Bruggmann_2003_Life.Sci_72_2095

Reference

Title : Rat arteries contain multiple nicotinic acetylcholine receptor alpha-subunits - Bruggmann_2003_Life.Sci_72_2095
Author(s) : Bruggmann D , Lips KS , Pfeil U , Haberberger RV , Kummer W
Ref : Life Sciences , 72 :2095 , 2003
Abstract :

We investigated the occurrence and distribution of the ligand-binding alpha-subunits of nicotinic acetylcholine receptors in the rat arterial system in situ by means of RT-PCR and immunohistochemistry. Except the alpha9-subunit, all other mammalian non-muscular alpha-subunits were expressed in the arterial wall--either in endothelial or in smooth muscle cells--suggesting it as a direct target of nicotine and endogenous acetylcholine. The distribution pattern of alpha-subunits found in smooth muscle cells varied considerably among the individual elastic, muscular and intraparenchymal arteries investigated, suggesting that non-neuronal cholinergic signalling via nicotinic receptors in the vascular wall includes components that are highly specific for individual arteries.

PubMedSearch : Bruggmann_2003_Life.Sci_72_2095
PubMedID: 12628463

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Citations formats

Bruggmann D, Lips KS, Pfeil U, Haberberger RV, Kummer W (2003)
Rat arteries contain multiple nicotinic acetylcholine receptor alpha-subunits
Life Sciences 72 :2095

Bruggmann D, Lips KS, Pfeil U, Haberberger RV, Kummer W (2003)
Life Sciences 72 :2095