Buckler_2017_J.Org.Chem_82_7869

Reference

Title : The Synthesis of Certain Derivatives and Analogues of (-)- and (+)-Galanthamine and an Assessment of their Capacities to Inhibit Acetylcholine Esterase - Buckler_2017_J.Org.Chem_82_7869
Author(s) : Buckler JN , Taher ES , Fraser NJ , Willis AC , Carr PD , Jackson CJ , Banwell MG
Ref : J Org Chem , 82 :7869 , 2017
Abstract :

Syntheses of certain di- and mono-oxygenated derivatives (e.g., 2 and 3, respectively) and analogues (e.g., 4, a D-ring monoseco-analogue of 2) of both the (-)- and (+)-enantiomeric forms of the alkaloid galanthamine [(-)-1] are reported. All have been assessed for their capacities to inhibit acetylcholine esterase but, in contrast to the predictions from docking studies, none bind strongly to this enzyme.

PubMedSearch : Buckler_2017_J.Org.Chem_82_7869
PubMedID: 28671462

Related information

Inhibitor Galanthamine

Citations formats

Buckler JN, Taher ES, Fraser NJ, Willis AC, Carr PD, Jackson CJ, Banwell MG (2017)
The Synthesis of Certain Derivatives and Analogues of (-)- and (+)-Galanthamine and an Assessment of their Capacities to Inhibit Acetylcholine Esterase
J Org Chem 82 :7869

Buckler JN, Taher ES, Fraser NJ, Willis AC, Carr PD, Jackson CJ, Banwell MG (2017)
J Org Chem 82 :7869