Title : The Synthesis of Certain Derivatives and Analogues of (-)- and (+)-Galanthamine and an Assessment of their Capacities to Inhibit Acetylcholine Esterase - Buckler_2017_J.Org.Chem_82_7869 |
Author(s) : Buckler JN , Taher ES , Fraser NJ , Willis AC , Carr PD , Jackson CJ , Banwell MG |
Ref : J Org Chem , 82 :7869 , 2017 |
Abstract :
Syntheses of certain di- and mono-oxygenated derivatives (e.g., 2 and 3, respectively) and analogues (e.g., 4, a D-ring monoseco-analogue of 2) of both the (-)- and (+)-enantiomeric forms of the alkaloid galanthamine [(-)-1] are reported. All have been assessed for their capacities to inhibit acetylcholine esterase but, in contrast to the predictions from docking studies, none bind strongly to this enzyme. |
PubMedSearch : Buckler_2017_J.Org.Chem_82_7869 |
PubMedID: 28671462 |
Inhibitor | Galanthamine |
Buckler JN, Taher ES, Fraser NJ, Willis AC, Carr PD, Jackson CJ, Banwell MG (2017)
The Synthesis of Certain Derivatives and Analogues of (-)- and (+)-Galanthamine and an Assessment of their Capacities to Inhibit Acetylcholine Esterase
J Org Chem
82 :7869
Buckler JN, Taher ES, Fraser NJ, Willis AC, Carr PD, Jackson CJ, Banwell MG (2017)
J Org Chem
82 :7869