pig-abhd5 Sus scrofa (Pig) abhydrolase domain containing protein 5 Sus scrofa
talsn-b8mfi4 Talaromyces stipitatus (strain ATCC 10500 \/ CBS 375.48 \/ QM 6759 \/ NRRL 1006) (Penicillium stipitatum) Alpha\/beta hydrolase, putative Talaromyces stipitatus
tetng-q4snq3 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) hypothetical protein (fragment) Tetraodon nigroviridis
tetng-q4suu2 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) hypothetical protein (fragment) Tetraodon nigroviridis
tetts-a4veu1 Tetrahymena thermophila SB210 Putative uncharacterized protein Tetrahymena thermophila SB210
tetts-q22kh7 Tetrahymena thermophila SB210 hydrolase, alpha\/beta fold family protein Tetrahymena thermophila SB210
tetts-q23it6 Tetrahymena thermophila SB210 hydrolase, alpha\/beta fold family protein Tetrahymena thermophila SB210
tetts-q23l29 Tetrahymena thermophila SB210 hydrolase, alpha\/beta fold family protein Tetrahymena thermophila SB210
tetts-q23r77 Tetrahymena thermophila SB210 hydrolase, alpha\/beta fold family protein Tetrahymena thermophila SB210
tetts-q24h15 Tetrahymena thermophila SB210 hydrolase, alpha\/beta fold family protein Tetrahymena thermophila SB210
tetts-q230x1 Tetrahymena thermophila SB210 hydrolase, alpha\/beta fold family protein Tetrahymena thermophila SB210
tetts-q230x2 Tetrahymena thermophila SB210 hydrolase, alpha\/beta fold family protein Tetrahymena thermophila SB210
thaps-b8c954 Thalassiosira pseudonana (Marine diatom) Putative uncharacterized protein Thalassiosira pseudonana
thaps-b8cdd7 Thalassiosira pseudonana (Marine diatom) Putative uncharacterized protein Thalassiosira pseudonana
triad-b3rvc1 Trichoplax adhaerens (Trichoplax reptans) Putative uncharacterized protein Trichoplax adhaerens
tryb2-q581x1 Trypanosoma brucei hypothetical protein Trypanosoma brucei
uncre-c4jve9 Uncinocarpus reesii (strain UAMH 1704) Putative uncharacterized protein Uncinocarpus reesii
ustma-q4p0v2 Ustilago maydis (strain 521 \/ FGSC 9021) (Corn smut fungus) hypothetical protein Ustilago maydis 521
vanpo-a7thq3 Vanderwaltozyma polyspora (strain ATCC 22028 \/ DSM 70294) (Kluyveromyces polysporus) Putative uncharacterized protein Vanderwaltozyma polyspora
vanpo-a7tkh5 Vanderwaltozyma polyspora (strain ATCC 22028 \/ DSM 70294) (Kluyveromyces polysporus) Putative uncharacterized protein Vanderwaltozyma polyspora
vera1-c9s8d7 Verticillium albo-atrum (strain VaMs.102) (Verticillium wilt) Abhydrolase domain-containing protein Verticillium albo-atrum
xenla-q6dfc5 Xenopus laevis (African clawed frog) abhd5-prov protein Xenopus laevis
xentr-q5bki2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) hypothetical protein abhydrolase domain containing 5 Xenopus tropicalis
xentr-q28d58 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) abhydrolase domain containing 4 Xenopus tropicalis
yarli-q6c3h1 Yarrowia lipolytica (Candida lipolytica) similar to deha0f24211g debaryomyces hansenii ipf 6233.1 Yarrowia lipolytica
yarli-q6c8q4 Yarrowia lipolytica (Candida lipolytica) similar to sp|p53264 saccharomyces cerevisiae ygr110w Yarrowia lipolytica
yarli-q6ccr0 Yarrowia lipolytica (Candida lipolytica) lipolytica Yarrowia lipolytica
yeast-cld1 Saccharomyces cerevisiae (Baker's yeast) YGR110W hypothetical 52.0 kda protein in clb6-shy1 intergenic region Saccharomyces cerevisiae
yeast-ECM18 Saccharomyces cerevisiae (Baker's yeast) (and strains YJM789\; AWRI1631\; Lalvin EC1118 \/ Prise de mousse\; RM11-1a\; JAY291) hypothetical 53.2 kda extracellular matrix protein 18 Saccharomyces cerevisiae
yeast-ict1 Saccharomyces cerevisiae (Baker's yeast) chromosome XII reading frame orf ylr099c Increased copper tolerance protein 1 Saccharomyces cerevisiae
zygrc-c5dvh0 Zygosaccharomyces rouxii (strain ATCC 2623 \/ CBS 732 \/ NBRC 1130 NCYC 568 \/ NRRL Y-229) (Candida mogii) ZYRO0D06666p Zygosaccharomyces rouxii
9crus-a0a0p5zss0 Daphnia magna. 1-acylglycerol-3-phosphate O-acyltransferase ABHD5 Daphnia magna
trica-a0a139wfm6 Tribolium castaneum (Red flour beetle). 1-acylglycerol-3-phosphate O-acyltransferase ABHD5-like Protein Tribolium castaneum
attce-a0a158nft6 Atta cephalotes (Leafcutter ant). AB hydrolase-1 domain-containing protein ABHD5-like Atta cephalotes
papma-a0a194qw85 Papilio machaon (Old World swallowtail butterfly). Abhydrolase domain-containing protein 4 Papilio machaon
helvi-a0a2a4jzd0 Heliothis virescens (Tobacco budworm moth). AB hydrolase-1 domain-containing protein Heliothis virescens
galme-a0a6j1x1m4 Galleria mellonella (Greater wax moth). 1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform X3 Galleria mellonella
trini-a0a7e5wjd0 Trichoplusia ni (Cabbage looper). 1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform X2 Trichoplusia ni
cerca-a0a811un51 Ceratitis capitata (Mediterranean fruit fly) (Tephritis capitata). (Mediterranean fruit fly) ABHD5-like Ceratitis capitata
vesvu-a0a834jhn8 Vespula vulgaris (Yellow jacket) (Wasp). AB hydrolase-1 domain-containing protein Vespula vulgaris
tenmo-a0a8j6hh68 Tenebrio molitor (Yellow mealworm beetle). AB hydrolase-1 domain-containing protein Tenebrio molitor
parao-a0a8s3xp84 Parnassius apollo (Apollo butterfly) (Papilio apollo). (apollo) ABHD5-like Parnassius apollo
manse-a0a921zfz9 Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm). AB hydrolase-1 domain-containing protein Manduca sexta
spolt-a0a9j7ekq5 Spodoptera litura (Asian cotton leafworm). 1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform X2 Spodoptera litura
chril-a0a9n8l630 Chrysodeixis includens (Soybean looper) (Pseudoplusia includens). AB hydrolase-1 domain-containing protein Chrysodeixis includens
piebr-a0a9p0xbt8 Pieris brassicae (White butterfly) (Large white butterfly). AB hydrolase-1 domain-containing protein Pieris brassicae
piebr-a0a9p0xd27 Pieris brassicae (White butterfly) (Large white butterfly). AB hydrolase-1 domain-containing protein Pieris brassicae
trica-d6wua5 Tribolium castaneum (Red flour beetle). 1-acylglycerol-3-phosphate O-acyltransferase ABHD5-like Protein Tribolium castaneum
dappu-e9gj70 Daphnia pulex (Water flea). AB hydrolase-1 domain-containing protein Daphnia pulex

Gene_locus_frgt Name Species
brafl-c3yla8 Branchiostoma floridae (Florida lancelet) (Amphioxus) Putative uncharacterized protein Branchiostoma floridae
ixosc-b7qdz8 Ixodes scapularis (Black-legged tick) (Deer tick) Abhydrolase domain-containing protein, putative Ixodes scapularis
leibr-a4hcm8 Leishmania braziliensis Putative uncharacterized protein Leishmania braziliensis
leiin-a4i052 Leishmania infantum Putative uncharacterized protein Leishmania infantum
leima-L2581.02 Leishmania major possible acetyltransferase Leishmania major
micpc-c1msy5 Micromonas pusilla (strain CCMP1545) (Picoplanktonic green alga) Predicted protein Micromonas pusilla
pyrtr-b2w5g8 Pyrenophora tritici-repentis (strain Pt-1C-BFP) (Wheat tan spot fungus) (Drechslera tritici-repentis) Putative uncharacterized protein Pyrenophora tritici-repentis
schja-q5c3j8 Schistosoma japonicum (Blood fluke, platyhelminth) sjchgc09203 protein (fragment) Schistosoma japonicum
tetng-q4sip9 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) Chromosome 21 SCAF14577, whole genome shotgun sequence Tetraodon nigroviridis
trivh-d4d7r2 Trichophyton verrucosum (strain HKI 0517) Putative uncharacterized protein Trichophyton verrucosum

Substrate Chemical Nomenclature Proteins
Lyso-NAPE human-ABHD4
NAPE [(2R)-3-[hydroxy-[2-[[(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoyl]amino]ethoxy]phosphoryl]oxy-2-[(Z)-octadec-9-enoyl]oxypropyl] (Z)-octadec-9-enoate human-ABHD4
Dipalmitoylphosphatidylethanolamine [(2R)-3-[2-aminoethoxy(hydroxy)phosphoryl]oxy-2-hexadecanoyloxypropyl] hexadecanoate human-ABHD4

Inhibitor Chemical Nomenclature Proteins
ABC47 [1,3-dioxo-7-[(4-phenoxyphenyl)methyl]-5,6,8,8a-tetrahydroimidazo[1,5-a]pyrazin-2-yl] 4-phenylpiperidine-1-carboxylate human-ABHD3    human-ABHD4
ABC51 [1,3-dioxo-7-[(4-phenoxyphenyl)methyl]-5,6,8,8a-tetrahydroimidazo[1,5-a]pyrazin-2-yl] morpholine-4-carboxylate human-ABHD4
SR-3420 1-[3-[3,5-bis(trifluoromethyl)phenyl]propyl]-3-(5-methyl-6-oxobenzo[b][1,4]benzothiazepin-3-yl)urea human-ABHD5    mouse-abhd5
SR-4995 1-butyl-3-(5-methyl-6-oxobenzo[b][1,4]benzothiazepin-3-yl)urea human-ABHD5    mouse-abhd5
SR-3133 1-[4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)piperazin-1-yl]-2-(3-fluorophenyl)ethanone human-ABHD5    mouse-abhd5
SR-3134 1-[4-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylsulfonyl)piperazin-1-yl]-2-(4-methoxyphenyl)ethanone human-ABHD5    mouse-abhd5
SR-4559 1-[4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)piperazin-1-yl]-2-(6-methyl-1-benzofuran-3-yl)ethanone human-ABHD5    mouse-abhd5
ABP-C6 Hexyl 4-nitrophenyl (3-azidopropyl)phosphonate mouse-hslip    mouse-MGLL    mouse-Abhd11    mouse-Ces1d    mouse-ES10    mouse-lypla2    drome-CG18815    mouse-lypla1    mouse-Ces1c    mouse-Ces1f    mouse-Ces1g    mouse-PPME1    mouse-apeh    mouse-abhd5    mouse-lypl1    mouse-Ces2c    mouse-Ces2a    mouse-Ces2e    mouse-aryla    mouse-BCHE    mouse-dpp2    mouse-dpp4    mouse-C87498
NBD-HE-HP N-[2-[hexyl-(4-nitrophenoxy)phosphoryl]oxyethyl]-6-[(4-nitro-2,1,3-benzoxadiazol-7-yl)amino]hexanamide mouse-hslip    mouse-Ces1d    mouse-MGLL    mouse-ES10    mouse-Abhd11    drome-CG2059    mouse-lypla2    drome-CG18815    mouse-lypla1    mouse-Ces1c    mouse-Ces1f    mouse-PPME1    mouse-apeh    mouse-abhd5    drome-CG1882    mouse-lypl1    burce-lipaa    rhidl-lipas    drome-EST23aes07    drome-este6    drome-CG5355    drome-aes05    drome-aes02    drome-CG8425
Methyl-arachidonyl-fluorophosphonate (5Z,8Z,11Z,14Z)-1-[fluoro(methoxy)phosphoryl]icosa-5,8,11,14-tetraene human-PLA2G15    9eury-6QE2    human-ABHD4

References (73)

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Gene_locus related to this paper: human-ABHD5 , mouse-abhd5

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Gene_locus related to this paper: human-ABHD5

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Gene_locus related to this paper: human-ABHD5

Title : ABHD4 regulates adipocyte differentiation in vitro but does not affect adipose tissue lipid metabolism in mice - Seramur_2023_J.Lipid.Res__100405
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Gene_locus related to this paper: human-ABHD4 , mouse-abhd4

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Gene_locus related to this paper: human-ABHD5 , mouse-abhd5

Title : Improved Stability of Human CGI-58 Induced by Phosphomimetic S237E Mutation - Llamas-Garcia_2022_ACS.Omega_7_12643
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Gene_locus related to this paper: human-ABHD5

Title : Structural and functional insights into ABHD5, a ligand-regulated lipase co-activator - Tseng_2022_Sci.Rep_12_2565
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Gene_locus related to this paper: human-ABHD5

Title : Aging reduces ABHD5 protein content in the adipose tissue of mice: The reversal effect of exercise - Bricola_2022_Cell.Biochem.Funct__
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Ref : Cell Biochemistry & Function , : , 2022
Abstract :
PubMedSearch : Bricola_2022_Cell.Biochem.Funct__
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Gene_locus related to this paper: human-ABHD5 , mouse-abhd5

Title : Human CIDEC transgene improves lipid metabolism and protects against high-fat diet-induced glucose intolerance in mice - Gupta_2022_J.Biol.Chem__
Author(s) : Gupta A , Balakrishnan B , Karki S , Slayton M , Jash S , Banerjee S , Grahn THM , Jambunathan S , Disney S , Hussein H , Kong D , Lowell BB , Natarajan P , Reddy UK , Gokce N , Sharma VM , Puri V
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Abstract :
PubMedSearch : Gupta_2022_J.Biol.Chem__
PubMedID: 35963433
Gene_locus related to this paper: human-ABHD5

Title : Cardiac-specific CGI-58 deficiency activates the ER stress pathway to promote heart failure in mice - Xie_2021_Cell.Death.Dis_12_1003
Author(s) : Xie X , Tie YF , Lai S , Zhang YL , Li HH , Liu Y
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Abstract :
PubMedSearch : Xie_2021_Cell.Death.Dis_12_1003
PubMedID: 34702801

Title : ABHD4-Regulating RNA Panel: Novel Biomarkers in Acute Coronary Syndrome Diagnosis - Agwa_2021_Cells_10_
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Ref : Cells , 10 : , 2021
Abstract :
PubMedSearch : Agwa_2021_Cells_10_
PubMedID: 34208452
Gene_locus related to this paper: human-ABHD4

Title : CGI-58: Versatile Regulator of Intracellular Lipid Droplet Homeostasis - Yu_2020_Adv.Exp.Med.Biol_1276_197
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Ref : Advances in Experimental Medicine & Biology , 1276 :197 , 2020
Abstract :
PubMedSearch : Yu_2020_Adv.Exp.Med.Biol_1276_197
PubMedID: 32705602
Gene_locus related to this paper: human-ABHD5

Title : Western diet induces severe nonalcoholic steatohepatitis, ductular reaction, and hepatic fibrosis in liver CGI-58 knockout mice - Yang_2020_Sci.Rep_10_4701
Author(s) : Yang P , Wang Y , Tang W , Sun W , Ma Y , Lin S , Jing J , Jiang L , Shi H , Song Z , Yu L
Ref : Sci Rep , 10 :4701 , 2020
Abstract :
PubMedSearch : Yang_2020_Sci.Rep_10_4701
PubMedID: 32170127
Gene_locus related to this paper: human-ABHD5 , mouse-abhd5

Title : ABHD5 suppresses cancer cell anabolism through lipolysis-dependent activation of the AMPK\/mTORC1 pathway - Chen_2020_J.Biol.Chem_296_100104
Author(s) : Chen G , Zhou G , Lotvola A , Granneman JG , Wang J
Ref : Journal of Biological Chemistry , 296 :100104 , 2020
Abstract :
PubMedSearch : Chen_2020_J.Biol.Chem_296_100104
PubMedID: 33219129
Gene_locus related to this paper: human-ABHD5

Title : ABHD4-dependent developmental anoikis safeguards the embryonic brain - Laszlo_2020_Nat.Commun_11_4363
Author(s) : Laszlo ZI , Lele Z , Zoldi M , Miczan V , Mogor F , Simon GM , Mackie K , Kacskovics I , Cravatt BF , Katona I
Ref : Nat Commun , 11 :4363 , 2020
Abstract :
PubMedSearch : Laszlo_2020_Nat.Commun_11_4363
PubMedID: 32868797
Gene_locus related to this paper: human-ABHD4 , mouse-abhd4

Title : The lipid droplet-associated protein ABHD5 protects the heart through proteolysis of HDAC4 - Jebessa_2019_Nat.Metab_1_1157
Author(s) : Jebessa ZH , Shanmukha Kumar D , Dewenter M , Lehmann LH , Xu C , Schreiter F , Siede D , Gong XM , Worst BC , Federico G , Sauer SW , Fischer T , Wechselberger L , Muller OJ , Sossalla S , Dieterich C , Most P , Grone HJ , Moro C , Oberer M , Haemmerle G , Katus HA , Tyedmers J , Backs J
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Abstract :
PubMedSearch : Jebessa_2019_Nat.Metab_1_1157
PubMedID: 31742248
Gene_locus related to this paper: human-ABHD5

Title : Dynamic interactions of ABHD5 with PNPLA3 regulate triacylglycerol metabolism in brown adipocytes - Yang_2019_Nat.Metab_1_560
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Abstract :
PubMedSearch : Yang_2019_Nat.Metab_1_560
PubMedID: 31497752
Gene_locus related to this paper: human-ABHD5

Title : The alpha\/beta-hydrolase domain-containing 4- and 5-related phospholipase Pummelig controls energy storage in Drosophila - Hehlert_2019_J.Lipid.Res_60_1365
Author(s) : Hehlert P , Hofferek V , Heier C , Eichmann TO , Riedel D , Rosenberg J , Takacs A , Nagy HM , Oberer M , Zimmermann R , Kuhnlein RP
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Abstract :
PubMedSearch : Hehlert_2019_J.Lipid.Res_60_1365
PubMedID: 31164391
Gene_locus related to this paper: drome-CG1882

Title : Macrophage ABHD5 Suppresses NFkappaB-Dependent Matrix Metalloproteinase Expression and Cancer Metastasis - Shang_2019_Cancer.Res_79_5513
Author(s) : Shang S , Ji X , Zhang L , Chen J , Li C , Shi R , Xiang W , Kang X , Zhang D , Yang F , Dai R , Chen P , Chen S , Chen Y , Li Y , Miao H
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Abstract :
PubMedSearch : Shang_2019_Cancer.Res_79_5513
PubMedID: 31439546
Gene_locus related to this paper: human-ABHD5

Title : Oncogenic role of ABHD5 in endometrial cancer - Zhou_2019_Cancer.Manag.Res_11_2139
Author(s) : Zhou Q , Wang F , Zhou K , Huang K , Zhu Q , Luo X , Yu J , Shi Z
Ref : Cancer Manag Res , 11 :2139 , 2019
Abstract :
PubMedSearch : Zhou_2019_Cancer.Manag.Res_11_2139
PubMedID: 30936746
Gene_locus related to this paper: human-ABHD5

Title : ABHD5 stimulates PNPLA1-mediated omega-O-acylceramide biosynthesis essential for a functional skin permeability barrier - Kien_2018_J.Lipid.Res_59_2360
Author(s) : Kien B , Grond S , Haemmerle G , Lass A , Eichmann TO , Radner FPW
Ref : J Lipid Res , 59 :2360 , 2018
Abstract :
PubMedSearch : Kien_2018_J.Lipid.Res_59_2360
PubMedID: 30361410
Gene_locus related to this paper: human-ABHD5

Title : The Expression Pattern of PLIN2 in Differentiated Adipocytes from Qinchuan Cattle Analysis of Its Protein Structure and Interaction with CGI-58 - Li_2018_Int.J.Mol.Sci_19_
Author(s) : Li P , Wang Y , Zhang L , Ning Y , Zan L
Ref : Int J Mol Sci , 19 : , 2018
Abstract :
PubMedSearch : Li_2018_Int.J.Mol.Sci_19_
PubMedID: 29723991

Title : Critical roles for alpha\/beta hydrolase domain 5 (ABHD5)\/comparative gene identification-58 (CGI-58) at the lipid droplet interface and beyond - Brown_2017_Biochim.Biophys.Acta_1862_1233
Author(s) : Brown AL , Mark Brown J
Ref : Biochimica & Biophysica Acta , 1862 :1233 , 2017
Abstract :
PubMedSearch : Brown_2017_Biochim.Biophys.Acta_1862_1233
PubMedID: 28827091
Gene_locus related to this paper: human-ABHD5

Title : Molecular Basis of ABHD5 Lipolysis Activation - Sanders_2017_Sci.Rep_7_42589
Author(s) : Sanders MA , Zhang H , Mladenovic L , Tseng YY , Granneman JG
Ref : Sci Rep , 7 :42589 , 2017
Abstract :
PubMedSearch : Sanders_2017_Sci.Rep_7_42589
PubMedID: 28211464
Gene_locus related to this paper: mouse-abhd4 , mouse-abhd5

Title : Lipolysis in Brown Adipocytes Is Not Essential for Cold-Induced Thermogenesis in Mice - Shin_2017_Cell.Metab_26_764
Author(s) : Shin H , Ma Y , Chanturiya T , Cao Q , Wang Y , Kadegowda AKG , Jackson R , Rumore D , Xue B , Shi H , Gavrilova O , Yu L
Ref : Cell Metab , 26 :764 , 2017
Abstract :
PubMedSearch : Shin_2017_Cell.Metab_26_764
PubMedID: 28988822

Title : Macrophage ABHD5 promotes colorectal cancer growth by suppressing spermidine production by SRM - Miao_2016_Nat.Commun_7_11716
Author(s) : Miao H , Ou J , Peng Y , Zhang X , Chen Y , Hao L , Xie G , Wang Z , Pang X , Ruan Z , Li J , Yu L , Xue B , Shi H , Shi C , Liang H
Ref : Nat Commun , 7 :11716 , 2016
Abstract :
PubMedSearch : Miao_2016_Nat.Commun_7_11716
PubMedID: 27189574

Title : CGI-58\/ABHD5 is phosphorylated on Ser239 by protein kinase A: control of subcellular localization - Sahu-Osen_2015_J.Lipid.Res_56_109
Author(s) : Sahu-Osen A , Montero-Moran G , Schittmayer M , Fritz K , Dinh A , Chang YF , McMahon D , Boeszoermenyi A , Cornaciu I , Russell D , Oberer M , Carman GM , Birner-Gruenberger R , Brasaemle DL
Ref : J Lipid Res , 56 :109 , 2015
Abstract :
PubMedSearch : Sahu-Osen_2015_J.Lipid.Res_56_109
PubMedID: 25421061
Gene_locus related to this paper: human-ABHD5

Title : The Causative Gene in Chanaran Dorfman Syndrome Regulates Lipid Droplet Homeostasis in C. elegans - Xie_2015_PLoS.Genet_11_e1005284
Author(s) : Xie M , Roy R
Ref : PLoS Genet , 11 :e1005284 , 2015
Abstract :
PubMedSearch : Xie_2015_PLoS.Genet_11_e1005284
PubMedID: 26083785
Gene_locus related to this paper: caeel-C37H5.2 , caeel-C37H5.3

Title : ABHD4 regulates multiple classes of N-acyl phospholipids in the mammalian central nervous system - Lee_2015_Biochemistry_54_2539
Author(s) : Lee HC , Simon GM , Cravatt BF
Ref : Biochemistry , 54 :2539 , 2015
Abstract :
PubMedSearch : Lee_2015_Biochemistry_54_2539
PubMedID: 25853435
Gene_locus related to this paper: human-ABHD4

Title : Comparative gene identification 58\/alpha\/beta hydrolase domain 5 lacks lysophosphatidic acid acyltransferase activity - McMahon_2014_J.Lipid.Res_55_1750
Author(s) : McMahon D , Dinh A , Kurz D , Shah D , Han GS , Carman GM , Brasaemle DL
Ref : J Lipid Res , 55 :1750 , 2014
Abstract :
PubMedSearch : McMahon_2014_J.Lipid.Res_55_1750
PubMedID: 24879803
Gene_locus related to this paper: human-ABHD5

Title : Comparative gene identification-58 (CGI-58) promotes autophagy as a putative lysophosphatidylglycerol acyltransferase - Zhang_2014_J.Biol.Chem_289_33044
Author(s) : Zhang J , Xu D , Nie J , Han R , Zhai Y , Shi Y
Ref : Journal of Biological Chemistry , 289 :33044 , 2014
Abstract :
PubMedSearch : Zhang_2014_J.Biol.Chem_289_33044
PubMedID: 25315780
Gene_locus related to this paper: human-ABHD5

Title : The important role of epidermal triacylglycerol metabolism for maintenance of the skin permeability barrier function - Radner_2014_Biochim.Biophys.Acta_1841_409
Author(s) : Radner FP , Fischer J
Ref : Biochimica & Biophysica Acta , 1841 :409 , 2014
Abstract :
PubMedSearch : Radner_2014_Biochim.Biophys.Acta_1841_409
PubMedID: 23928127

Title : The alpha\/beta hydrolase CGI-58 and peroxisomal transport protein PXA1 Coregulate lipid homeostasis and signaling in Arabidopsis - Park_2013_Plant.Cell_25_1726
Author(s) : Park S , Gidda SK , James CN , Horn PJ , Khuu N , Seay DC , Keereetaweep J , Chapman KD , Mullen RT , Dyer JM
Ref : Plant Cell , 25 :1726 , 2013
Abstract :
PubMedSearch : Park_2013_Plant.Cell_25_1726
PubMedID: 23667126
Gene_locus related to this paper: arath-LPAAT

Title : Distinct roles for alpha-beta hydrolase domain 5 (ABHD5\/CGI-58) and adipose triglyceride lipase (ATGL\/PNPLA2) in lipid metabolism and signaling - Lord_2012_Adipocyte_1_123
Author(s) : Lord CC , Brown JM
Ref : Adipocyte , 1 :123 , 2012
Abstract :
PubMedSearch : Lord_2012_Adipocyte_1_123
PubMedID: 23145367
Gene_locus related to this paper: human-ABHD5

Title : CGI-58\/ABHD5-derived signaling lipids regulate systemic inflammation and insulin action - Lord_2012_Diabetes_61_355
Author(s) : Lord CC , Betters JL , Ivanova PT , Milne SB , Myers DS , Madenspacher J , Thomas G , Chung S , Liu M , Davis MA , Lee RG , Crooke RM , Graham MJ , Parks JS , Brasaemle DL , Fessler MB , Brown HA , Brown JM
Ref : Diabetes , 61 :355 , 2012
Abstract :
PubMedSearch : Lord_2012_Diabetes_61_355
PubMedID: 22228714
Gene_locus related to this paper: human-ABHD5

Title : Recent insights into the structure and function of comparative gene identification-58 - Oberer_2011_Curr.Opin.Lipidol_22_149
Author(s) : Oberer M , Boeszoermenyi A , Nagy HM , Zechner R
Ref : Curr Opin Lipidol , 22 :149 , 2011
Abstract :
PubMedSearch : Oberer_2011_Curr.Opin.Lipidol_22_149
PubMedID: 21494142
Gene_locus related to this paper: human-ABHD5

Title : Differential control of ATGL-mediated lipid droplet degradation by CGI-58 and G0S2 - Lu_2010_Cell.Cycle_9_2719
Author(s) : Lu X , Yang X , Liu J
Ref : Cell Cycle , 9 :2719 , 2010
Abstract :
PubMedSearch : Lu_2010_Cell.Cycle_9_2719
PubMedID: 20676045

Title : Disruption of the Arabidopsis CGI-58 homologue produces Chanarin-Dorfman-like lipid droplet accumulation in plants - James_2010_Proc.Natl.Acad.Sci.U.S.A_107_17833
Author(s) : James CN , Horn PJ , Case CR , Gidda SK , Zhang D , Mullen RT , Dyer JM , Anderson RG , Chapman KD
Ref : Proc Natl Acad Sci U S A , 107 :17833 , 2010
Abstract :
PubMedSearch : James_2010_Proc.Natl.Acad.Sci.U.S.A_107_17833
PubMedID: 20876112
Gene_locus related to this paper: arath-LPAAT

Title : Crucial role of CGI-58\/alpha\/beta hydrolase domain-containing protein 5 in lipid metabolism - Yamaguchi_2010_Biol.Pharm.Bull_33_342
Author(s) : Yamaguchi T
Ref : Biol Pharm Bull , 33 :342 , 2010
Abstract :
PubMedSearch : Yamaguchi_2010_Biol.Pharm.Bull_33_342
PubMedID: 20190389

Title : CGI-58 knockdown in mice causes hepatic steatosis but prevents diet-induced obesity and glucose intolerance - Brown_2010_J.Lipid.Res_51_3306
Author(s) : Brown JM , Betters JL , Lord C , Ma Y , Han X , Yang K , Alger HM , Melchior J , Sawyer J , Shah R , Wilson MD , Liu X , Graham MJ , Lee R , Crooke R , Shulman GI , Xue B , Shi H , Yu L
Ref : J Lipid Res , 51 :3306 , 2010
Abstract :
PubMedSearch : Brown_2010_J.Lipid.Res_51_3306
PubMedID: 20802159
Gene_locus related to this paper: human-ABHD5 , mouse-abhd5

Title : The N-terminal region of comparative gene identification-58 (CGI-58) is important for lipid droplet binding and activation of adipose triglyceride lipase - Gruber_2010_J.Biol.Chem_285_12289
Author(s) : Gruber A , Cornaciu I , Lass A , Schweiger M , Poeschl M , Eder C , Kumari M , Schoiswohl G , Wolinski H , Kohlwein SD , Zechner R , Zimmermann R , Oberer M
Ref : Journal of Biological Chemistry , 285 :12289 , 2010
Abstract :
PubMedSearch : Gruber_2010_J.Biol.Chem_285_12289
PubMedID: 20164531

Title : Growth retardation, impaired triacylglycerol catabolism, hepatic steatosis, and lethal skin barrier defect in mice lacking comparative gene identification-58 (CGI-58) - Radner_2010_J.Biol.Chem_285_7300
Author(s) : Radner FP , Streith IE , Schoiswohl G , Schweiger M , Kumari M , Eichmann TO , Rechberger G , Koefeler HC , Eder S , Schauer S , Theussl HC , Preiss-Landl K , Lass A , Zimmermann R , Hoefler G , Zechner R , Haemmerle G
Ref : Journal of Biological Chemistry , 285 :7300 , 2010
Abstract :
PubMedSearch : Radner_2010_J.Biol.Chem_285_7300
PubMedID: 20023287
Gene_locus related to this paper: mouse-abhd5

Title : Identification of a novel splicing isoform of murine CGI-58 - Yang_2010_FEBS.Lett_584_903
Author(s) : Yang X , Lu X , Liu J
Ref : FEBS Letters , 584 :903 , 2010
Abstract :
PubMedSearch : Yang_2010_FEBS.Lett_584_903
PubMedID: 20083112
Gene_locus related to this paper: mouse-abhd5

Title : CGI-58\/ABHD5 is a coenzyme A-dependent lysophosphatidic acid acyltransferase - Montero-Moran_2010_J.Lipid.Res_51_709
Author(s) : Montero-Moran G , Caviglia JM , McMahon D , Rothenberg A , Subramanian V , Xu Z , Lara-Gonzalez S , Storch J , Carman GM , Brasaemle DL
Ref : J Lipid Res , 51 :709 , 2010
Abstract :
PubMedSearch : Montero-Moran_2010_J.Lipid.Res_51_709
PubMedID: 19801371

Title : Chanarin-Dorfman syndrome: deficiency in CGI-58, a lipid droplet-bound coactivator of lipase - Yamaguchi_2009_Biochim.Biophys.Acta_1791_519
Author(s) : Yamaguchi T , Osumi T
Ref : Biochimica & Biophysica Acta , 1791 :519 , 2009
Abstract :
PubMedSearch : Yamaguchi_2009_Biochim.Biophys.Acta_1791_519
PubMedID: 19061969
Gene_locus related to this paper: human-ABHD5

Title : Neutral lipid storage disease: genetic disorders caused by mutations in adipose triglyceride lipase\/PNPLA2 or CGI-58\/ABHD5 - Schweiger_2009_Am.J.Physiol.Endocrinol.Metab_297_E289
Author(s) : Schweiger M , Lass A , Zimmermann R , Eichmann TO , Zechner R
Ref : American Journal of Physiology Endocrinol Metab , 297 :E289 , 2009
Abstract :
PubMedSearch : Schweiger_2009_Am.J.Physiol.Endocrinol.Metab_297_E289
PubMedID: 19401457
Gene_locus related to this paper: human-ABHD5

Title : ABHD5\/CGI-58 facilitates the assembly and secretion of apolipoprotein B lipoproteins by McA RH7777 rat hepatoma cells - Caviglia_2009_Biochim.Biophys.Acta_1791_198
Author(s) : Caviglia JM , Sparks JD , Toraskar N , Brinker AM , Yin TC , Dixon JL , Brasaemle DL
Ref : Biochimica & Biophysica Acta , 1791 :198 , 2009
Abstract :
PubMedSearch : Caviglia_2009_Biochim.Biophys.Acta_1791_198
PubMedID: 19211039

Title : CGI-58 is an alpha\/beta-hydrolase within lipid transporting lamellar granules of differentiated keratinocytes - Akiyama_2008_Am.J.Pathol_173_1349
Author(s) : Akiyama M , Sakai K , Takayama C , Yanagi T , Yamanaka Y , McMillan JR , Shimizu H
Ref : American Journal of Pathology , 173 :1349 , 2008
Abstract :
PubMedSearch : Akiyama_2008_Am.J.Pathol_173_1349
PubMedID: 18832586

Title : CGI-58, the causative gene for Chanarin-Dorfman syndrome, mediates acylation of lysophosphatidic acid - Ghosh_2008_J.Biol.Chem_283_24525
Author(s) : Ghosh AK , Ramakrishnan G , Chandramohan C , Rajasekharan R
Ref : Journal of Biological Chemistry , 283 :24525 , 2008
Abstract :
PubMedSearch : Ghosh_2008_J.Biol.Chem_283_24525
PubMedID: 18606822
Gene_locus related to this paper: human-ABHD5

Title : Reduced hepatic expression of adipose tissue triglyceride lipase and CGI-58 may contribute to the development of non-alcoholic fatty liver disease in patients with insulin resistance -
Author(s) : Kato M , Higuchi N , Enjoji M
Ref : Scand J Gastroenterol , 43 :1018 , 2008
PubMedID: 19086170

Title : CGI-58 facilitates the mobilization of cytoplasmic triglyceride for lipoprotein secretion in hepatoma cells - Brown_2007_J.Lipid.Res_48_2295
Author(s) : Brown JM , Chung S , Das A , Shelness GS , Rudel LL , Yu L
Ref : J Lipid Res , 48 :2295 , 2007
Abstract :
PubMedSearch : Brown_2007_J.Lipid.Res_48_2295
PubMedID: 17664529

Title : CGI-58 facilitates lipolysis on lipid droplets but is not involved in the vesiculation of lipid droplets caused by hormonal stimulation - Yamaguchi_2007_J.Lipid.Res_48_1078
Author(s) : Yamaguchi T , Omatsu N , Morimoto E , Nakashima H , Ueno K , Tanaka T , Satouchi K , Hirose F , Osumi T
Ref : J Lipid Res , 48 :1078 , 2007
Abstract :
PubMedSearch : Yamaguchi_2007_J.Lipid.Res_48_1078
PubMedID: 17308334

Title : A novel S115G mutation of CGI-58 in a Turkish patient with Dorfman-Chanarin syndrome -
Author(s) : Ben Selma Z , Yilmaz S , Schischmanoff PO , Blom A , Ozogul C , Laroche L , Caux F
Ref : Journal of Investigative Dermatology , 127 :2273 , 2007
PubMedID: 17495960
Gene_locus related to this paper: human-ABHD5

Title : Severe oily ichthyosis in monozygotic twins mimicking Chanarin-Dorfman syndrome but not associated with a mutation of the CGI58 gene -
Author(s) : Solomon C , Bernier L , Germain L , Dufour R , Davignon J
Ref : Arch Dermatol , 142 :402 , 2006
PubMedID: 16549731
Gene_locus related to this paper: human-ABHD5

Title : Fat breakdown: a function for CGI-58 (ABHD5) provides a new piece of the puzzle - Yen_2006_Cell.Metab_3_305
Author(s) : Yen CL , Farese RV, Jr.
Ref : Cell Metab , 3 :305 , 2006
Abstract :
PubMedSearch : Yen_2006_Cell.Metab_3_305
PubMedID: 16679288
Gene_locus related to this paper: human-ABHD5

Title : Adipose triglyceride lipase-mediated lipolysis of cellular fat stores is activated by CGI-58 and defective in Chanarin-Dorfman Syndrome - Lass_2006_Cell.Metab_3_309
Author(s) : Lass A , Zimmermann R , Haemmerle G , Riederer M , Schoiswohl G , Schweiger M , Kienesberger P , Strauss JG , Gorkiewicz G , Zechner R
Ref : Cell Metab , 3 :309 , 2006
Abstract :
PubMedSearch : Lass_2006_Cell.Metab_3_309
PubMedID: 16679289
Gene_locus related to this paper: human-ABHD5

Title : Two new mutations of the ABHD5 gene in a new adult case of Chanarin Dorfman syndrome: an uncommon lipid storage disease -
Author(s) : Schleinitz N , Fischer J , Sanchez A , Veit V , Harle JR , Pelissier JF
Ref : Arch Dermatol , 141 :798 , 2005
PubMedID: 15967942
Gene_locus related to this paper: human-ABHD5

Title : Erythrokeratoderma variabilis-like ichthyosis in Chanarin-Dorfman syndrome - Pujol_2005_Br.J.Dermatol_153_838
Author(s) : Pujol RM , Gilaberte M , Toll A , Florensa L , Lloreta J , Gonzalez-Ensenat MA , Fischer J , Azon A
Ref : Br J Dermatol , 153 :838 , 2005
Abstract :
PubMedSearch : Pujol_2005_Br.J.Dermatol_153_838
PubMedID: 16181472
Gene_locus related to this paper: human-ABHD5

Title : CGI-58\/ABHD5 gene is mutated in Dorfman-Chanarin syndrome -
Author(s) : Caux F , Selma ZB , Laroche L , Prud'homme JF , Fischer J
Ref : American Journal of Medicine Genet A , 129A :214 , 2004
PubMedID: 15316960
Gene_locus related to this paper: human-ABHD5

Title : CGI-58 interacts with perilipin and is localized to lipid droplets. Possible involvement of CGI-58 mislocalization in Chanarin-Dorfman syndrome - Yamaguchi_2004_J.Biol.Chem_279_30490
Author(s) : Yamaguchi T , Omatsu N , Matsushita S , Osumi T
Ref : Journal of Biological Chemistry , 279 :30490 , 2004
Abstract :
PubMedSearch : Yamaguchi_2004_J.Biol.Chem_279_30490
PubMedID: 15136565
Gene_locus related to this paper: ratno-abhd5 , human-ABHD5

Title : Steatohepatitis and unsuspected micronodular cirrhosis in Dorfman-Chanarin syndrome with documented ABHD5 mutation - Srinivasan_2004_J.Pediatr_144_662
Author(s) : Srinivasan R , Hadzic N , Fischer J , Knisely AS
Ref : J Pediatr , 144 :662 , 2004
Abstract :
PubMedSearch : Srinivasan_2004_J.Pediatr_144_662
PubMedID: 15127008
Gene_locus related to this paper: human-ABHD5

Title : Perilipin A mediates the reversible binding of CGI-58 to lipid droplets in 3T3-L1 adipocytes - Subramanian_2004_J.Biol.Chem_279_42062
Author(s) : Subramanian V , Rothenberg A , Gomez C , Cohen AW , Garcia A , Bhattacharyya S , Shapiro L , Dolios G , Wang R , Lisanti MP , Brasaemle DL
Ref : Journal of Biological Chemistry , 279 :42062 , 2004
Abstract :
PubMedSearch : Subramanian_2004_J.Biol.Chem_279_42062
PubMedID: 15292255
Gene_locus related to this paper: mouse-abhd5

Title : Truncation of CGI-58 protein causes malformation of lamellar granules resulting in ichthyosis in Dorfman-Chanarin syndrome - Akiyama_2003_J.Invest.Dermatol_121_1029
Author(s) : Akiyama M , Sawamura D , Nomura Y , Sugawara M , Shimizu H
Ref : Journal of Investigative Dermatology , 121 :1029 , 2003
Abstract :
PubMedSearch : Akiyama_2003_J.Invest.Dermatol_121_1029
PubMedID: 14708602
Gene_locus related to this paper: human-ABHD5

Title : Dorfman--Chanarin syndrome (neutral lipid storage disease): new clinical features -
Author(s) : Pena-Penabad C , Almagro M , Martinez W , Garcia-Silva J , Del Pozo J , Yebra MT , Sanchez-Manzano C , Fonseca E
Ref : Br J Dermatol , 144 :430 , 2001
PubMedID: 11251597

Title : Mutations in CGI-58, the gene encoding a new protein of the esterase\/lipase\/thioesterase subfamily, in Chanarin-Dorfman syndrome - Lefevre_2001_Am.J.Hum.Genet_69_1002
Author(s) : Lefevre C , Jobard F , Caux F , Bouadjar B , Karaduman A , Heilig R , Lakhdar H , Wollenberg A , Verret JL , Weissenbach J , Ozguc M , Lathrop M , Prud'homme JF , Fischer J
Ref : American Journal of Human Genetics , 69 :1002 , 2001
Abstract :
PubMedSearch : Lefevre_2001_Am.J.Hum.Genet_69_1002
PubMedID: 11590543
Gene_locus related to this paper: human-ABHD5

Title : Dorfman-Chanarin syndrome: a rare neutral lipid storage disease -
Author(s) : Tullu MS , Muranjan MN , Save SU , Deshmukh CT , Khubchandani SR , Bharucha BA
Ref : Indian Pediatr , 37 :88 , 2000
PubMedID: 10745395

Title : [Dorfman-Chanarin syndrome] - Kaassis_1998_Ann.Dermatol.Venereol_125_317
Author(s) : Kaassis C , Ginies JL , Berthelot J , Verret JL
Ref : Ann Dermatol Venereol , 125 :317 , 1998
Abstract :
PubMedSearch : Kaassis_1998_Ann.Dermatol.Venereol_125_317
PubMedID: 9747278

Title : [Dorfman-Chanarin syndrome--a neutral lipid storage disease] - Wollenberg_1997_Hautarzt_48_753
Author(s) : Wollenberg A , Schaller M , Roschinger W , Schirren CG , Wolff H
Ref : Hautarzt , 48 :753 , 1997
Abstract :
PubMedSearch : Wollenberg_1997_Hautarzt_48_753
PubMedID: 9441170

Title : Dorfman-Chanarin syndrome: a case with prevalent hepatic involvement - Mela_1996_J.Hepatol_25_769
Author(s) : Mela D , Artom A , Goretti R , Varagona G , Riolfo M , Ardoino S , Sanguineti G , Vitali A , Ricciardi S
Ref : Journal of Hepatology , 25 :769 , 1996
Abstract :
PubMedSearch : Mela_1996_J.Hepatol_25_769
PubMedID: 8938558

Title : Neutral lipid storage disease: a possible functional defect in phospholipid- linked triacylglycerol metabolism - Williams_1991_Biochim.Biophys.Acta_1096_162
Author(s) : Williams ML , Coleman RA , Placezk D , Grunfeld C
Ref : Biochimica & Biophysica Acta , 1096 :162 , 1991
Abstract :
PubMedSearch : Williams_1991_Biochim.Biophys.Acta_1096_162
PubMedID: 2001430

Title : Neutral lipid storage disease with ichthyosis. Defective lamellar body contents and intracellular dispersion - Elias_1985_Arch.Dermatol_121_1000
Author(s) : Elias PM , Williams ML
Ref : Arch Dermatol , 121 :1000 , 1985
Abstract :
PubMedSearch : Elias_1985_Arch.Dermatol_121_1000
PubMedID: 4026335

Title : Neutral-lipid storage disease: a new disorder of lipid metabolism -
Author(s) : Chanarin I , Patel A , Slavin G , Wills EJ , Andrews TM , Stewart G
Ref : British Medical Journal , 1 :553 , 1975
PubMedID: 1139147

Title : Ichthyosiform dermatosis with systemic lipidosis -
Author(s) : Dorfman ML , Hershko C , Eisenberg S , Sagher F
Ref : Arch Dermatol , 110 :261 , 1974
PubMedID: 4277517