| Title : Adamantyl-ureas with pyrazoles substituted by fluoroalkanes as soluble epoxide hydrolase inhibitors - Burmistrov_2023_J.Fluor.Chem_266_ |
| Author(s) : Burmistrov VV , Morisseau C , Shkineva TK , Danilov DV , Gladkikh B , Butov GM , Fayzullin RR , Dutova TY , Hammock BD , Dalinger IL |
| Ref : J Fluor Chem , 266 : , 2023 |
|
Abstract :
A series of soluble epoxide hydrolase (sEH) inhibitors containing halogenated pyrazoles was developed. Inhibition potency of the obtained compounds ranges from 0.8 to 27.5 nM. 1-Adamantyl-3-[(4,5-dichloro-1-methyl-1-pyrazol-3-yl)methyl]urea (3f, IC(50) = 0.8 nM) and 1-[(Adamantan-1-yl)methyl]-3-[(4,5-dichloro-1-methyl-1-pyrazol-3-yl)methyl]urea (4f, IC(50) = 1.2 nM) were found to be the most potent sEH inhibitors within the described series. |
| PubMedSearch : Burmistrov_2023_J.Fluor.Chem_266_ |
| PubMedID: 37638129 |
Burmistrov VV, Morisseau C, Shkineva TK, Danilov DV, Gladkikh B, Butov GM, Fayzullin RR, Dutova TY, Hammock BD, Dalinger IL (2023)
Adamantyl-ureas with pyrazoles substituted by fluoroalkanes as soluble epoxide hydrolase inhibitors
J Fluor Chem
266 :
Burmistrov VV, Morisseau C, Shkineva TK, Danilov DV, Gladkikh B, Butov GM, Fayzullin RR, Dutova TY, Hammock BD, Dalinger IL (2023)
J Fluor Chem
266 :