Brimijoin_2008_Neuropsychopharmacology_33_2715

Reference

Title : A cocaine hydrolase engineered from human butyrylcholinesterase selectively blocks cocaine toxicity and reinstatement of drug seeking in rats - Brimijoin_2008_Neuropsychopharmacology_33_2715
Author(s) : Brimijoin S , Gao Y , Anker JJ , Gliddon LA , Lafleur D , Shah R , Zhao Q , Singh M , Carroll ME
Ref : Neuropsychopharmacology , 33 :2715 , 2008
Abstract : Successive rational mutations of human butyrylcholinesterase (BChE) followed by fusion to human serum albumin have yielded an efficient hydrolase that offers realistic options for therapy of cocaine overdose and abuse. This albumin-BChE prevented seizures in rats given a normally lethal cocaine injection (100 mg/kg, i.p.), lowered brain cocaine levels even when administered after the drug, and provided rescue after convulsions commenced. Moreover, it selectively blocked cocaine-induced reinstatement of drug seeking in rats that had previously self-administered cocaine. The enzyme treatment was well tolerated and may be worth exploring for clinical application in humans.
ESTHER : Brimijoin_2008_Neuropsychopharmacology_33_2715
PubMedSearch : Brimijoin_2008_Neuropsychopharmacology_33_2715
PubMedID: 18199998

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Citations formats

Brimijoin S, Gao Y, Anker JJ, Gliddon LA, Lafleur D, Shah R, Zhao Q, Singh M, Carroll ME (2008)
A cocaine hydrolase engineered from human butyrylcholinesterase selectively blocks cocaine toxicity and reinstatement of drug seeking in rats
Neuropsychopharmacology 33 :2715

Brimijoin S, Gao Y, Anker JJ, Gliddon LA, Lafleur D, Shah R, Zhao Q, Singh M, Carroll ME (2008)
Neuropsychopharmacology 33 :2715