| Title : Different sensitivities to agonist of muscarinic acetylcholine receptor subtypes - Bujo_1988_FEBS.Lett_240_95 |
| Author(s) : Bujo H , Nakai J , Kubo T , Fukuda K , Akiba I , Maeda A , Mishina M , Numa S |
| Ref : FEBS Letters , 240 :95 , 1988 |
|
Abstract :
Muscarinic acetylcholine receptor (mAChR) III expressed in Xenopus oocytes, like mAChR I, mediates activation of a Ca2+-dependent Cl- current, whereas mAChR IV, like mAChR II, principally induces activation of Na+ and K+ currents in a Ca2+-independent manner. mAChR III has a sensitivity to agonist of about one order of magnitude higher than that of mAChR I in mediating the Ca2+-dependent current response in Xenopus oocytes and in stimulating phosphoinositide hydrolysis in NG108-15 neuroblastoma-glioma hybrid cells. The agonist-binding affinity of mAChR III is also about one order of magnitude higher than that of mAChR I. |
| PubMedSearch : Bujo_1988_FEBS.Lett_240_95 |
| PubMedID: 3142796 |
Bujo H, Nakai J, Kubo T, Fukuda K, Akiba I, Maeda A, Mishina M, Numa S (1988)
Different sensitivities to agonist of muscarinic acetylcholine receptor subtypes
FEBS Letters
240 :95
Bujo H, Nakai J, Kubo T, Fukuda K, Akiba I, Maeda A, Mishina M, Numa S (1988)
FEBS Letters
240 :95