Numa S

General

Full name : Numa Shosaku

First name : Shosaku

Mail : Department of Medical Chemistry, Kyoto University Faculty of Medicine

Zip Code :

City :

Country : Japan

Email :

Phone :

Fax :

Website : \/\/www.sciencedirect.com\/science\/article\/pii\/S0079612308623754

Directory :

Comment
Shosaku Numa was born in 1929 and passed away on february 15 1992. Numa pioneered the use of recombinant DNA technology to reveal the molecular structure of receptors and ion channels in excitable membranes. An obituary paper by Herbert Ladinsky retraces his achievements.

References (29)

Title : Rings of anionic amino acids as structural determinants of ion selectivity in the acetylcholine receptor channel - Konno_1991_Proc.Biol.Sci_244_69
Author(s) : Konno T , Busch C , Von Kitzing E , Imoto K , Wang F , Nakai J , Mishina M , Numa S , Sakmann B
Ref : Proc Biol Sci , 244 :69 , 1991
Abstract :
PubMedSearch : Konno_1991_Proc.Biol.Sci_244_69
PubMedID: 1679551

Title : A ring of uncharged polar amino acids as a component of channel constriction in the nicotinic acetylcholine receptor - Imoto_1991_FEBS.Lett_289_193
Author(s) : Imoto K , Konno T , Nakai J , Wang F , Mishina M , Numa S
Ref : FEBS Letters , 289 :193 , 1991
Abstract :
PubMedSearch : Imoto_1991_FEBS.Lett_289_193
PubMedID: 1717313

Title : Selective coupling of different muscarinic acetylcholine receptors to neuronal calcium currents in DNA-transfected cells - Higashida_1990_Proc.Biol.Sci_242_68
Author(s) : Higashida H , Hashii M , Fukuda K , Caulfield MP , Numa S , Brown DA
Ref : Proc Biol Sci , 242 :68 , 1990
Abstract :
PubMedSearch : Higashida_1990_Proc.Biol.Sci_242_68
PubMedID: 1980742

Title : Spontaneous and agonist-induced openings of an acetylcholine receptor channel composed of bovine muscle alpha-, beta- and delta-subunits - Jackson_1990_Pflugers.Arch_417_129
Author(s) : Jackson MB , Imoto K , Mishina M , Konno T , Numa S , Sakmann B
Ref : Pflugers Arch , 417 :129 , 1990
Abstract :
PubMedSearch : Jackson_1990_Pflugers.Arch_417_129
PubMedID: 1707514

Title : Functional expression of the calcium release channel from skeletal muscle ryanodine receptor cDNA - Penner_1989_FEBS.Lett_259_217
Author(s) : Penner R , Neher E , Takeshima H , Nishimura S , Numa S
Ref : FEBS Letters , 259 :217 , 1989
Abstract :
PubMedSearch : Penner_1989_FEBS.Lett_259_217
PubMedID: 2557244

Title : Different sensitivities to agonist of muscarinic acetylcholine receptor subtypes - Bujo_1988_FEBS.Lett_240_95
Author(s) : Bujo H , Nakai J , Kubo T , Fukuda K , Akiba I , Maeda A , Mishina M , Numa S
Ref : FEBS Letters , 240 :95 , 1988
Abstract :
PubMedSearch : Bujo_1988_FEBS.Lett_240_95
PubMedID: 3142796

Title : Intracellular calcium release mediated by two muscarinic receptor subtypes - Neher_1988_FEBS.Lett_240_88
Author(s) : Neher E , Marty A , Fukuda K , Kubo T , Numa S
Ref : FEBS Letters , 240 :88 , 1988
Abstract :
PubMedSearch : Neher_1988_FEBS.Lett_240_88
PubMedID: 3192003

Title : Location of a region of the muscarinic acetylcholine receptor involved in selective effector coupling - Kubo_1988_FEBS.Lett_241_119
Author(s) : Kubo T , Bujo H , Akiba I , Nakai J , Mishina M , Numa S
Ref : FEBS Letters , 241 :119 , 1988
Abstract :
PubMedSearch : Kubo_1988_FEBS.Lett_241_119
PubMedID: 3197827

Title : Rings of negatively charged amino acids determine the acetylcholine receptor channel conductance - Imoto_1988_Nature_335_645
Author(s) : Imoto K , Busch C , Sakmann B , Mishina M , Konno T , Nakai J , Bujo H , Mori Y , Fukuda K , Numa S
Ref : Nature , 335 :645 , 1988
Abstract :
PubMedSearch : Imoto_1988_Nature_335_645
PubMedID: 2459620

Title : Tissue distribution of mRNAs encoding muscarinic acetylcholine receptor subtypes - Maeda_1988_FEBS.Lett_239_339
Author(s) : Maeda A , Kubo T , Mishina M , Numa S
Ref : FEBS Letters , 239 :339 , 1988
Abstract :
PubMedSearch : Maeda_1988_FEBS.Lett_239_339
PubMedID: 3181438

Title : Primary structure of porcine muscarinic acetylcholine receptor III and antagonist binding studies - Akiba_1988_FEBS.Lett_235_257
Author(s) : Akiba I , Kubo T , Maeda A , Bujo H , Nakai J , Mishina M , Numa S
Ref : FEBS Letters , 235 :257 , 1988
Abstract :
PubMedSearch : Akiba_1988_FEBS.Lett_235_257
PubMedID: 3402600

Title : Molecular basis of the functional heterogeneity of the muscarinic acetylcholine receptor -
Author(s) : Numa S , Fukuda K , Kubo T , Maeda A , Akiba I , Bujo H , Nakai J , Mishina M , Higashida H
Ref : Cold Spring Harbor Symposium on Quantitative Biology , 53 Pt 1 :295 , 1988
PubMedID: 3254775

Title : Effects of substitution of putative transmembrane segments on nicotinic acetylcholine receptor function - Tobimatsu_1987_FEBS.Lett_222_56
Author(s) : Tobimatsu T , Fujita Y , Fukuda K , Tanaka K , Mori Y , Konno T , Mishina M , Numa S
Ref : FEBS Letters , 222 :56 , 1987
Abstract :
PubMedSearch : Tobimatsu_1987_FEBS.Lett_222_56
PubMedID: 3653401

Title : Functional properties of nicotinic acetylcholine receptor subunits expressed in various combinations - Kurosaki_1987_FEBS.Lett_214_253
Author(s) : Kurosaki T , Fukuda K , Konno T , Mori Y , Tanaka K , Mishina M , Numa S
Ref : FEBS Letters , 214 :253 , 1987
Abstract :
PubMedSearch : Kurosaki_1987_FEBS.Lett_214_253
PubMedID: 2436944

Title : Differential regulation of muscle acetylcholine receptor gamma- and epsilon-subunit mRNAs - Witzemann_1987_FEBS.Lett_223_104
Author(s) : Witzemann V , Barg B , Nishikawa Y , Sakmann B , Numa S
Ref : FEBS Letters , 223 :104 , 1987
Abstract :
PubMedSearch : Witzemann_1987_FEBS.Lett_223_104
PubMedID: 3666131

Title : Molecular distinction between muscarinic acetylcholine receptor subtypes - Fukuda_1987_Nature_327_623
Author(s) : Fukuda K , Kubo T , Akiba I , Maeda A , Mishina M , Numa S
Ref : Nature , 327 :623 , 1987
Abstract :
PubMedSearch : Fukuda_1987_Nature_327_623
PubMedID: 3110621

Title : Location of a delta-subunit region determining ion transport through the acetylcholine receptor channel - Imoto_1986_Nature_324_670
Author(s) : Imoto K , Methfessel C , Sakmann B , Mishina M , Mori Y , Konno T , Fukuda K , Kurasaki M , Bujo H , Fujita Y , Numa S
Ref : Nature , 324 :670 , 1986
Abstract :
PubMedSearch : Imoto_1986_Nature_324_670
PubMedID: 2432430

Title : Patch clamp measurements on Xenopus laevis oocytes: currents through endogenous channels and implanted acetylcholine receptor and sodium channels - Methfessel_1986_Pflugers.Arch_407_577
Author(s) : Methfessel C , Witzemann V , Takahashi T , Mishina M , Numa S , Sakmann B
Ref : Pflugers Arch , 407 :577 , 1986
Abstract :
PubMedSearch : Methfessel_1986_Pflugers.Arch_407_577
PubMedID: 2432468

Title : Molecular basis for the function of ionic channels - Numa_1986_Biochem.Soc.Symp_52_119
Author(s) : Numa S
Ref : Biochemical Society Symposium , 52 :119 , 1986
Abstract :
PubMedSearch : Numa_1986_Biochem.Soc.Symp_52_119
PubMedID: 2437927

Title : Molecular distinction between fetal and adult forms of muscle acetylcholine receptor - Mishina_1986_Nature_321_406
Author(s) : Mishina M , Takai T , Imoto K , Noda M , Takahashi T , Numa S , Methfessel C , Sakmann B
Ref : Nature , 321 :406 , 1986
Abstract :
PubMedSearch : Mishina_1986_Nature_321_406
PubMedID: 2423878

Title : Cloning and sequence analysis of human genomic DNA encoding gamma subunit precursor of muscle acetylcholine receptor - Shibahara_1985_Eur.J.Biochem_146_15
Author(s) : Shibahara S , Kubo T , Perski HJ , Takahashi H , Noda M , Numa S
Ref : European Journal of Biochemistry , 146 :15 , 1985
Abstract :
PubMedSearch : Shibahara_1985_Eur.J.Biochem_146_15
PubMedID: 3967651

Title : A physiological study on acetylcholine receptor expressed in Xenopus oocytes from cloned cDNAs - Takahashi_1985_J.Physiol.Paris_80_229
Author(s) : Takahashi T , Kuno M , Mishina M , Numa S
Ref : Journal de Physiologie (Paris) , 80 :229 , 1985
Abstract :
PubMedSearch : Takahashi_1985_J.Physiol.Paris_80_229
PubMedID: 3834076

Title : Role of acetylcholine receptor subunits in gating of the channel - Sakmann_1985_Nature_318_538
Author(s) : Sakmann B , Methfessel C , Mishina M , Takahashi T , Takai T , Kurasaki M , Fukuda K , Numa S
Ref : Nature , 318 :538 , 1985
Abstract :
PubMedSearch : Sakmann_1985_Nature_318_538
PubMedID: 2415826

Title : Primary structure of beta subunit precursor of calf muscle acetylcholine receptor deduced from cDNA sequence - Tanabe_1984_Eur.J.Biochem_144_11
Author(s) : Tanabe T , Noda M , Furutani Y , Takai T , Takahashi H , Tanaka K , Hirose T , Inayama S , Numa S
Ref : European Journal of Biochemistry , 144 :11 , 1984
Abstract :
PubMedSearch : Tanabe_1984_Eur.J.Biochem_144_11
PubMedID: 6548186

Title : Structural homology of nicotinic acetylcholine receptor subunits -
Author(s) : Numa S
Ref : Biochemical Society Symposium , 49 :9 , 1984
PubMedID: 6571211

Title : Structural homology of Torpedo californica acetylcholine receptor subunits - Noda_1983_Nature_302_528
Author(s) : Noda M , Takahashi H , Tanabe T , Toyosato M , Kikyotani S , Furutani Y , Hirose T , Takashima H , Inayama S , Miyata T , Numa S
Ref : Nature , 302 :528 , 1983
Abstract :
PubMedSearch : Noda_1983_Nature_302_528
PubMedID: 6188060

Title : Primary structures of beta- and delta-subunit precursors of Torpedo californica acetylcholine receptor deduced from cDNA sequences - Noda_1983_Nature_301_251
Author(s) : Noda M , Takahashi H , Tanabe T , Toyosato M , Kikyotani S , Hirose T , Asai M , Takashima H , Inayama S , Miyata T , Numa S
Ref : Nature , 301 :251 , 1983
Abstract :
PubMedSearch : Noda_1983_Nature_301_251
PubMedID: 6687403

Title : Molecular structure of the nicotinic acetylcholine receptor -
Author(s) : Numa S , Noda M , Takahashi H , Tanabe T , Toyosato M , Furutani Y , Kikyotani S
Ref : Cold Spring Harbor Symposium on Quantitative Biology , 48 Pt 1 :57 , 1983
PubMedID: 6586363

Title : Primary structure of alpha-subunit precursor of Torpedo californica acetylcholine receptor deduced from cDNA sequence - Noda_1982_Nature_299_793
Author(s) : Noda M , Takahashi H , Tanabe T , Toyosato M , Furutani Y , Hirose T , Asai M , Inayama S , Miyata T , Numa S
Ref : Nature , 299 :793 , 1982
Abstract :
PubMedSearch : Noda_1982_Nature_299_793
PubMedID: 6182472